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Cat-Scratch Disease
A. Carlson Merrow, Jr., MD, FAAP
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KEY FACTS

  • Terminology

    • Imaging

      • Top Differential Diagnoses

        • Clinical Issues

          • Diagnostic Checklist

            TERMINOLOGY

            • Definitions

              • Cat-scratch disease (CSD): Spectrum of clinical manifestations resulting from Bartonella henselae inoculation of skin by cat scratch
              • "Typical CSD" (most common clinical presentation): Tender regional adenopathy + fever 1-3 weeks after inoculation
                • Papule at scratch site may be 1st clue
                • Self-limited in most patients
                • Disseminated disease in 5-14%

            IMAGING

            • General Features

              • Imaging Recommendations

                DIFFERENTIAL DIAGNOSIS

                  PATHOLOGY

                  • General Features

                    • Microscopic Features

                      CLINICAL ISSUES

                      • Presentation

                        • Demographics

                          • Natural History & Prognosis

                            • Treatment

                              DIAGNOSTIC CHECKLIST

                              • Image Interpretation Pearls

                                Selected References

                                1. Landes M et al: Cat scratch disease presenting as fever of unknown origin is a unique clinical syndrome. Clin Infect Dis. 71(11):2818-24, 2020
                                2. Cheslock MA et al: Human bartonellosis: an underappreciated public health problem? Trop Med Infect Dis. 4(2), 2019
                                3. Ksiaa I et al: Update on Bartonella neuroretinitis. J Curr Ophthalmol. 31(3):254-61, 2019
                                4. Chang CC et al: Disseminated cat-scratch disease: case report and review of the literature. Paediatr Int Child Health. 36(3):232-4, 2015
                                5. Kraft KE et al: Hepatosplenic cat-scratch disease in children and the positive contribution of 18F-FDG imaging. Clin Nucl Med. 40(9):746-7, 2015
                                6. Mazur-Melewska K et al: Cat-scratch disease: a wide spectrum of clinical pictures. Postepy Dermatol Alergol. 32(3):216-20, 2015
                                7. Melville DM et al: Sonography of cat scratch disease. J Ultrasound Med. 34(3):387-94, 2015
                                8. Rohr A et al: Spectrum of radiological manifestations of paediatric cat-scratch disease. Pediatr Radiol. 42(11):1380-4, 2012
                                9. Klotz SA et al: Cat-scratch disease. Am Fam Physician. 83(2):152-5, 2011
                                10. Florin TA et al: Beyond cat scratch disease: widening spectrum of Bartonella henselae infection. Pediatrics. 121(5):e1413-25, 2008
                                11. Scolfaro C et al: Prolonged follow up of seven patients affected by hepatosplenic granulomata due to cat-scratch disease. Eur J Pediatr. 167(4):471-3, 2008
                                12. Massei F et al: The expanded spectrum of bartonellosis in children. Infect Dis Clin North Am. 19(3):691-711, 2005
                                Related Anatomy
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                                Related Differential Diagnoses
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                                References
                                Tables

                                Tables

                                KEY FACTS

                                • Terminology

                                  • Imaging

                                    • Top Differential Diagnoses

                                      • Clinical Issues

                                        • Diagnostic Checklist

                                          TERMINOLOGY

                                          • Definitions

                                            • Cat-scratch disease (CSD): Spectrum of clinical manifestations resulting from Bartonella henselae inoculation of skin by cat scratch
                                            • "Typical CSD" (most common clinical presentation): Tender regional adenopathy + fever 1-3 weeks after inoculation
                                              • Papule at scratch site may be 1st clue
                                              • Self-limited in most patients
                                              • Disseminated disease in 5-14%

                                          IMAGING

                                          • General Features

                                            • Imaging Recommendations

                                              DIFFERENTIAL DIAGNOSIS

                                                PATHOLOGY

                                                • General Features

                                                  • Microscopic Features

                                                    CLINICAL ISSUES

                                                    • Presentation

                                                      • Demographics

                                                        • Natural History & Prognosis

                                                          • Treatment

                                                            DIAGNOSTIC CHECKLIST

                                                            • Image Interpretation Pearls

                                                              Selected References

                                                              1. Landes M et al: Cat scratch disease presenting as fever of unknown origin is a unique clinical syndrome. Clin Infect Dis. 71(11):2818-24, 2020
                                                              2. Cheslock MA et al: Human bartonellosis: an underappreciated public health problem? Trop Med Infect Dis. 4(2), 2019
                                                              3. Ksiaa I et al: Update on Bartonella neuroretinitis. J Curr Ophthalmol. 31(3):254-61, 2019
                                                              4. Chang CC et al: Disseminated cat-scratch disease: case report and review of the literature. Paediatr Int Child Health. 36(3):232-4, 2015
                                                              5. Kraft KE et al: Hepatosplenic cat-scratch disease in children and the positive contribution of 18F-FDG imaging. Clin Nucl Med. 40(9):746-7, 2015
                                                              6. Mazur-Melewska K et al: Cat-scratch disease: a wide spectrum of clinical pictures. Postepy Dermatol Alergol. 32(3):216-20, 2015
                                                              7. Melville DM et al: Sonography of cat scratch disease. J Ultrasound Med. 34(3):387-94, 2015
                                                              8. Rohr A et al: Spectrum of radiological manifestations of paediatric cat-scratch disease. Pediatr Radiol. 42(11):1380-4, 2012
                                                              9. Klotz SA et al: Cat-scratch disease. Am Fam Physician. 83(2):152-5, 2011
                                                              10. Florin TA et al: Beyond cat scratch disease: widening spectrum of Bartonella henselae infection. Pediatrics. 121(5):e1413-25, 2008
                                                              11. Scolfaro C et al: Prolonged follow up of seven patients affected by hepatosplenic granulomata due to cat-scratch disease. Eur J Pediatr. 167(4):471-3, 2008
                                                              12. Massei F et al: The expanded spectrum of bartonellosis in children. Infect Dis Clin North Am. 19(3):691-711, 2005