link
Bookmarks
Canavan Disease
Surjith Vattoth, MD, FRCR; P. Ellen Grant, MD
To access 4,300 diagnoses written by the world's leading experts in radiology, please log in or subscribe.Log inSubscribe
0
5
7
2

KEY FACTS

  • Terminology

    • Imaging

      • Top Differential Diagnoses

        • Pathology

          • Clinical Issues

            • Diagnostic Checklist

              TERMINOLOGY

              • Abbreviations

                • Canavan disease (CD)
              • Synonyms

                • Spongiform leukodystrophy, aspartoacylase deficiency
                • Spongy degeneration of CNS, Canavan-van Bogaert-Bertrand disease, ASPA deficiency, ASP deficiency, aminoacylase 2 deficiency, ACY2 deficiency
              • Definitions

                • Progressive fatal autosomal-recessive spongiform leukodystrophy

              IMAGING

              • General Features

                • CT Findings

                  • MR Findings

                    • Ultrasonographic Findings

                      • Imaging Recommendations

                        DIFFERENTIAL DIAGNOSIS

                          PATHOLOGY

                          • General Features

                            • Staging, Grading, & Classification

                              • Gross Pathologic & Surgical Features

                                • Microscopic Features

                                  CLINICAL ISSUES

                                  • Presentation

                                    • Demographics

                                      • Natural History & Prognosis

                                        • Treatment

                                          DIAGNOSTIC CHECKLIST

                                          • Image Interpretation Pearls

                                            Selected References

                                            1. Jauhari P et al: Juvenile Canavan disease: a leukodystrophy without white matter changes. Neuropediatrics. 49(6):420-1, 2018
                                            2. Guo F et al: Ablating N-acetylaspartate prevents leukodystrophy in a Canavan disease model. Ann Neurol. 77(5):884-8, 2015
                                            3. Baslow MH et al: Canavan disease, a rare early-onset human spongiform leukodystrophy: insights into its genesis and possible clinical interventions. Biochimie. 95(4):946-56, 2013
                                            4. van der Knaap MS et al: Defining and categorizing leukoencephalopathies of unknown origin: MR imaging approach. Radiology. 213(1):121-33, 1999
                                            Related Anatomy
                                            Loading...
                                            Related Differential Diagnoses
                                            Loading...
                                            References
                                            Tables

                                            Tables

                                            KEY FACTS

                                            • Terminology

                                              • Imaging

                                                • Top Differential Diagnoses

                                                  • Pathology

                                                    • Clinical Issues

                                                      • Diagnostic Checklist

                                                        TERMINOLOGY

                                                        • Abbreviations

                                                          • Canavan disease (CD)
                                                        • Synonyms

                                                          • Spongiform leukodystrophy, aspartoacylase deficiency
                                                          • Spongy degeneration of CNS, Canavan-van Bogaert-Bertrand disease, ASPA deficiency, ASP deficiency, aminoacylase 2 deficiency, ACY2 deficiency
                                                        • Definitions

                                                          • Progressive fatal autosomal-recessive spongiform leukodystrophy

                                                        IMAGING

                                                        • General Features

                                                          • CT Findings

                                                            • MR Findings

                                                              • Ultrasonographic Findings

                                                                • Imaging Recommendations

                                                                  DIFFERENTIAL DIAGNOSIS

                                                                    PATHOLOGY

                                                                    • General Features

                                                                      • Staging, Grading, & Classification

                                                                        • Gross Pathologic & Surgical Features

                                                                          • Microscopic Features

                                                                            CLINICAL ISSUES

                                                                            • Presentation

                                                                              • Demographics

                                                                                • Natural History & Prognosis

                                                                                  • Treatment

                                                                                    DIAGNOSTIC CHECKLIST

                                                                                    • Image Interpretation Pearls

                                                                                      Selected References

                                                                                      1. Jauhari P et al: Juvenile Canavan disease: a leukodystrophy without white matter changes. Neuropediatrics. 49(6):420-1, 2018
                                                                                      2. Guo F et al: Ablating N-acetylaspartate prevents leukodystrophy in a Canavan disease model. Ann Neurol. 77(5):884-8, 2015
                                                                                      3. Baslow MH et al: Canavan disease, a rare early-onset human spongiform leukodystrophy: insights into its genesis and possible clinical interventions. Biochimie. 95(4):946-56, 2013
                                                                                      4. van der Knaap MS et al: Defining and categorizing leukoencephalopathies of unknown origin: MR imaging approach. Radiology. 213(1):121-33, 1999