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Capillary Telangiectasia
Anne G. Osborn, MD, FACR
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KEY FACTS

  • Terminology

    • Imaging

      • Top Differential Diagnoses

        • Clinical Issues

          TERMINOLOGY

          • Abbreviations

            • Brain capillary telangiectasia (BCT)
            • Cerebrovascular malformation (CVM)
          • Synonyms

            • Capillary malformation
            • Not capillary "hemangioma"
              • Hemangiomas are true benign vasoformative neoplasms
              • Usually in face, scalp, back, chest, orbit
              • Less common: Dura, venous sinuses
              • Exceptionally rare in brain parenchyma
          • Definitions

            • Cluster of enlarged, dilated capillaries interspersed with normal brain parenchyma

          IMAGING

          • General Features

            • CT Findings

              • MR Findings

                • Angiographic Findings

                  • Imaging Recommendations

                    DIFFERENTIAL DIAGNOSIS

                      PATHOLOGY

                      • General Features

                        • Gross Pathologic & Surgical Features

                          • Microscopic Features

                            CLINICAL ISSUES

                            • Presentation

                              • Demographics

                                • Natural History & Prognosis

                                  • Treatment

                                    DIAGNOSTIC CHECKLIST

                                    • Image Interpretation Pearls

                                      Selected References

                                      1. Gross BA et al: Cerebral capillary telangiectasias: a meta-analysis and review of the literature. Neurosurg Rev. 36(2):187-93; discussion 194, 2013
                                      2. El-Koussy M et al: Susceptibility-weighted MR imaging for diagnosis of capillary telangiectasia of the brain. AJNR Am J Neuroradiol. 33(4):715-20, 2012
                                      3. Ozcan HN et al: MRI findings in giant pontine capillary telangiectasis associated with a developmental venous anomaly. JBR-BTR. 94(5):293-4, 2011
                                      4. Gao P et al: Nonischemic cerebral venous hypertension promotes a pro-angiogenic stage through HIF-1 downstream genes and leukocyte-derived MMP-9. J Cereb Blood Flow Metab. 29(8):1482-90, 2009
                                      5. Govani FS et al: Hereditary haemorrhagic telangiectasia: a clinical and scientific review. Eur J Hum Genet. 17(7):860-71, 2009
                                      6. Gripp KW et al: Significant overlap and possible identity of macrocephaly capillary malformation and megalencephaly polymicrogyria-polydactyly hydrocephalus syndromes. Am J Med Genet A. 149A(5):868-76, 2009
                                      7. Hao Q et al: Increased tissue perfusion promotes capillary dysplasia in the ALK1-deficient mouse brain following VEGF stimulation. Am J Physiol Heart Circ Physiol. 295(6):H2250-6, 2008
                                      8. Pozzati E et al: The neurovascular triad: mixed cavernous, capillary, and venous malformations of the brainstem. J Neurosurg. 107(6):1113-9, 2007
                                      9. Koike S et al: Asymptomatic radiation-induced telangiectasia in children after cranial irradiation: frequency, latency, and dose relation. Radiology. 230(1):93-9, 2004
                                      10. Castillo M et al: MR imaging and histologic features of capillary telangiectasia of the basal ganglia. AJNR Am J Neuroradiol. 22(8):1553-5, 2001
                                      Related Anatomy
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                                      Related Differential Diagnoses
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                                      References
                                      Tables

                                      Tables

                                      KEY FACTS

                                      • Terminology

                                        • Imaging

                                          • Top Differential Diagnoses

                                            • Clinical Issues

                                              TERMINOLOGY

                                              • Abbreviations

                                                • Brain capillary telangiectasia (BCT)
                                                • Cerebrovascular malformation (CVM)
                                              • Synonyms

                                                • Capillary malformation
                                                • Not capillary "hemangioma"
                                                  • Hemangiomas are true benign vasoformative neoplasms
                                                  • Usually in face, scalp, back, chest, orbit
                                                  • Less common: Dura, venous sinuses
                                                  • Exceptionally rare in brain parenchyma
                                              • Definitions

                                                • Cluster of enlarged, dilated capillaries interspersed with normal brain parenchyma

                                              IMAGING

                                              • General Features

                                                • CT Findings

                                                  • MR Findings

                                                    • Angiographic Findings

                                                      • Imaging Recommendations

                                                        DIFFERENTIAL DIAGNOSIS

                                                          PATHOLOGY

                                                          • General Features

                                                            • Gross Pathologic & Surgical Features

                                                              • Microscopic Features

                                                                CLINICAL ISSUES

                                                                • Presentation

                                                                  • Demographics

                                                                    • Natural History & Prognosis

                                                                      • Treatment

                                                                        DIAGNOSTIC CHECKLIST

                                                                        • Image Interpretation Pearls

                                                                          Selected References

                                                                          1. Gross BA et al: Cerebral capillary telangiectasias: a meta-analysis and review of the literature. Neurosurg Rev. 36(2):187-93; discussion 194, 2013
                                                                          2. El-Koussy M et al: Susceptibility-weighted MR imaging for diagnosis of capillary telangiectasia of the brain. AJNR Am J Neuroradiol. 33(4):715-20, 2012
                                                                          3. Ozcan HN et al: MRI findings in giant pontine capillary telangiectasis associated with a developmental venous anomaly. JBR-BTR. 94(5):293-4, 2011
                                                                          4. Gao P et al: Nonischemic cerebral venous hypertension promotes a pro-angiogenic stage through HIF-1 downstream genes and leukocyte-derived MMP-9. J Cereb Blood Flow Metab. 29(8):1482-90, 2009
                                                                          5. Govani FS et al: Hereditary haemorrhagic telangiectasia: a clinical and scientific review. Eur J Hum Genet. 17(7):860-71, 2009
                                                                          6. Gripp KW et al: Significant overlap and possible identity of macrocephaly capillary malformation and megalencephaly polymicrogyria-polydactyly hydrocephalus syndromes. Am J Med Genet A. 149A(5):868-76, 2009
                                                                          7. Hao Q et al: Increased tissue perfusion promotes capillary dysplasia in the ALK1-deficient mouse brain following VEGF stimulation. Am J Physiol Heart Circ Physiol. 295(6):H2250-6, 2008
                                                                          8. Pozzati E et al: The neurovascular triad: mixed cavernous, capillary, and venous malformations of the brainstem. J Neurosurg. 107(6):1113-9, 2007
                                                                          9. Koike S et al: Asymptomatic radiation-induced telangiectasia in children after cranial irradiation: frequency, latency, and dose relation. Radiology. 230(1):93-9, 2004
                                                                          10. Castillo M et al: MR imaging and histologic features of capillary telangiectasia of the basal ganglia. AJNR Am J Neuroradiol. 22(8):1553-5, 2001