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KEY FACTS
Terminology
Imaging
Top Differential Diagnoses
Clinical Issues
Diagnostic Checklist
TERMINOLOGY
Synonyms
Bile duct cystadenocarcinoma, hepatobiliary cystadenoma
Definitions
Rare, malignant or premalignant, unilocular or multilocular, cystic tumor
May arise from intrahepatic bile ducts (IHBDs) within liver (common site)
Uncommonly from extrahepatic biliary tree or gallbladder
IMAGING
General Features
CT Findings
MR Findings
Ultrasonographic Findings
Angiographic Findings
Imaging Recommendations
DIFFERENTIAL DIAGNOSIS
PATHOLOGY
General Features
Gross Pathologic & Surgical Features
Microscopic Features
CLINICAL ISSUES
Presentation
Demographics
Natural History & Prognosis
Treatment
DIAGNOSTIC CHECKLIST
Consider
Image Interpretation Pearls
Selected References
Nagtegaal ID et al: The 2019 WHO classification of tumours of the digestive system. Histopathology. 76(2):182-8, 2020
Averbukh LD et al: Biliary mucinous cystadenoma: a review of the literature. J Clin Transl Hepatol. 7(2):149-53, 2019
Mavilia MG et al: Differentiating cystic liver lesions: a review of imaging modalities, diagnosis and management. J Clin Transl Hepatol. 6(2):208-16, 2018
Park HJ et al: Intraductal papillary neoplasm of the bile duct: clinical, imaging, and pathologic features. AJR Am J Roentgenol. 211(1):67-75, 2018
Dong Y et al: Contrast enhanced ultrasound features of hepatic cystadenoma and hepatic cystadenocarcinoma. Scand J Gastroenterol. 52(3):365-72, 2017
Pitchaimuthu M et al: Cystic lesions of the liver-a review. Curr Probl Surg. 54(10):514-42, 2017
Arnaoutakis DJ et al: Management of biliary cystic tumors: a multi-institutional analysis of a rare liver tumor. Ann Surg. 261(2):361-7, 2014
Chen YW et al: Surgical management of biliary cystadenoma and cystadenocarcinoma of the liver. Genet Mol Res. 13(3):6383-90, 2014
Cogley JR et al: MR imaging of benign focal liver lesions. Radiol Clin North Am. 52(4):657-82, 2014
Soares KC et al: Cystic neoplasms of the liver: biliary cystadenoma and cystadenocarcinoma. J Am Coll Surg. 218(1):119-28, 2014
Doepker M et al: Biliary cystadenoma: case series and review of the literature. Am Surg. 77(4):505-6, 2011
Romagnoli R et al: Liver transplantation for symptomatic centrohepatic biliary cystadenoma. Clin Res Hepatol Gastroenterol. 35(5):408-13, 2011
Sang X et al: Hepatobiliary cystadenomas and cystadenocarcinomas: a report of 33 cases. Liver Int. 31(9):1337-44, 2011
Bogert JN et al: Education and imaging. Hepatobiliary and pancreatic: mucinous cystadenoma of the biliary tree. J Gastroenterol Hepatol. 25(7):1332, 2010
Choi HK et al: Differential diagnosis for intrahepatic biliary cystadenoma and hepatic simple cyst: significance of cystic fluid analysis and radiologic findings. J Clin Gastroenterol. 44(4):289-93, 2010
Seo JK et al: Appropriate diagnosis of biliary cystic tumors: comparison with atypical hepatic simple cysts. Eur J Gastroenterol Hepatol. 22(8):989-96, 2010
Yu J et al: Hepatobiliary mucinous cystadenoma and cystadenocarcinoma: report of six cases and review of the literature. Hepatogastroenterology. 57(99-100):451-5, 2010
Limongelli P et al: Cystic tumors of the biliary tract: a complete excision is crucial. Int Surg. 94(2):136-40, 2009
Del Poggio P et al: Cystic tumors of the liver: a practical approach. World J Gastroenterol. 14(23):3616-20, 2008
Delis SG et al: Intrahepatic biliary cystadenoma: a need for radical resection. Eur J Gastroenterol Hepatol. 20(1):10-4, 2008
Mourra N et al: Clinical challenges and images in GI. Extrahepatic biliary cystadenoma with mesenchymal stroma. Gastroenterology. 134(5):1295, 1637, 2008
Levy AD et al: From the archives of the AFIP. Benign tumors and tumorlike lesions of the gallbladder and extrahepatic bile ducts: radiologic-pathologic correlation. Armed Forces Institute of Pathology. Radiographics. 22(2):387-413, 2002
Gabata T et al: Biliary cystadenoma with mesenchymal stroma of the liver: correlation between unusual MR appearance and pathologic findings. J Magn Reson Imaging. 8(2):503-4, 1998
Singh Y et al: Multiloculated cystic liver lesions: radiologic-pathologic differential diagnosis. Radiographics. 17(1):219-24, 1997
Buetow PC et al: Biliary cystadenoma and cystadenocarcinoma: clinical-imaging-pathologic correlations with emphasis on the importance of ovarian stroma. Radiology. 196(3):805-10, 1995
Related Anatomy
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Related Differential Diagnoses
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References
Tables
Tables
KEY FACTS
Terminology
Imaging
Top Differential Diagnoses
Clinical Issues
Diagnostic Checklist
TERMINOLOGY
Synonyms
Bile duct cystadenocarcinoma, hepatobiliary cystadenoma
Definitions
Rare, malignant or premalignant, unilocular or multilocular, cystic tumor
May arise from intrahepatic bile ducts (IHBDs) within liver (common site)
Uncommonly from extrahepatic biliary tree or gallbladder
IMAGING
General Features
CT Findings
MR Findings
Ultrasonographic Findings
Angiographic Findings
Imaging Recommendations
DIFFERENTIAL DIAGNOSIS
PATHOLOGY
General Features
Gross Pathologic & Surgical Features
Microscopic Features
CLINICAL ISSUES
Presentation
Demographics
Natural History & Prognosis
Treatment
DIAGNOSTIC CHECKLIST
Consider
Image Interpretation Pearls
Selected References
Nagtegaal ID et al: The 2019 WHO classification of tumours of the digestive system. Histopathology. 76(2):182-8, 2020
Averbukh LD et al: Biliary mucinous cystadenoma: a review of the literature. J Clin Transl Hepatol. 7(2):149-53, 2019
Mavilia MG et al: Differentiating cystic liver lesions: a review of imaging modalities, diagnosis and management. J Clin Transl Hepatol. 6(2):208-16, 2018
Park HJ et al: Intraductal papillary neoplasm of the bile duct: clinical, imaging, and pathologic features. AJR Am J Roentgenol. 211(1):67-75, 2018
Dong Y et al: Contrast enhanced ultrasound features of hepatic cystadenoma and hepatic cystadenocarcinoma. Scand J Gastroenterol. 52(3):365-72, 2017
Pitchaimuthu M et al: Cystic lesions of the liver-a review. Curr Probl Surg. 54(10):514-42, 2017
Arnaoutakis DJ et al: Management of biliary cystic tumors: a multi-institutional analysis of a rare liver tumor. Ann Surg. 261(2):361-7, 2014
Chen YW et al: Surgical management of biliary cystadenoma and cystadenocarcinoma of the liver. Genet Mol Res. 13(3):6383-90, 2014
Cogley JR et al: MR imaging of benign focal liver lesions. Radiol Clin North Am. 52(4):657-82, 2014
Soares KC et al: Cystic neoplasms of the liver: biliary cystadenoma and cystadenocarcinoma. J Am Coll Surg. 218(1):119-28, 2014
Doepker M et al: Biliary cystadenoma: case series and review of the literature. Am Surg. 77(4):505-6, 2011
Romagnoli R et al: Liver transplantation for symptomatic centrohepatic biliary cystadenoma. Clin Res Hepatol Gastroenterol. 35(5):408-13, 2011
Sang X et al: Hepatobiliary cystadenomas and cystadenocarcinomas: a report of 33 cases. Liver Int. 31(9):1337-44, 2011
Bogert JN et al: Education and imaging. Hepatobiliary and pancreatic: mucinous cystadenoma of the biliary tree. J Gastroenterol Hepatol. 25(7):1332, 2010
Choi HK et al: Differential diagnosis for intrahepatic biliary cystadenoma and hepatic simple cyst: significance of cystic fluid analysis and radiologic findings. J Clin Gastroenterol. 44(4):289-93, 2010
Seo JK et al: Appropriate diagnosis of biliary cystic tumors: comparison with atypical hepatic simple cysts. Eur J Gastroenterol Hepatol. 22(8):989-96, 2010
Yu J et al: Hepatobiliary mucinous cystadenoma and cystadenocarcinoma: report of six cases and review of the literature. Hepatogastroenterology. 57(99-100):451-5, 2010
Limongelli P et al: Cystic tumors of the biliary tract: a complete excision is crucial. Int Surg. 94(2):136-40, 2009
Del Poggio P et al: Cystic tumors of the liver: a practical approach. World J Gastroenterol. 14(23):3616-20, 2008
Delis SG et al: Intrahepatic biliary cystadenoma: a need for radical resection. Eur J Gastroenterol Hepatol. 20(1):10-4, 2008
Mourra N et al: Clinical challenges and images in GI. Extrahepatic biliary cystadenoma with mesenchymal stroma. Gastroenterology. 134(5):1295, 1637, 2008
Levy AD et al: From the archives of the AFIP. Benign tumors and tumorlike lesions of the gallbladder and extrahepatic bile ducts: radiologic-pathologic correlation. Armed Forces Institute of Pathology. Radiographics. 22(2):387-413, 2002
Gabata T et al: Biliary cystadenoma with mesenchymal stroma of the liver: correlation between unusual MR appearance and pathologic findings. J Magn Reson Imaging. 8(2):503-4, 1998
Singh Y et al: Multiloculated cystic liver lesions: radiologic-pathologic differential diagnosis. Radiographics. 17(1):219-24, 1997
Buetow PC et al: Biliary cystadenoma and cystadenocarcinoma: clinical-imaging-pathologic correlations with emphasis on the importance of ovarian stroma. Radiology. 196(3):805-10, 1995
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