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Brunner Gland Hyperplasia
Atif Zaheer, MD; Michael P. Federle, MD, FACR
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KEY FACTS

  • Terminology

    • Imaging

      • Top Differential Diagnoses

        • Clinical Issues

          TERMINOLOGY

          • Synonyms

            • Brunner gland hamartoma, Brunner gland adenoma (misnomer)
          • Definitions

            • Nonneoplastic hyperplasia of duodenal submucosal glands
              • Diffuse type (Brunner gland hyperplasia)
                • Multiple, small, submucosal nodules < 5 mm
              • Solitary type (Brunner gland hamartoma)
                • Solitary sessile or pedunculated lesion > 5 mm

          IMAGING

          • General Features

            • MR Findings

              • Imaging Recommendations

                • Fluoroscopic Findings

                  • Ultrasonographic Findings

                    • CT Findings

                      DIFFERENTIAL DIAGNOSIS

                        PATHOLOGY

                        • General Features

                          • Microscopic Features

                            CLINICAL ISSUES

                            • Presentation

                              • Demographics

                                • Treatment

                                  Selected References

                                  1. Patel BN et al: Groove pancreatitis: a clinical and imaging overview. Abdom Radiol (NY). 45(5):1439-46, 2020
                                  2. Barat M et al: Mass-forming lesions of the duodenum: a pictorial review. Diagn Interv Imaging. 98(10):663-75, 2017
                                  3. Chen KM et al: A duodenal tumor with intermittent obstruction. Brunner's gland hyperplasia. Gastroenterology. 146(4):e7-8, 2014
                                  4. Kim K et al: Clinicopathologic characteristics and mucin expression in Brunner's gland proliferating lesions. Dig Dis Sci. 58(1):194-201, 2013
                                  5. Pavlovic Markovic A et al: Endoscopic ultrasound for differential diagnosis of duodenal lesions. Ultraschall Med. 33(7):E210-7, 2012
                                  6. Kini JR et al: Brunner's gland hamartoma and hyperplasia. Trop Gastroenterol. 31(2):121-3, 2010
                                  7. Calva D et al: Hamartomatous polyposis syndromes. Surg Clin North Am. 88(4):779-817, vii, 2008
                                  8. Hosogi H et al: Molecular insights into Peutz-Jeghers syndrome: two probands with a germline mutation of LKB1. J Gastroenterol. 43(6):492-7, 2008
                                  9. Patel ND et al: Brunner's gland hyperplasia and hamartoma: imaging features with clinicopathologic correlation. AJR Am J Roentgenol. 187(3):715-22, 2006
                                  Related Anatomy
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                                  Related Differential Diagnoses
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                                  References
                                  Tables

                                  Tables

                                  KEY FACTS

                                  • Terminology

                                    • Imaging

                                      • Top Differential Diagnoses

                                        • Clinical Issues

                                          TERMINOLOGY

                                          • Synonyms

                                            • Brunner gland hamartoma, Brunner gland adenoma (misnomer)
                                          • Definitions

                                            • Nonneoplastic hyperplasia of duodenal submucosal glands
                                              • Diffuse type (Brunner gland hyperplasia)
                                                • Multiple, small, submucosal nodules < 5 mm
                                              • Solitary type (Brunner gland hamartoma)
                                                • Solitary sessile or pedunculated lesion > 5 mm

                                          IMAGING

                                          • General Features

                                            • MR Findings

                                              • Imaging Recommendations

                                                • Fluoroscopic Findings

                                                  • Ultrasonographic Findings

                                                    • CT Findings

                                                      DIFFERENTIAL DIAGNOSIS

                                                        PATHOLOGY

                                                        • General Features

                                                          • Microscopic Features

                                                            CLINICAL ISSUES

                                                            • Presentation

                                                              • Demographics

                                                                • Treatment

                                                                  Selected References

                                                                  1. Patel BN et al: Groove pancreatitis: a clinical and imaging overview. Abdom Radiol (NY). 45(5):1439-46, 2020
                                                                  2. Barat M et al: Mass-forming lesions of the duodenum: a pictorial review. Diagn Interv Imaging. 98(10):663-75, 2017
                                                                  3. Chen KM et al: A duodenal tumor with intermittent obstruction. Brunner's gland hyperplasia. Gastroenterology. 146(4):e7-8, 2014
                                                                  4. Kim K et al: Clinicopathologic characteristics and mucin expression in Brunner's gland proliferating lesions. Dig Dis Sci. 58(1):194-201, 2013
                                                                  5. Pavlovic Markovic A et al: Endoscopic ultrasound for differential diagnosis of duodenal lesions. Ultraschall Med. 33(7):E210-7, 2012
                                                                  6. Kini JR et al: Brunner's gland hamartoma and hyperplasia. Trop Gastroenterol. 31(2):121-3, 2010
                                                                  7. Calva D et al: Hamartomatous polyposis syndromes. Surg Clin North Am. 88(4):779-817, vii, 2008
                                                                  8. Hosogi H et al: Molecular insights into Peutz-Jeghers syndrome: two probands with a germline mutation of LKB1. J Gastroenterol. 43(6):492-7, 2008
                                                                  9. Patel ND et al: Brunner's gland hyperplasia and hamartoma: imaging features with clinicopathologic correlation. AJR Am J Roentgenol. 187(3):715-22, 2006