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Bone Infarct
B.J. Manaster, MD, PhD, FACR
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KEY FACTS

  • Terminology

    • Imaging

      • Pathology

        • Diagnostic Checklist

          TERMINOLOGY

          • Synonyms

            • Osteonecrosis, avascular necrosis, aseptic necrosis
              • Terms used interchangeably; all refer to necrosis of bone
              • By convention, term bone infarct used when lesion is not in subchondral location
          • Definitions

            • Death of bone and marrow secondary to loss of blood supply

          IMAGING

          • General Features

            • Radiographic Findings

              • MR Findings

                • Nuclear Medicine Findings

                  DIFFERENTIAL DIAGNOSIS

                    PATHOLOGY

                    • General Features

                      CLINICAL ISSUES

                      • Presentation

                        • Demographics

                          • Natural History & Prognosis

                            • Treatment

                              DIAGNOSTIC CHECKLIST

                              • Consider

                                Selected References

                                1. Inusa BP et al: Dilemma in differentiating between acute osteomyelitis and bone infarction in children with sickle cell disease: the role of ultrasound. PLoS One. 8(6):e65001, 2013
                                2. Shafiq M et al: Bone marrow necrosis - initial presentation in sickle cell anemia. Am J Case Rep. 14:416-8, 2013
                                3. Dua SG et al: Bone infarct-associated sarcoma detected on FDG PET/CT. Clin Nucl Med. 36(3):218-20, 2011
                                4. Martinoli C et al: Musculoskeletal manifestations of chronic anemias. Semin Musculoskelet Radiol. 15(3):269-80, 2011
                                5. Salesi M et al: A case of SLE with bilateral osteonecrosis of femoral heads and bone infarct in distal of femur. Rheumatol Int. 30(4):527-9, 2010
                                6. Domson GF et al: Infarct-associated bone sarcomas. Clin Orthop Relat Res. 467(7):1820-5, 2009
                                7. Jaramillo D: What is the optimal imaging of osteonecrosis, Perthes, and bone infarcts? Pediatr Radiol. 39 Suppl 2:S216-9, 2009
                                8. Shapeero LG et al: Post-treatment complications of soft tissue tumours. Eur J Radiol. 69(2):209-21, 2009
                                9. Hara H et al: Magnetic resonance imaging of medullary bone infarction in the early stage. Clin Imaging. 32(2):147-51, 2008
                                10. Hermann G et al: Cystic degeneration of medullary bone infarction evaluated with magnetic resonance imaging correlated with pathologic examination. Can Assoc Radiol J. 55(5):321-5, 2004
                                Related Anatomy
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                                Related Differential Diagnoses
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                                References
                                Tables

                                Tables

                                KEY FACTS

                                • Terminology

                                  • Imaging

                                    • Pathology

                                      • Diagnostic Checklist

                                        TERMINOLOGY

                                        • Synonyms

                                          • Osteonecrosis, avascular necrosis, aseptic necrosis
                                            • Terms used interchangeably; all refer to necrosis of bone
                                            • By convention, term bone infarct used when lesion is not in subchondral location
                                        • Definitions

                                          • Death of bone and marrow secondary to loss of blood supply

                                        IMAGING

                                        • General Features

                                          • Radiographic Findings

                                            • MR Findings

                                              • Nuclear Medicine Findings

                                                DIFFERENTIAL DIAGNOSIS

                                                  PATHOLOGY

                                                  • General Features

                                                    CLINICAL ISSUES

                                                    • Presentation

                                                      • Demographics

                                                        • Natural History & Prognosis

                                                          • Treatment

                                                            DIAGNOSTIC CHECKLIST

                                                            • Consider

                                                              Selected References

                                                              1. Inusa BP et al: Dilemma in differentiating between acute osteomyelitis and bone infarction in children with sickle cell disease: the role of ultrasound. PLoS One. 8(6):e65001, 2013
                                                              2. Shafiq M et al: Bone marrow necrosis - initial presentation in sickle cell anemia. Am J Case Rep. 14:416-8, 2013
                                                              3. Dua SG et al: Bone infarct-associated sarcoma detected on FDG PET/CT. Clin Nucl Med. 36(3):218-20, 2011
                                                              4. Martinoli C et al: Musculoskeletal manifestations of chronic anemias. Semin Musculoskelet Radiol. 15(3):269-80, 2011
                                                              5. Salesi M et al: A case of SLE with bilateral osteonecrosis of femoral heads and bone infarct in distal of femur. Rheumatol Int. 30(4):527-9, 2010
                                                              6. Domson GF et al: Infarct-associated bone sarcomas. Clin Orthop Relat Res. 467(7):1820-5, 2009
                                                              7. Jaramillo D: What is the optimal imaging of osteonecrosis, Perthes, and bone infarcts? Pediatr Radiol. 39 Suppl 2:S216-9, 2009
                                                              8. Shapeero LG et al: Post-treatment complications of soft tissue tumours. Eur J Radiol. 69(2):209-21, 2009
                                                              9. Hara H et al: Magnetic resonance imaging of medullary bone infarction in the early stage. Clin Imaging. 32(2):147-51, 2008
                                                              10. Hermann G et al: Cystic degeneration of medullary bone infarction evaluated with magnetic resonance imaging correlated with pathologic examination. Can Assoc Radiol J. 55(5):321-5, 2004