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Blastic Osseous Metastases
Jeffrey S. Ross, MD
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KEY FACTS

  • Terminology

    • Imaging

      • Top Differential Diagnoses

        • Pathology

          • Clinical Issues

            TERMINOLOGY

            • Synonyms

              • Sclerotic metastases, osteosclerotic metastases, osteoblastic metastases
            • Definitions

              • Spread of primary tumor to spine where bone production exceeds bone destruction

            IMAGING

            • General Features

              • Radiographic Findings

                • CT Findings

                  • MR Findings

                    • Nuclear Medicine Findings

                      • Imaging Recommendations

                        DIFFERENTIAL DIAGNOSIS

                          PATHOLOGY

                          • General Features

                            • Staging, Grading, & Classification

                              • Gross Pathologic & Surgical Features

                                • Microscopic Features

                                  CLINICAL ISSUES

                                  • Presentation

                                    • Demographics

                                      • Natural History & Prognosis

                                        • Treatment

                                          DIAGNOSTIC CHECKLIST

                                          • Consider

                                            • Image Interpretation Pearls

                                              Selected References

                                              1. Dushyanthen S et al: The osteoblastic and osteoclastic interactions in spinal metastases secondary to prostate cancer. Cancer Growth Metastasis. 6:61-80, 2013
                                              2. Goudarzi B et al: Detection of bone metastases using diffusion weighted magnetic resonance imaging: comparison with (11)C-methionine PET and bone scintigraphy. Magn Reson Imaging. 28(3):372-379, 2010
                                              3. Borad MJ et al: Skeletal metastases in pancreatic cancer: a retrospective study and review of the literature. Yale J Biol Med. 82(1):1-6, 2009
                                              4. Oztekin O et al: SSH-EPI diffusion-weighted MR imaging of the spine with low b values: is it useful in differentiating malignant metastatic tumor infiltration from benign fracture edema? Skeletal Radiol. 38(7):651-8, 2009
                                              5. Israel O et al: FDG-PET and CT patterns of bone metastases and their relationship to previously administered anti-cancer therapy. Eur J Nucl Med Mol Imaging. 33(11):1280-4, 2006
                                              6. Fogelman I et al: Positron emission tomography and bone metastases. Semin Nucl Med. 35(2):135-42, 2005
                                              7. Nakai T et al: Pitfalls of FDG-PET for the diagnosis of osteoblastic bone metastases in patients with breast cancer. Eur J Nucl Med Mol Imaging. 32(11):1253-8, 2005
                                              8. Tomita K et al: Surgical strategy for spinal metastases. Spine. 26(3):298-306, 2001
                                              9. Wahl RL: Current status of PET in breast cancer imaging, staging, and therapy. Semin Roentgenol. 36(3):250-60, 2001
                                              10. Castillo M et al: Diffusion-weighted MR imaging offers no advantage over routine noncontrast MR imaging in the detection of vertebral metastases. AJNR Am J Neuroradiol. 21(5):948-53, 2000
                                              11. Chamberlain MC et al: Epidural spinal cord compression: a single institution's retrospective experience. Neuro Oncol. 1(2):120-3, 1999
                                              12. Vanel D et al: MRI of bone metastases. Eur Radiol. 8(8):1345-51, 1998
                                              13. Ontell FK et al: Blastic osseous metastases in ovarian carcinoma. Can Assoc Radiol J. 46(3):231-4, 1995
                                              14. Olson EM et al: Osseous metastasis in medulloblastoma: MRI findings in an unusual case. Clin Imaging. 15(4):286-9, 1991
                                              15. Thrall JH et al: Skeletal metastases. Radiol Clin North Am. 25(6):1155-70, 1987
                                              16. Aoki J et al: Sclerotic bone metastasis: radiologic-pathologic correlation. Radiology. 159(1):127-32, 1986
                                              17. Galasko CS: Mechanisms of lytic and blastic metastatic disease of bone. Clin Orthop. (169):20-7, 1982
                                              18. Joffe N et al: Osteoblastic bone metastases secondary to adenocarcinoma of the pancreas. Clin Radiol. 29(1):41-6, 1978
                                              19. Kongtawng T et al: Radiographic evaluation of treatment of advanced carcinoma of the prostate. South Med J. 71(3):247-50, 1978
                                              20. Lokich JJ: Osseous metastases: radiographic monitoring of therapeutic response. Oncology. 35(6):274-6, 1978
                                              Related Anatomy
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                                              Related Differential Diagnoses
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                                              References
                                              Tables

                                              Tables

                                              KEY FACTS

                                              • Terminology

                                                • Imaging

                                                  • Top Differential Diagnoses

                                                    • Pathology

                                                      • Clinical Issues

                                                        TERMINOLOGY

                                                        • Synonyms

                                                          • Sclerotic metastases, osteosclerotic metastases, osteoblastic metastases
                                                        • Definitions

                                                          • Spread of primary tumor to spine where bone production exceeds bone destruction

                                                        IMAGING

                                                        • General Features

                                                          • Radiographic Findings

                                                            • CT Findings

                                                              • MR Findings

                                                                • Nuclear Medicine Findings

                                                                  • Imaging Recommendations

                                                                    DIFFERENTIAL DIAGNOSIS

                                                                      PATHOLOGY

                                                                      • General Features

                                                                        • Staging, Grading, & Classification

                                                                          • Gross Pathologic & Surgical Features

                                                                            • Microscopic Features

                                                                              CLINICAL ISSUES

                                                                              • Presentation

                                                                                • Demographics

                                                                                  • Natural History & Prognosis

                                                                                    • Treatment

                                                                                      DIAGNOSTIC CHECKLIST

                                                                                      • Consider

                                                                                        • Image Interpretation Pearls

                                                                                          Selected References

                                                                                          1. Dushyanthen S et al: The osteoblastic and osteoclastic interactions in spinal metastases secondary to prostate cancer. Cancer Growth Metastasis. 6:61-80, 2013
                                                                                          2. Goudarzi B et al: Detection of bone metastases using diffusion weighted magnetic resonance imaging: comparison with (11)C-methionine PET and bone scintigraphy. Magn Reson Imaging. 28(3):372-379, 2010
                                                                                          3. Borad MJ et al: Skeletal metastases in pancreatic cancer: a retrospective study and review of the literature. Yale J Biol Med. 82(1):1-6, 2009
                                                                                          4. Oztekin O et al: SSH-EPI diffusion-weighted MR imaging of the spine with low b values: is it useful in differentiating malignant metastatic tumor infiltration from benign fracture edema? Skeletal Radiol. 38(7):651-8, 2009
                                                                                          5. Israel O et al: FDG-PET and CT patterns of bone metastases and their relationship to previously administered anti-cancer therapy. Eur J Nucl Med Mol Imaging. 33(11):1280-4, 2006
                                                                                          6. Fogelman I et al: Positron emission tomography and bone metastases. Semin Nucl Med. 35(2):135-42, 2005
                                                                                          7. Nakai T et al: Pitfalls of FDG-PET for the diagnosis of osteoblastic bone metastases in patients with breast cancer. Eur J Nucl Med Mol Imaging. 32(11):1253-8, 2005
                                                                                          8. Tomita K et al: Surgical strategy for spinal metastases. Spine. 26(3):298-306, 2001
                                                                                          9. Wahl RL: Current status of PET in breast cancer imaging, staging, and therapy. Semin Roentgenol. 36(3):250-60, 2001
                                                                                          10. Castillo M et al: Diffusion-weighted MR imaging offers no advantage over routine noncontrast MR imaging in the detection of vertebral metastases. AJNR Am J Neuroradiol. 21(5):948-53, 2000
                                                                                          11. Chamberlain MC et al: Epidural spinal cord compression: a single institution's retrospective experience. Neuro Oncol. 1(2):120-3, 1999
                                                                                          12. Vanel D et al: MRI of bone metastases. Eur Radiol. 8(8):1345-51, 1998
                                                                                          13. Ontell FK et al: Blastic osseous metastases in ovarian carcinoma. Can Assoc Radiol J. 46(3):231-4, 1995
                                                                                          14. Olson EM et al: Osseous metastasis in medulloblastoma: MRI findings in an unusual case. Clin Imaging. 15(4):286-9, 1991
                                                                                          15. Thrall JH et al: Skeletal metastases. Radiol Clin North Am. 25(6):1155-70, 1987
                                                                                          16. Aoki J et al: Sclerotic bone metastasis: radiologic-pathologic correlation. Radiology. 159(1):127-32, 1986
                                                                                          17. Galasko CS: Mechanisms of lytic and blastic metastatic disease of bone. Clin Orthop. (169):20-7, 1982
                                                                                          18. Joffe N et al: Osteoblastic bone metastases secondary to adenocarcinoma of the pancreas. Clin Radiol. 29(1):41-6, 1978
                                                                                          19. Kongtawng T et al: Radiographic evaluation of treatment of advanced carcinoma of the prostate. South Med J. 71(3):247-50, 1978
                                                                                          20. Lokich JJ: Osseous metastases: radiographic monitoring of therapeutic response. Oncology. 35(6):274-6, 1978