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KEY FACTS
Terminology
Imaging
Pathology
Clinical Issues
TERMINOLOGY
Abbreviations
Intraductal papillary mucinous neoplasm (IPMN)
Synonyms
Intraductal papillary neoplasm of liver, intraductal papillary neoplasm of bile duct (IPNB), mucin-secreting biliary papillomatosis, mucin-producing cholangiocarcinoma, mucinous ductal ectasia of biliary tree
Definitions
Mucin-producing papillary neoplasm arising from biliary mucosa
Only added to WHO classification in 2010
Significant overlap with biliary papillomatosis; some authors suggest these are same entity
IMAGING
General Features
Radiographic Findings
CT Findings
MR Findings
Ultrasonographic Findings
Nuclear Medicine Findings
Imaging Recommendations
DIFFERENTIAL DIAGNOSIS
PATHOLOGY
General Features
Staging, Grading, & Classification
Gross Pathologic & Surgical Features
Microscopic Features
CLINICAL ISSUES
Presentation
Demographics
Natural History & Prognosis
Treatment
DIAGNOSTIC CHECKLIST
Consider
Image Interpretation Pearls
Selected References
Aslam A et al: Intraductal papillary neoplasm of the bile duct (IPNB): CT and MRI appearance with radiology-pathology correlation. Clin Imaging. 66:10-17, 2020
Li J et al: Magnetic resonance imaging versus computed tomography for biliary tract intraductal papillary mucinous neoplasm (BT-IPMN): a diagnostic performance analysis. Med Sci Monit. 26:e920952, 2020
Raphael KL et al: Digital cholangioscopy in a patient with biliary tract intraductal papillary mucinous neoplasm. VideoGIE. 4(11):517-8, 2019
Park HJ et al: Intraductal papillary neoplasm of the bile duct: clinical, imaging, and pathologic features. AJR Am J Roentgenol. 211(1):67-75, 2018
Bal MM et al: Intraductal papillary neoplasm of the bile duct: a rarity. Indian J Pathol Microbiol. 57(1):144-5, 2014
Ohtsuka M et al: Intraductal papillary neoplasms of the bile duct. Int J Hepatol. 2014:459091, 2014
Wan XS et al: Intraductal papillary neoplasm of the bile duct. World J Gastroenterol. 19(46):8595-604, 2013
Jung G et al: Long-term clinical outcome of the surgically resected intraductal papillary neoplasm of the bile duct. J Hepatol. 57(4):787-93, 2012
Rocha FG et al: Intraductal papillary neoplasm of the bile duct: A biliary equivalent to intraductal papillary mucinous neoplasm of the pancreas? Hepatology. 56(4):1352-60, 2012
Lim JH et al: Cyst-forming intraductal papillary neoplasm of the bile ducts: description of imaging and pathologic aspects. AJR Am J Roentgenol. 197(5):1111-20, 2011
Takanami K et al: Intraductal papillary mucininous neoplasm of the bile ducts: multimodality assessment with pathologic correlation. Abdom Imaging. 36(4):447-56, 2011
Takanami K et al: FDG PET/CT findings in malignant intraductal papillary mucinous neoplasm of the bile ducts. Clin Nucl Med. 35(2):83-5, 2010
Bickenbach K et al: Molecular mechanisms of cholangiocarcinogenesis: are biliary intraepithelial neoplasia and intraductal papillary neoplasms of the bile duct precursors to cholangiocarcinoma? Surg Oncol Clin N Am. 18(2):215-24, vii, 2009
Lim JH et al: Biliary intraductal papillary-mucinous neoplasm manifesting only as dilatation of the hepatic lobar or segmental bile ducts: imaging features in six patients. AJR Am J Roentgenol. 191(3):778-82, 2008
Lim JH et al: Biliary cystic intraductal papillary mucinous tumor and cystadenoma/cystadenocarcinoma: differentiation by CT. Abdom Imaging. 32(5):644-51, 2007
Zen Y et al: Biliary papillary tumors share pathological features with intraductal papillary mucinous neoplasm of the pancreas. Hepatology. 44(5):1333-43, 2006
Lim JH et al: Intraductal papillary mucinous tumor of the bile ducts. Radiographics. 24(1):53-66; discussion 66-7, 2004
Sugiyama M et al: Magnetic resonance cholangiopancreatography for postoperative follow-up of intraductal papillary-mucinous tumors of the pancreas. Am J Surg. 185(3):251-5, 2003
Oshikiri T et al: Mucin-secreting bile duct adenoma--clinicopathological resemblance to intraductal papillary mucinous tumor of the pancreas. Dig Surg. 19(4):324-7, 2002
Related Anatomy
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Related Differential Diagnoses
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References
Tables
Tables
KEY FACTS
Terminology
Imaging
Pathology
Clinical Issues
TERMINOLOGY
Abbreviations
Intraductal papillary mucinous neoplasm (IPMN)
Synonyms
Intraductal papillary neoplasm of liver, intraductal papillary neoplasm of bile duct (IPNB), mucin-secreting biliary papillomatosis, mucin-producing cholangiocarcinoma, mucinous ductal ectasia of biliary tree
Definitions
Mucin-producing papillary neoplasm arising from biliary mucosa
Only added to WHO classification in 2010
Significant overlap with biliary papillomatosis; some authors suggest these are same entity
IMAGING
General Features
Radiographic Findings
CT Findings
MR Findings
Ultrasonographic Findings
Nuclear Medicine Findings
Imaging Recommendations
DIFFERENTIAL DIAGNOSIS
PATHOLOGY
General Features
Staging, Grading, & Classification
Gross Pathologic & Surgical Features
Microscopic Features
CLINICAL ISSUES
Presentation
Demographics
Natural History & Prognosis
Treatment
DIAGNOSTIC CHECKLIST
Consider
Image Interpretation Pearls
Selected References
Aslam A et al: Intraductal papillary neoplasm of the bile duct (IPNB): CT and MRI appearance with radiology-pathology correlation. Clin Imaging. 66:10-17, 2020
Li J et al: Magnetic resonance imaging versus computed tomography for biliary tract intraductal papillary mucinous neoplasm (BT-IPMN): a diagnostic performance analysis. Med Sci Monit. 26:e920952, 2020
Raphael KL et al: Digital cholangioscopy in a patient with biliary tract intraductal papillary mucinous neoplasm. VideoGIE. 4(11):517-8, 2019
Park HJ et al: Intraductal papillary neoplasm of the bile duct: clinical, imaging, and pathologic features. AJR Am J Roentgenol. 211(1):67-75, 2018
Bal MM et al: Intraductal papillary neoplasm of the bile duct: a rarity. Indian J Pathol Microbiol. 57(1):144-5, 2014
Ohtsuka M et al: Intraductal papillary neoplasms of the bile duct. Int J Hepatol. 2014:459091, 2014
Wan XS et al: Intraductal papillary neoplasm of the bile duct. World J Gastroenterol. 19(46):8595-604, 2013
Jung G et al: Long-term clinical outcome of the surgically resected intraductal papillary neoplasm of the bile duct. J Hepatol. 57(4):787-93, 2012
Rocha FG et al: Intraductal papillary neoplasm of the bile duct: A biliary equivalent to intraductal papillary mucinous neoplasm of the pancreas? Hepatology. 56(4):1352-60, 2012
Lim JH et al: Cyst-forming intraductal papillary neoplasm of the bile ducts: description of imaging and pathologic aspects. AJR Am J Roentgenol. 197(5):1111-20, 2011
Takanami K et al: Intraductal papillary mucininous neoplasm of the bile ducts: multimodality assessment with pathologic correlation. Abdom Imaging. 36(4):447-56, 2011
Takanami K et al: FDG PET/CT findings in malignant intraductal papillary mucinous neoplasm of the bile ducts. Clin Nucl Med. 35(2):83-5, 2010
Bickenbach K et al: Molecular mechanisms of cholangiocarcinogenesis: are biliary intraepithelial neoplasia and intraductal papillary neoplasms of the bile duct precursors to cholangiocarcinoma? Surg Oncol Clin N Am. 18(2):215-24, vii, 2009
Lim JH et al: Biliary intraductal papillary-mucinous neoplasm manifesting only as dilatation of the hepatic lobar or segmental bile ducts: imaging features in six patients. AJR Am J Roentgenol. 191(3):778-82, 2008
Lim JH et al: Biliary cystic intraductal papillary mucinous tumor and cystadenoma/cystadenocarcinoma: differentiation by CT. Abdom Imaging. 32(5):644-51, 2007
Zen Y et al: Biliary papillary tumors share pathological features with intraductal papillary mucinous neoplasm of the pancreas. Hepatology. 44(5):1333-43, 2006
Lim JH et al: Intraductal papillary mucinous tumor of the bile ducts. Radiographics. 24(1):53-66; discussion 66-7, 2004
Sugiyama M et al: Magnetic resonance cholangiopancreatography for postoperative follow-up of intraductal papillary-mucinous tumors of the pancreas. Am J Surg. 185(3):251-5, 2003
Oshikiri T et al: Mucin-secreting bile duct adenoma--clinicopathological resemblance to intraductal papillary mucinous tumor of the pancreas. Dig Surg. 19(4):324-7, 2002
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