link
Bookmarks
Bone Neoplasms
Umesh D. Oza, MD; Daniel G. Hampton, MD
To access 4,300 diagnoses written by the world's leading experts in radiology, please log in or subscribe.Log inSubscribe
0
0
19
0

KEY FACTS

  • Imaging

    • Clinical Issues

      • Diagnostic Checklist

        TERMINOLOGY

        • Definitions

          • Malignant primary bone lesion
            • Osteosarcoma: Malignant cells of mesenchymal origin that produce osteoid
            • Ewing sarcoma: Primitive undifferentiated neoplasm; small, blue, round cell tumor
            • Chondrosarcoma: Heterogenous bone tumors; common trait of chondroid matrix production
            • Multiple myeloma: Neoplastic proliferation of plasma cells in bone marrow
          • Polyostotic: Affects multiple bones
            • Skeletal scintigraphy plays large role in polyostotic bones lesions to accurately assess extent of disease
          • Monostotic: Affects single bone
          • Differentiating monostotic from polyostotic is important to narrow differential diagnosis
          • Not all bone lesions fall into 1 category, rather can have variable presentation
        • Bone Imaging and Dysplasias

          • Malignant
            • Hot: Chondrosarcoma, Ewing sarcoma, osteosarcoma, metastases, adamantinoma
            • Cold: Multiple myeloma; metastases, purely lytic
          • Benign
            • Hot: Paget disease, osteoblastoma, chondroblastoma, aneurysmal bone cyst, osteoid osteoma, giant cell tumor
            • Isointense or mild: Fibrous dysplasia, fibrous cortical defect, nonossifying fibroma, enchondroma
            • Cold: Enostosis, osteopathia striata, bone cyst
            • Variable: Osteochondroma/multiple hereditary exostoses, Langerhans cell histiocytosis, hemangioma

        IMAGING

        • General Features

          • Nuclear Medicine Findings

            • Imaging Recommendations

              DIFFERENTIAL DIAGNOSIS

                PATHOLOGY

                • General Features

                  • Staging, Grading, & Classification

                    • Gross Pathologic & Surgical Features

                      CLINICAL ISSUES

                      • Presentation

                        • Demographics

                          DIAGNOSTIC CHECKLIST

                          • Consider

                            • Image Interpretation Pearls

                              Selected References

                              1. Costelloe CM et al: FDG PET/CT of primary bone tumors. AJR Am J Roentgenol. 202(6):W521-31, 2014
                              2. Kaste SC: Imaging pediatric bone sarcomas. Radiol Clin North Am. 49(4):749-65, vi-vii, 2011
                              3. Cook GJ et al: Miscellaneous indications in bone scintigraphy: metabolic bone diseases and malignant bone tumors. Semin Nucl Med. 40(1):52-61, 2010
                              4. Stacy GS et al: Staging of bone tumors: a review with illustrative examples. AJR Am J Roentgenol. 186(4):967-76, 2006
                              5. Levine SM et al: Cortical lesions of the tibia: characteristic appearances at conventional radiography. Radiographics. 23(1):157-77, 2003
                              6. Murphey MD et al: Imaging of osteochondroma: variants and complications with radiologic-pathologic correlation. Radiographics. 20(5):1407-34, 2000
                              7. Kransdorf MJ et al: Aneurysmal bone cyst: Concept, controversy, clinical presentation, and imaging. Am J Roentgenol 164:573-80, 1995
                              Related Anatomy
                              Loading...
                              Related Differential Diagnoses
                              Loading...
                              References
                              Tables

                              Tables

                              KEY FACTS

                              • Imaging

                                • Clinical Issues

                                  • Diagnostic Checklist

                                    TERMINOLOGY

                                    • Definitions

                                      • Malignant primary bone lesion
                                        • Osteosarcoma: Malignant cells of mesenchymal origin that produce osteoid
                                        • Ewing sarcoma: Primitive undifferentiated neoplasm; small, blue, round cell tumor
                                        • Chondrosarcoma: Heterogenous bone tumors; common trait of chondroid matrix production
                                        • Multiple myeloma: Neoplastic proliferation of plasma cells in bone marrow
                                      • Polyostotic: Affects multiple bones
                                        • Skeletal scintigraphy plays large role in polyostotic bones lesions to accurately assess extent of disease
                                      • Monostotic: Affects single bone
                                      • Differentiating monostotic from polyostotic is important to narrow differential diagnosis
                                      • Not all bone lesions fall into 1 category, rather can have variable presentation
                                    • Bone Imaging and Dysplasias

                                      • Malignant
                                        • Hot: Chondrosarcoma, Ewing sarcoma, osteosarcoma, metastases, adamantinoma
                                        • Cold: Multiple myeloma; metastases, purely lytic
                                      • Benign
                                        • Hot: Paget disease, osteoblastoma, chondroblastoma, aneurysmal bone cyst, osteoid osteoma, giant cell tumor
                                        • Isointense or mild: Fibrous dysplasia, fibrous cortical defect, nonossifying fibroma, enchondroma
                                        • Cold: Enostosis, osteopathia striata, bone cyst
                                        • Variable: Osteochondroma/multiple hereditary exostoses, Langerhans cell histiocytosis, hemangioma

                                    IMAGING

                                    • General Features

                                      • Nuclear Medicine Findings

                                        • Imaging Recommendations

                                          DIFFERENTIAL DIAGNOSIS

                                            PATHOLOGY

                                            • General Features

                                              • Staging, Grading, & Classification

                                                • Gross Pathologic & Surgical Features

                                                  CLINICAL ISSUES

                                                  • Presentation

                                                    • Demographics

                                                      DIAGNOSTIC CHECKLIST

                                                      • Consider

                                                        • Image Interpretation Pearls

                                                          Selected References

                                                          1. Costelloe CM et al: FDG PET/CT of primary bone tumors. AJR Am J Roentgenol. 202(6):W521-31, 2014
                                                          2. Kaste SC: Imaging pediatric bone sarcomas. Radiol Clin North Am. 49(4):749-65, vi-vii, 2011
                                                          3. Cook GJ et al: Miscellaneous indications in bone scintigraphy: metabolic bone diseases and malignant bone tumors. Semin Nucl Med. 40(1):52-61, 2010
                                                          4. Stacy GS et al: Staging of bone tumors: a review with illustrative examples. AJR Am J Roentgenol. 186(4):967-76, 2006
                                                          5. Levine SM et al: Cortical lesions of the tibia: characteristic appearances at conventional radiography. Radiographics. 23(1):157-77, 2003
                                                          6. Murphey MD et al: Imaging of osteochondroma: variants and complications with radiologic-pathologic correlation. Radiographics. 20(5):1407-34, 2000
                                                          7. Kransdorf MJ et al: Aneurysmal bone cyst: Concept, controversy, clinical presentation, and imaging. Am J Roentgenol 164:573-80, 1995