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Bisphosphonates
Nathan D. Cecava, MD; Cheryl A. Petersilge, MD, MBA; B. J. Manaster, MD, PhD, FACR
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KEY FACTS

  • Imaging

    • Pathology

      • Clinical Issues

        Selected References

        1. Palmer W et al: Glossary of terms for musculoskeletal radiology. Skeletal Radiol. 49(Suppl 1):1-33, 2020
        2. Larsen MS et al: The enigma of atypical femoral fractures: a summary of current knowledge. EFORT Open Rev. 3(9):494-500, 2018
        3. Mallya SM et al: Imaging of radiation- and medication-related osteonecrosis. Radiol Clin North Am. 56(1):77-89, 2018
        4. Marshall RA et al: Imaging features and management of stress, atypical, and pathologic fractures. Radiographics. 38(7):2173-92, 2018
        5. Probyn L et al: Bilateral atypical femoral fractures: how much symmetry is there on imaging? Skeletal Radiol. 44(11):1579-84, 2015
        6. Dell RM et al: Incidence of atypical nontraumatic diaphyseal fractures of the femur. J Bone Miner Res. 27(12):2544-50, 2012
        7. Png MA et al: Bisphosphonate-related femoral periosteal stress reactions: scoring system based on radiographic and MRI findings. AJR Am J Roentgenol. 198(4):869-77, 2012
        8. Sidhu HS et al: Imaging features of therapeutic drug-induced musculoskeletal abnormalities. Radiographics. 32(1):105-27, 2012
        9. Vigorita VJ et al: Osteoclast abnormalities in fractured bone during bisphosphonate treatment for osteoporosis: a case report. Skeletal Radiol. 41(7):861-5, 2012
        10. Reid IR: Bisphosphonates in the treatment of osteoporosis: a review of their contribution and controversies. Skeletal Radiol. 40(9):1191-6, 2011
        11. Rosenberg ZS et al: Bisphosphonate-related complete atypical subtrochanteric femoral fractures: diagnostic utility of radiography. AJR Am J Roentgenol. 197(4):954-60, 2011
        12. Rogers LF et al: FDA statement on relationship between bisphosphonate use and atypical subtrochanteric and femoral shaft fractures: a considered opinion. AJR Am J Roentgenol. 195(3):563-6, 2010
        13. Gupta S et al: Zoledronic acid induced osteonecrosis of tibia and femur. Indian J Cancer. 46(3):249-50, 2009
        14. Morag Y et al: Bisphosphonate-related osteonecrosis of the jaw: a pictorial review. Radiographics. 29(7):1971-84, 2009
        15. Papapetrou PD: Bisphosphonate-associated adverse events. Hormones (Athens). 8(2):96-110, 2009
        16. Schilcher J et al: Incidence of stress fractures of the femoral shaft in women treated with bisphosphonate. Acta Orthop. 80(4):413-5, 2009
        17. Carey JJ et al: Bisphosphonates and osteonecrosis of the jaw: innocent association or significant risk? Cleve Clin J Med. 75(12):871-9, 2008
        18. Kwek EB et al: An emerging pattern of subtrochanteric stress fractures: a long-term complication of alendronate therapy? Injury. 39(2):224-31, 2008
        19. Lenart BA et al: Atypical fractures of the femoral diaphysis in postmenopausal women taking alendronate. N Engl J Med. 358(12):1304-6, 2008
        20. Neviaser AS et al: Low-energy femoral shaft fractures associated with alendronate use. J Orthop Trauma. 22(5):346-50, 2008
        Related Anatomy
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        References
        Tables

        Tables

        KEY FACTS

        • Imaging

          • Pathology

            • Clinical Issues

              Selected References

              1. Palmer W et al: Glossary of terms for musculoskeletal radiology. Skeletal Radiol. 49(Suppl 1):1-33, 2020
              2. Larsen MS et al: The enigma of atypical femoral fractures: a summary of current knowledge. EFORT Open Rev. 3(9):494-500, 2018
              3. Mallya SM et al: Imaging of radiation- and medication-related osteonecrosis. Radiol Clin North Am. 56(1):77-89, 2018
              4. Marshall RA et al: Imaging features and management of stress, atypical, and pathologic fractures. Radiographics. 38(7):2173-92, 2018
              5. Probyn L et al: Bilateral atypical femoral fractures: how much symmetry is there on imaging? Skeletal Radiol. 44(11):1579-84, 2015
              6. Dell RM et al: Incidence of atypical nontraumatic diaphyseal fractures of the femur. J Bone Miner Res. 27(12):2544-50, 2012
              7. Png MA et al: Bisphosphonate-related femoral periosteal stress reactions: scoring system based on radiographic and MRI findings. AJR Am J Roentgenol. 198(4):869-77, 2012
              8. Sidhu HS et al: Imaging features of therapeutic drug-induced musculoskeletal abnormalities. Radiographics. 32(1):105-27, 2012
              9. Vigorita VJ et al: Osteoclast abnormalities in fractured bone during bisphosphonate treatment for osteoporosis: a case report. Skeletal Radiol. 41(7):861-5, 2012
              10. Reid IR: Bisphosphonates in the treatment of osteoporosis: a review of their contribution and controversies. Skeletal Radiol. 40(9):1191-6, 2011
              11. Rosenberg ZS et al: Bisphosphonate-related complete atypical subtrochanteric femoral fractures: diagnostic utility of radiography. AJR Am J Roentgenol. 197(4):954-60, 2011
              12. Rogers LF et al: FDA statement on relationship between bisphosphonate use and atypical subtrochanteric and femoral shaft fractures: a considered opinion. AJR Am J Roentgenol. 195(3):563-6, 2010
              13. Gupta S et al: Zoledronic acid induced osteonecrosis of tibia and femur. Indian J Cancer. 46(3):249-50, 2009
              14. Morag Y et al: Bisphosphonate-related osteonecrosis of the jaw: a pictorial review. Radiographics. 29(7):1971-84, 2009
              15. Papapetrou PD: Bisphosphonate-associated adverse events. Hormones (Athens). 8(2):96-110, 2009
              16. Schilcher J et al: Incidence of stress fractures of the femoral shaft in women treated with bisphosphonate. Acta Orthop. 80(4):413-5, 2009
              17. Carey JJ et al: Bisphosphonates and osteonecrosis of the jaw: innocent association or significant risk? Cleve Clin J Med. 75(12):871-9, 2008
              18. Kwek EB et al: An emerging pattern of subtrochanteric stress fractures: a long-term complication of alendronate therapy? Injury. 39(2):224-31, 2008
              19. Lenart BA et al: Atypical fractures of the femoral diaphysis in postmenopausal women taking alendronate. N Engl J Med. 358(12):1304-6, 2008
              20. Neviaser AS et al: Low-energy femoral shaft fractures associated with alendronate use. J Orthop Trauma. 22(5):346-50, 2008