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Cardiac Lymphoma
John P. Lichtenberger, III, MD
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KEY FACTS

  • Terminology

    • Imaging

      • Top Differential Diagnoses

        • Clinical Issues

          • Diagnostic Checklist

            TERMINOLOGY

            • Abbreviations

              • Non-Hodgkin lymphoma (NHL)
            • Definitions

              • Primary cardiac lymphoma (PCL)
                • Confined to heart and pericardium without extracardiac disease
                • Rare; majority occur in patients with HIV/AIDS
              • Secondary cardiac lymphoma (SCL)
                • Cardiac involvement in patients with systemic lymphoma
                • ~ 1/3 of patients with lymphoma develop secondary cardiac lymphoma (pathology series)
              • Primary effusion lymphoma (PEL)
                • Rare; HIV-associated NHL
                • Lymphomatous growth in liquid phase in body cavities, such as pericardium
                • Evidence of infection by human herpesvirus-8, which is associated with Kaposi sarcoma

            IMAGING

            • General Features

              • Radiographic Findings

                • CT Findings

                  • MR Findings

                    • Echocardiographic Findings

                      • Imaging Recommendations

                        • Nuclear Medicine Findings

                          DIFFERENTIAL DIAGNOSIS

                            PATHOLOGY

                            • General Features

                              • Gross Pathologic & Surgical Features

                                • Microscopic Features

                                  CLINICAL ISSUES

                                  • Presentation

                                    • Demographics

                                      • Natural History & Prognosis

                                        • Treatment

                                          DIAGNOSTIC CHECKLIST

                                          • Consider

                                            • Image Interpretation Pearls

                                              Selected References

                                              1. Carter BW et al: Multimodality imaging of cardiothoracic lymphoma. Eur J Radiol. 83(8):1470-82, 2014
                                              2. Miller PE et al: The drowning heart: an ambiguous lymphoma. Am J Med. 127(9):817-9, 2014
                                              3. Jeudy J et al: From the radiologic pathology archives: cardiac lymphoma: radiologic-pathologic correlation. Radiographics. 32(5):1369-80, 2012
                                              4. Shah RN et al: Primary cardiac lymphoma diagnosed by multiphase-gated cardiac CT and CT-guided percutaneous trans-sternal biopsy. J Cardiovasc Comput Tomogr. 6(2):137-9, 2012
                                              5. Paes FM et al: FDG PET/CT of extranodal involvement in non-Hodgkin lymphoma and Hodgkin disease. Radiographics. 30(1):269-91, 2010
                                              Related Anatomy
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                                              Related Differential Diagnoses
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                                              References
                                              Tables

                                              Tables

                                              KEY FACTS

                                              • Terminology

                                                • Imaging

                                                  • Top Differential Diagnoses

                                                    • Clinical Issues

                                                      • Diagnostic Checklist

                                                        TERMINOLOGY

                                                        • Abbreviations

                                                          • Non-Hodgkin lymphoma (NHL)
                                                        • Definitions

                                                          • Primary cardiac lymphoma (PCL)
                                                            • Confined to heart and pericardium without extracardiac disease
                                                            • Rare; majority occur in patients with HIV/AIDS
                                                          • Secondary cardiac lymphoma (SCL)
                                                            • Cardiac involvement in patients with systemic lymphoma
                                                            • ~ 1/3 of patients with lymphoma develop secondary cardiac lymphoma (pathology series)
                                                          • Primary effusion lymphoma (PEL)
                                                            • Rare; HIV-associated NHL
                                                            • Lymphomatous growth in liquid phase in body cavities, such as pericardium
                                                            • Evidence of infection by human herpesvirus-8, which is associated with Kaposi sarcoma

                                                        IMAGING

                                                        • General Features

                                                          • Radiographic Findings

                                                            • CT Findings

                                                              • MR Findings

                                                                • Echocardiographic Findings

                                                                  • Imaging Recommendations

                                                                    • Nuclear Medicine Findings

                                                                      DIFFERENTIAL DIAGNOSIS

                                                                        PATHOLOGY

                                                                        • General Features

                                                                          • Gross Pathologic & Surgical Features

                                                                            • Microscopic Features

                                                                              CLINICAL ISSUES

                                                                              • Presentation

                                                                                • Demographics

                                                                                  • Natural History & Prognosis

                                                                                    • Treatment

                                                                                      DIAGNOSTIC CHECKLIST

                                                                                      • Consider

                                                                                        • Image Interpretation Pearls

                                                                                          Selected References

                                                                                          1. Carter BW et al: Multimodality imaging of cardiothoracic lymphoma. Eur J Radiol. 83(8):1470-82, 2014
                                                                                          2. Miller PE et al: The drowning heart: an ambiguous lymphoma. Am J Med. 127(9):817-9, 2014
                                                                                          3. Jeudy J et al: From the radiologic pathology archives: cardiac lymphoma: radiologic-pathologic correlation. Radiographics. 32(5):1369-80, 2012
                                                                                          4. Shah RN et al: Primary cardiac lymphoma diagnosed by multiphase-gated cardiac CT and CT-guided percutaneous trans-sternal biopsy. J Cardiovasc Comput Tomogr. 6(2):137-9, 2012
                                                                                          5. Paes FM et al: FDG PET/CT of extranodal involvement in non-Hodgkin lymphoma and Hodgkin disease. Radiographics. 30(1):269-91, 2010