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Spine
Diagnosis
Neoplasms, Cysts, and Other Masses
Systemic Disorders
Spinal Manifestations of Systemic Diseases
Bone Infarction
Bone Infarction
Kevin R. Moore, MD; Jeffrey S. Ross, MD
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KEY FACTS

  • Terminology

    • Imaging

      • Top Differential Diagnoses

        • Clinical Issues

          • Diagnostic Checklist

            TERMINOLOGY

            • Synonyms

              • Immature bone infarct, bone marrow infarction

            • Definitions

              • Infarction of vertebral body cancellous bone and marrow secondary to systemic disease or aortic pathology
              • Not osteonecrosis (Kümmell disease)

            IMAGING

            • General Features

              • Radiographic Findings

                • CT Findings

                  • MR Findings

                    DIFFERENTIAL DIAGNOSIS

                      PATHOLOGY

                      • Gross Pathologic & Surgical Features

                        CLINICAL ISSUES

                        • Presentation

                          DIAGNOSTIC CHECKLIST

                          • Consider

                            Selected References

                            1. Hughes D et al: Gaucher disease in bone: from pathophysiology to practice. J Bone Miner Res. 34(6):996-1013, 2019
                            2. Peckham ME et al: Imaging of vascular disorders of the spine. Radiol Clin North Am. 57(2):307-18, 2019
                            3. Watanabe M et al: Craniofacial bone infarcts in sickle cell disease: clinical and radiological manifestations. J Comput Assist Tomogr. 37(1):91-7, 2013
                            4. Shah LM et al: MRI of spinal bone marrow: part I, techniques and normal age-related appearances. AJR Am J Roentgenol. 197(6):1298-308, 2011
                            5. Tall MA et al: MR imaging of the spinal bone marrow. Magn Reson Imaging Clin N Am. 15(2):175-98, vi, 2007
                            6. Alyas F et al: MR imaging evaluation of the bone marrow and marrow infiltrative disorders of the lumbar spine. Magn Reson Imaging Clin N Am. 15(2):199-219, vi, 2007
                            7. Vazquez E et al: Neuroimaging in pediatric leukemia and lymphoma: differential diagnosis. Radiographics. 22(6):1411-28, 2002
                            8. Mori A et al: Avascular necrosis in the femoral head secondary to bone marrow infarction in a patient with graft-versus-host disease after unrelated bone marrow transplantation. Ann Hematol. 80(4):238-42, 2001
                            9. Butt WP: MRI diagnosis of bone marrow infarction in the child with leukaemia. Clin Radiol. 53(1):77, 1998
                            10. Mori A et al: Bone marrow infarction due to acute graft-versus-host disease in an acute lymphoblastic leukemia patient after unrelated bone marrow transplantation. Bone Marrow Transplant. 21(6):615-7, 1998
                            11. Amano Y et al: Case report: the MRI diagnosis of bone marrow infarction in a child with leukaemia. Clin Radiol. 52(7):560-2, 1997
                            12. Munk PL et al: Immature bone infarcts: findings on plain radiographs and MR scans. AJR Am J Roentgenol. 152(3):547-9, 1989
                            13. Bain B: Extensive bone marrow infarction followed by myelofibrosis in patient with Ph' positive chronic granulocytic leukaemia. J Clin Pathol. 33(5):449-53, 1980
                            Related Anatomy
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                            Related Differential Diagnoses
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                            References
                            Tables

                            Tables

                            KEY FACTS

                            • Terminology

                              • Imaging

                                • Top Differential Diagnoses

                                  • Clinical Issues

                                    • Diagnostic Checklist

                                      TERMINOLOGY

                                      • Synonyms

                                        • Immature bone infarct, bone marrow infarction

                                      • Definitions

                                        • Infarction of vertebral body cancellous bone and marrow secondary to systemic disease or aortic pathology
                                        • Not osteonecrosis (Kümmell disease)

                                      IMAGING

                                      • General Features

                                        • Radiographic Findings

                                          • CT Findings

                                            • MR Findings

                                              DIFFERENTIAL DIAGNOSIS

                                                PATHOLOGY

                                                • Gross Pathologic & Surgical Features

                                                  CLINICAL ISSUES

                                                  • Presentation

                                                    DIAGNOSTIC CHECKLIST

                                                    • Consider

                                                      Selected References

                                                      1. Hughes D et al: Gaucher disease in bone: from pathophysiology to practice. J Bone Miner Res. 34(6):996-1013, 2019
                                                      2. Peckham ME et al: Imaging of vascular disorders of the spine. Radiol Clin North Am. 57(2):307-18, 2019
                                                      3. Watanabe M et al: Craniofacial bone infarcts in sickle cell disease: clinical and radiological manifestations. J Comput Assist Tomogr. 37(1):91-7, 2013
                                                      4. Shah LM et al: MRI of spinal bone marrow: part I, techniques and normal age-related appearances. AJR Am J Roentgenol. 197(6):1298-308, 2011
                                                      5. Tall MA et al: MR imaging of the spinal bone marrow. Magn Reson Imaging Clin N Am. 15(2):175-98, vi, 2007
                                                      6. Alyas F et al: MR imaging evaluation of the bone marrow and marrow infiltrative disorders of the lumbar spine. Magn Reson Imaging Clin N Am. 15(2):199-219, vi, 2007
                                                      7. Vazquez E et al: Neuroimaging in pediatric leukemia and lymphoma: differential diagnosis. Radiographics. 22(6):1411-28, 2002
                                                      8. Mori A et al: Avascular necrosis in the femoral head secondary to bone marrow infarction in a patient with graft-versus-host disease after unrelated bone marrow transplantation. Ann Hematol. 80(4):238-42, 2001
                                                      9. Butt WP: MRI diagnosis of bone marrow infarction in the child with leukaemia. Clin Radiol. 53(1):77, 1998
                                                      10. Mori A et al: Bone marrow infarction due to acute graft-versus-host disease in an acute lymphoblastic leukemia patient after unrelated bone marrow transplantation. Bone Marrow Transplant. 21(6):615-7, 1998
                                                      11. Amano Y et al: Case report: the MRI diagnosis of bone marrow infarction in a child with leukaemia. Clin Radiol. 52(7):560-2, 1997
                                                      12. Munk PL et al: Immature bone infarcts: findings on plain radiographs and MR scans. AJR Am J Roentgenol. 152(3):547-9, 1989
                                                      13. Bain B: Extensive bone marrow infarction followed by myelofibrosis in patient with Ph' positive chronic granulocytic leukaemia. J Clin Pathol. 33(5):449-53, 1980