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Brunner Gland Hyperplasia
Michael P. Federle, MD, FACR; Amir A. Borhani, MD
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KEY FACTS

  • Terminology

    • Imaging

      • Top Differential Diagnoses

        • Clinical Issues

          TERMINOLOGY

          • Synonyms

            • Brunner gland hamartoma, Brunner gland adenoma (misnomer)
          • Definitions

            • Nonneoplastic hyperplasia of duodenal submucosal glands
              • Diffuse type (Brunner gland hyperplasia)
                • Multiple, small, submucosal nodules < 5 mm
              • Solitary type (Brunner gland hamartoma)
                • Solitary, sessile or pedunculated lesion > 5 mm

          IMAGING

          • General Features

            • Imaging Recommendations

              • Fluoroscopic Findings

                • Ultrasonographic Findings

                  • CT Findings

                    DIFFERENTIAL DIAGNOSIS

                      PATHOLOGY

                      • General Features

                        • Microscopic Features

                          CLINICAL ISSUES

                          • Presentation

                            • Demographics

                              • Treatment

                                Selected References

                                1. Chen KM et al: A duodenal tumor with intermittent obstruction. Brunner's gland hyperplasia. Gastroenterology. 146(4):e7-8, 2014
                                2. Kim K et al: Clinicopathologic characteristics and mucin expression in Brunner's gland proliferating lesions. Dig Dis Sci. 58(1):194-201, 2013
                                3. Pavlovic Markovic A et al: Endoscopic ultrasound for differential diagnosis of duodenal lesions. Ultraschall Med. 33(7):E210-7, 2012
                                4. Kini JR et al: Brunner's gland hamartoma and hyperplasia. Trop Gastroenterol. 31(2):121-3, 2010
                                5. Calva D et al: Hamartomatous polyposis syndromes. Surg Clin North Am. 88(4):779-817, vii, 2008
                                6. Hosogi H et al: Molecular insights into Peutz-Jeghers syndrome: two probands with a germline mutation of LKB1. J Gastroenterol. 43(6):492-7, 2008
                                7. Patel ND et al: Brunner's gland hyperplasia and hamartoma: imaging features with clinicopathologic correlation. AJR Am J Roentgenol. 187(3):715-22, 2006
                                Related Anatomy
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                                Related Differential Diagnoses
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                                References
                                Tables

                                Tables

                                KEY FACTS

                                • Terminology

                                  • Imaging

                                    • Top Differential Diagnoses

                                      • Clinical Issues

                                        TERMINOLOGY

                                        • Synonyms

                                          • Brunner gland hamartoma, Brunner gland adenoma (misnomer)
                                        • Definitions

                                          • Nonneoplastic hyperplasia of duodenal submucosal glands
                                            • Diffuse type (Brunner gland hyperplasia)
                                              • Multiple, small, submucosal nodules < 5 mm
                                            • Solitary type (Brunner gland hamartoma)
                                              • Solitary, sessile or pedunculated lesion > 5 mm

                                        IMAGING

                                        • General Features

                                          • Imaging Recommendations

                                            • Fluoroscopic Findings

                                              • Ultrasonographic Findings

                                                • CT Findings

                                                  DIFFERENTIAL DIAGNOSIS

                                                    PATHOLOGY

                                                    • General Features

                                                      • Microscopic Features

                                                        CLINICAL ISSUES

                                                        • Presentation

                                                          • Demographics

                                                            • Treatment

                                                              Selected References

                                                              1. Chen KM et al: A duodenal tumor with intermittent obstruction. Brunner's gland hyperplasia. Gastroenterology. 146(4):e7-8, 2014
                                                              2. Kim K et al: Clinicopathologic characteristics and mucin expression in Brunner's gland proliferating lesions. Dig Dis Sci. 58(1):194-201, 2013
                                                              3. Pavlovic Markovic A et al: Endoscopic ultrasound for differential diagnosis of duodenal lesions. Ultraschall Med. 33(7):E210-7, 2012
                                                              4. Kini JR et al: Brunner's gland hamartoma and hyperplasia. Trop Gastroenterol. 31(2):121-3, 2010
                                                              5. Calva D et al: Hamartomatous polyposis syndromes. Surg Clin North Am. 88(4):779-817, vii, 2008
                                                              6. Hosogi H et al: Molecular insights into Peutz-Jeghers syndrome: two probands with a germline mutation of LKB1. J Gastroenterol. 43(6):492-7, 2008
                                                              7. Patel ND et al: Brunner's gland hyperplasia and hamartoma: imaging features with clinicopathologic correlation. AJR Am J Roentgenol. 187(3):715-22, 2006