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Biliary Hamartoma
Michael P. Federle, MD, FACR
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KEY FACTS

  • Terminology

    • Imaging

      • Top Differential Diagnoses

        • Diagnostic Checklist

          TERMINOLOGY

          • Synonyms

            • Bile duct microhamartoma
            • von Meyenburg complex
          • Definitions

            • Uncommon benign malformations of biliary tract

          IMAGING

          • General Features

            • CT Findings

              • MR Findings

                • Ultrasonographic Findings

                  • Angiographic Findings

                    • Imaging Recommendations

                      DIFFERENTIAL DIAGNOSIS

                        PATHOLOGY

                        • General Features

                          • Staging, Grading, & Classification

                            • Gross Pathologic & Surgical Features

                              • Microscopic Features

                                CLINICAL ISSUES

                                • Presentation

                                  • Demographics

                                    • Natural History & Prognosis

                                      • Treatment

                                        DIAGNOSTIC CHECKLIST

                                        • Consider

                                          • Image Interpretation Pearls

                                            Selected References

                                            1. Lin S et al: A study of multiple biliary hamartomas based on 1697 liver biopsies. Eur J Gastroenterol Hepatol. 25(8):948-52, 2013
                                            2. Gil-Bello D et al: Calcification in biliary hamartomatosis. Br J Radiol. 85(1012):e99-101, 2012
                                            3. Desmet VJ: Ductal plates in hepatic ductular reactions. Hypothesis and implications. III. Implications for liver pathology. Virchows Arch. 458(3):271-9, 2011
                                            4. Venkatanarasimha N et al: Imaging features of ductal plate malformations in adults. Clin Radiol. 66(11):1086-93, 2011
                                            5. Drenth JP et al: Congenital fibrocystic liver diseases. Best Pract Res Clin Gastroenterol. 24(5):573-84, 2010
                                            6. Hughes NR et al: An immunohistochemical profile of the so-called bile duct adenoma: clues to pathogenesis. Am J Surg Pathol. 34(9):1312-8, 2010
                                            7. Tohmé-Noun C et al: Multiple biliary hamartomas: magnetic resonance features with histopathologic correlation. Eur Radiol. 18(3):493-9, 2008
                                            8. Orii T et al: Cholangiocarcinoma arising from preexisting biliary hamartoma of liver--report of a case. Hepatogastroenterology. 50(50):333-6, 2003
                                            9. Mortele B et al: Hepatic bile duct hamartomas (von Meyenburg Complexes): MR and MR cholangiography findings. J Comput Assist Tomogr. 26(3):438-43, 2002
                                            10. Allgaier HP et al: Ampullary hamartoma: A rare cause of biliary obstruction. Digestion. 60(5):497-500, 1999
                                            11. Semelka RC et al: Biliary hamartomas: solitary and multiple lesions shown on current MR techniques including gadolinium enhancement. J Magn Reson Imaging. 10(2):196-201, 1999
                                            12. von Schweinitz D et al: Mesenchymal hamartoma of the liver--new insight into histogenesis. J Pediatr Surg. 34(8):1269-71, 1999
                                            13. Cheung YC et al: MRI of multiple biliary hamartomas. Br J Radiol. 70(833):527-9, 1997
                                            14. Principe A et al: Bile duct hamartomas: diagnostic problems and treatment. Hepatogastroenterology. 44(16):994-7, 1997
                                            15. Iha H et al: Biliary hamartomas simulating multiple hepatic metastasis on imaging findings. Kurume Med J. 43(3):231-5, 1996
                                            16. Lev-Toaff AS et al: The radiologic and pathologic spectrum of biliary hamartomas. AJR Am J Roentgenol. 165(2):309-13, 1995
                                            Related Anatomy
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                                            Related Differential Diagnoses
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                                            References
                                            Tables

                                            Tables

                                            KEY FACTS

                                            • Terminology

                                              • Imaging

                                                • Top Differential Diagnoses

                                                  • Diagnostic Checklist

                                                    TERMINOLOGY

                                                    • Synonyms

                                                      • Bile duct microhamartoma
                                                      • von Meyenburg complex
                                                    • Definitions

                                                      • Uncommon benign malformations of biliary tract

                                                    IMAGING

                                                    • General Features

                                                      • CT Findings

                                                        • MR Findings

                                                          • Ultrasonographic Findings

                                                            • Angiographic Findings

                                                              • Imaging Recommendations

                                                                DIFFERENTIAL DIAGNOSIS

                                                                  PATHOLOGY

                                                                  • General Features

                                                                    • Staging, Grading, & Classification

                                                                      • Gross Pathologic & Surgical Features

                                                                        • Microscopic Features

                                                                          CLINICAL ISSUES

                                                                          • Presentation

                                                                            • Demographics

                                                                              • Natural History & Prognosis

                                                                                • Treatment

                                                                                  DIAGNOSTIC CHECKLIST

                                                                                  • Consider

                                                                                    • Image Interpretation Pearls

                                                                                      Selected References

                                                                                      1. Lin S et al: A study of multiple biliary hamartomas based on 1697 liver biopsies. Eur J Gastroenterol Hepatol. 25(8):948-52, 2013
                                                                                      2. Gil-Bello D et al: Calcification in biliary hamartomatosis. Br J Radiol. 85(1012):e99-101, 2012
                                                                                      3. Desmet VJ: Ductal plates in hepatic ductular reactions. Hypothesis and implications. III. Implications for liver pathology. Virchows Arch. 458(3):271-9, 2011
                                                                                      4. Venkatanarasimha N et al: Imaging features of ductal plate malformations in adults. Clin Radiol. 66(11):1086-93, 2011
                                                                                      5. Drenth JP et al: Congenital fibrocystic liver diseases. Best Pract Res Clin Gastroenterol. 24(5):573-84, 2010
                                                                                      6. Hughes NR et al: An immunohistochemical profile of the so-called bile duct adenoma: clues to pathogenesis. Am J Surg Pathol. 34(9):1312-8, 2010
                                                                                      7. Tohmé-Noun C et al: Multiple biliary hamartomas: magnetic resonance features with histopathologic correlation. Eur Radiol. 18(3):493-9, 2008
                                                                                      8. Orii T et al: Cholangiocarcinoma arising from preexisting biliary hamartoma of liver--report of a case. Hepatogastroenterology. 50(50):333-6, 2003
                                                                                      9. Mortele B et al: Hepatic bile duct hamartomas (von Meyenburg Complexes): MR and MR cholangiography findings. J Comput Assist Tomogr. 26(3):438-43, 2002
                                                                                      10. Allgaier HP et al: Ampullary hamartoma: A rare cause of biliary obstruction. Digestion. 60(5):497-500, 1999
                                                                                      11. Semelka RC et al: Biliary hamartomas: solitary and multiple lesions shown on current MR techniques including gadolinium enhancement. J Magn Reson Imaging. 10(2):196-201, 1999
                                                                                      12. von Schweinitz D et al: Mesenchymal hamartoma of the liver--new insight into histogenesis. J Pediatr Surg. 34(8):1269-71, 1999
                                                                                      13. Cheung YC et al: MRI of multiple biliary hamartomas. Br J Radiol. 70(833):527-9, 1997
                                                                                      14. Principe A et al: Bile duct hamartomas: diagnostic problems and treatment. Hepatogastroenterology. 44(16):994-7, 1997
                                                                                      15. Iha H et al: Biliary hamartomas simulating multiple hepatic metastasis on imaging findings. Kurume Med J. 43(3):231-5, 1996
                                                                                      16. Lev-Toaff AS et al: The radiologic and pathologic spectrum of biliary hamartomas. AJR Am J Roentgenol. 165(2):309-13, 1995