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Castleman Disease
Brett W. Carter, MD, CPPS
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KEY FACTS

  • Terminology

    • Imaging

      • Top Differential Diagnoses

        • Pathology

          • Clinical Issues

            TERMINOLOGY

            • Abbreviations

              • Castleman disease (CD)
            • Synonyms

              • Angiofollicular lymph node hyperplasia
              • Giant lymph node hyperplasia

            IMAGING

            • General Features

              • Radiographic Findings

                • CT Findings

                  • MR Findings

                    • Nuclear Medicine Findings

                      • Imaging Recommendations

                        DIFFERENTIAL DIAGNOSIS

                          PATHOLOGY

                          • General Features

                            • Staging, Grading, & Classification

                              • Gross Pathologic & Surgical Features

                                • Microscopic Features

                                  CLINICAL ISSUES

                                  • Presentation

                                    • Demographics

                                      • Treatment

                                        Selected References

                                        1. Epstein D et al: Multicentric Castleman disease presenting as a chylous pleural effusion. Pathol Res Pract. 216(11):153209, 2020
                                        2. Chen MT et al: Unusual presentation of Castleman's disease mimicking lung cancer. Respirol Case Rep. 7(4):e00416, 2019
                                        3. Gamble EL et al: Spontaneous middle lobe torsion in a patient with multicentric Castleman disease: a case report. J Med Imaging Radiat Oncol. 63(2):225-7, 2019
                                        4. Zhao S et al: Imaging and clinical features of Castleman disease. Cancer Imaging. 19(1):53, 2019
                                        5. Haap M et al: Clinical, laboratory and imaging findings in Castleman's disease - the subtype decides. Blood Rev. 32(3):225-34, 2018
                                        6. Wong RSM: Unicentric Castleman disease. Hematol Oncol Clin North Am. 32(1):65-73, 2018
                                        7. Kligerman SJ et al: Castleman Disease of the thorax: clinical, radiologic, and pathologic correlation: from the radiologic pathology archives. Radiographics. 36(5):1309-32, 2016
                                        8. Cohen A et al: Kaposi's sarcoma-associated herpesvirus: clinical, diagnostic, and epidemiological aspects. Crit Rev Clin Lab Sci. 42(2):101-53, 2005
                                        9. Gupta NK et al: Mediastinal Castleman disease mimicking mediastinal pulmonary sequestration. J Thorac Imaging. 20(3):229-32, 2005
                                        10. Ko SF et al: Imaging features of atypical thoracic Castleman disease. Clin Imaging. 28(4):280-5, 2004
                                        11. Ko SF et al: Imaging spectrum of Castleman's disease. AJR Am J Roentgenol. 182(3):769-75, 2004
                                        Related Anatomy
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                                        Related Differential Diagnoses
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                                        References
                                        Tables

                                        Tables

                                        KEY FACTS

                                        • Terminology

                                          • Imaging

                                            • Top Differential Diagnoses

                                              • Pathology

                                                • Clinical Issues

                                                  TERMINOLOGY

                                                  • Abbreviations

                                                    • Castleman disease (CD)
                                                  • Synonyms

                                                    • Angiofollicular lymph node hyperplasia
                                                    • Giant lymph node hyperplasia

                                                  IMAGING

                                                  • General Features

                                                    • Radiographic Findings

                                                      • CT Findings

                                                        • MR Findings

                                                          • Nuclear Medicine Findings

                                                            • Imaging Recommendations

                                                              DIFFERENTIAL DIAGNOSIS

                                                                PATHOLOGY

                                                                • General Features

                                                                  • Staging, Grading, & Classification

                                                                    • Gross Pathologic & Surgical Features

                                                                      • Microscopic Features

                                                                        CLINICAL ISSUES

                                                                        • Presentation

                                                                          • Demographics

                                                                            • Treatment

                                                                              Selected References

                                                                              1. Epstein D et al: Multicentric Castleman disease presenting as a chylous pleural effusion. Pathol Res Pract. 216(11):153209, 2020
                                                                              2. Chen MT et al: Unusual presentation of Castleman's disease mimicking lung cancer. Respirol Case Rep. 7(4):e00416, 2019
                                                                              3. Gamble EL et al: Spontaneous middle lobe torsion in a patient with multicentric Castleman disease: a case report. J Med Imaging Radiat Oncol. 63(2):225-7, 2019
                                                                              4. Zhao S et al: Imaging and clinical features of Castleman disease. Cancer Imaging. 19(1):53, 2019
                                                                              5. Haap M et al: Clinical, laboratory and imaging findings in Castleman's disease - the subtype decides. Blood Rev. 32(3):225-34, 2018
                                                                              6. Wong RSM: Unicentric Castleman disease. Hematol Oncol Clin North Am. 32(1):65-73, 2018
                                                                              7. Kligerman SJ et al: Castleman Disease of the thorax: clinical, radiologic, and pathologic correlation: from the radiologic pathology archives. Radiographics. 36(5):1309-32, 2016
                                                                              8. Cohen A et al: Kaposi's sarcoma-associated herpesvirus: clinical, diagnostic, and epidemiological aspects. Crit Rev Clin Lab Sci. 42(2):101-53, 2005
                                                                              9. Gupta NK et al: Mediastinal Castleman disease mimicking mediastinal pulmonary sequestration. J Thorac Imaging. 20(3):229-32, 2005
                                                                              10. Ko SF et al: Imaging features of atypical thoracic Castleman disease. Clin Imaging. 28(4):280-5, 2004
                                                                              11. Ko SF et al: Imaging spectrum of Castleman's disease. AJR Am J Roentgenol. 182(3):769-75, 2004