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Calcifying Aponeurotic Fibroma
Eric Walker, MD, MHA, FACR, FACHE; Catherine C. Roberts, MD; Behrang Amini, MD, PhD
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KEY FACTS

  • Terminology

    • Imaging

      • Pathology

        • Clinical Issues

          TERMINOLOGY

          • Synonyms

            • Juvenile aponeurotic fibroma, aponeurotic fibroma
          • Definitions

            • Benign, locally aggressive fibroblastic lesion of childhood; usually on distal extremities
            • Characterized by bland spindle cells and less cellular zones of calcification with plump epithelioid fibroblasts

          IMAGING

          • General Features

            • Imaging Recommendations

              • Radiographic Findings

                • CT Findings

                  • MR Findings

                    DIFFERENTIAL DIAGNOSIS

                      PATHOLOGY

                      • General Features

                        • Gross Pathologic & Surgical Features

                          • Microscopic Features

                            CLINICAL ISSUES

                            • Presentation

                              • Demographics

                                • Natural History & Prognosis

                                  • Treatment

                                    Selected References

                                    1. Kao YC et al: What is new about the molecular genetics in matrix-producing soft tissue tumors? The contributions to pathogenetic understanding and diagnostic classification. Virchows Arch. 476(1):121-34, 2020
                                    2. Puls F et al: Calcifying aponeurotic fibroma. In Fletcher CDM et al: WHO Classification of Tumours: Soft Tissue and Bone Tumours. 5th ed. IARC Press. 74-5, 2020
                                    3. Kwee RM et al: Calcified or ossified benign soft tissue lesions that may simulate malignancy. Skeletal Radiol. 48(12):1875-90, 2019
                                    4. Shim SW et al: MRI features of calcifying aponeurotic fibroma in the upper arm: a case report and review of the literature. Skeletal Radiol. 45(8):1139-43, 2016
                                    5. Cho YH et al: Calcifying aponeurotic fibroma of the dorsum of the foot: radiographic and magnetic resonance imaging findings in a four-year-old boy. Iran J Radiol. 12(2):e23911, 2015
                                    6. Kransdorf MJ et al: Fibrous and fibrohistiocytic tumors. In Kransdorf MJ et al: Imaging of Soft Tissue Tumors. 3rd ed. Lippincott Williams & Wilkins. 261-2, 2014
                                    7. Kim OH et al: Calcifying aponeurotic fibroma: case report with radiographic and MR features. Korean J Radiol. 15(1):134-9, 2014
                                    8. Murphey MD et al: From the archives of the AFIP: musculoskeletal fibromatoses: radiologic-pathologic correlation. Radiographics. 29(7):2143-73, 2009
                                    9. Weiss SW et al: Fibrous tumors of infancy and childhood. In Weiss SW et al: Enzinger and Weiss' Soft Tissue Tumors. 5th ed. Elsevier. 289-93, 2008
                                    10. Kim DH et al: Acute median-nerve compression caused by calcifying aponeurotic fibroma. Am J Phys Med Rehabil. 85(12):1017-8, 2006
                                    11. Parker WL et al: Calcifying aponeurotic fibroma of the hand: radiologic differentiation from giant cell tumors of the tendon sheath. J Hand Surg Am. 31(6):1024-8, 2006
                                    12. Kwak HS et al: MR imaging of calcifying aponeurotic fibroma of the thigh. Pediatr Radiol. 34(5):438-40, 2004
                                    13. Farshid G et al: Calcifying aponeurotic fibroma. In Fletcher CDM et al: WHO Classification of Tumours. Pathology and Genetics of Tumours of Soft Tissue and Bone. IARC Press. 69-70, 2002
                                    14. Fetsch JF et al: Calcifying aponeurotic fibroma: a clinicopathologic study of 22 cases arising in uncommon sites. Hum Pathol. 29(12):1504-10, 1998
                                    Related Anatomy
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                                    Related Differential Diagnoses
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                                    References
                                    Tables

                                    Tables

                                    KEY FACTS

                                    • Terminology

                                      • Imaging

                                        • Pathology

                                          • Clinical Issues

                                            TERMINOLOGY

                                            • Synonyms

                                              • Juvenile aponeurotic fibroma, aponeurotic fibroma
                                            • Definitions

                                              • Benign, locally aggressive fibroblastic lesion of childhood; usually on distal extremities
                                              • Characterized by bland spindle cells and less cellular zones of calcification with plump epithelioid fibroblasts

                                            IMAGING

                                            • General Features

                                              • Imaging Recommendations

                                                • Radiographic Findings

                                                  • CT Findings

                                                    • MR Findings

                                                      DIFFERENTIAL DIAGNOSIS

                                                        PATHOLOGY

                                                        • General Features

                                                          • Gross Pathologic & Surgical Features

                                                            • Microscopic Features

                                                              CLINICAL ISSUES

                                                              • Presentation

                                                                • Demographics

                                                                  • Natural History & Prognosis

                                                                    • Treatment

                                                                      Selected References

                                                                      1. Kao YC et al: What is new about the molecular genetics in matrix-producing soft tissue tumors? The contributions to pathogenetic understanding and diagnostic classification. Virchows Arch. 476(1):121-34, 2020
                                                                      2. Puls F et al: Calcifying aponeurotic fibroma. In Fletcher CDM et al: WHO Classification of Tumours: Soft Tissue and Bone Tumours. 5th ed. IARC Press. 74-5, 2020
                                                                      3. Kwee RM et al: Calcified or ossified benign soft tissue lesions that may simulate malignancy. Skeletal Radiol. 48(12):1875-90, 2019
                                                                      4. Shim SW et al: MRI features of calcifying aponeurotic fibroma in the upper arm: a case report and review of the literature. Skeletal Radiol. 45(8):1139-43, 2016
                                                                      5. Cho YH et al: Calcifying aponeurotic fibroma of the dorsum of the foot: radiographic and magnetic resonance imaging findings in a four-year-old boy. Iran J Radiol. 12(2):e23911, 2015
                                                                      6. Kransdorf MJ et al: Fibrous and fibrohistiocytic tumors. In Kransdorf MJ et al: Imaging of Soft Tissue Tumors. 3rd ed. Lippincott Williams & Wilkins. 261-2, 2014
                                                                      7. Kim OH et al: Calcifying aponeurotic fibroma: case report with radiographic and MR features. Korean J Radiol. 15(1):134-9, 2014
                                                                      8. Murphey MD et al: From the archives of the AFIP: musculoskeletal fibromatoses: radiologic-pathologic correlation. Radiographics. 29(7):2143-73, 2009
                                                                      9. Weiss SW et al: Fibrous tumors of infancy and childhood. In Weiss SW et al: Enzinger and Weiss' Soft Tissue Tumors. 5th ed. Elsevier. 289-93, 2008
                                                                      10. Kim DH et al: Acute median-nerve compression caused by calcifying aponeurotic fibroma. Am J Phys Med Rehabil. 85(12):1017-8, 2006
                                                                      11. Parker WL et al: Calcifying aponeurotic fibroma of the hand: radiologic differentiation from giant cell tumors of the tendon sheath. J Hand Surg Am. 31(6):1024-8, 2006
                                                                      12. Kwak HS et al: MR imaging of calcifying aponeurotic fibroma of the thigh. Pediatr Radiol. 34(5):438-40, 2004
                                                                      13. Farshid G et al: Calcifying aponeurotic fibroma. In Fletcher CDM et al: WHO Classification of Tumours. Pathology and Genetics of Tumours of Soft Tissue and Bone. IARC Press. 69-70, 2002
                                                                      14. Fetsch JF et al: Calcifying aponeurotic fibroma: a clinicopathologic study of 22 cases arising in uncommon sites. Hum Pathol. 29(12):1504-10, 1998