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Central Neurocytoma
Karen L. Salzman, MD
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KEY FACTS

  • Terminology

    • Imaging

      • Top Differential Diagnoses

        • Clinical Issues

          TERMINOLOGY

          • Abbreviations

            • Central neurocytoma (CN)
          • Synonyms

            • Neurocytoma
          • Definitions

            • Intraventricular neuroepithelial tumor with neuronal differentiation
            • Well-demarcated, intraventricular, neurocytic neoplasm located in foramen of Monro region

          IMAGING

          • General Features

            • CT Findings

              • MR Findings

                • Angiographic Findings

                  • Nuclear Medicine Findings

                    • Imaging Recommendations

                      DIFFERENTIAL DIAGNOSIS

                        PATHOLOGY

                        • General Features

                          • Staging, Grading, & Classification

                            • Gross Pathologic & Surgical Features

                              • Microscopic Features

                                CLINICAL ISSUES

                                • Presentation

                                  • Demographics

                                    • Natural History & Prognosis

                                      • Treatment

                                        DIAGNOSTIC CHECKLIST

                                        • Consider

                                          • Image Interpretation Pearls

                                            Selected References

                                            1. Hung YC et al: Stereotactic radiosurgery for central neurocytomas: an international multicenter retrospective cohort study. J Neurosurg. 1-10, 2020
                                            2. Mahavadi AK et al: Central neurocytoma treatment modalities: A systematic review assessing the outcomes of combined maximal safe resection and radiotherapy with gross total resection. World Neurosurg. ePub, 2020
                                            3. Sun PF et al: Application of diffusion-weighted imaging combined with apparent diffusion coefficient in differential diagnosis between central neurocytoma and ependymoma. Neuroradiology. 62(4):439-45, 2020
                                            4. Taschner CA et al: Freiburg Neuropathology Case Conference : Intraventricular Mass Lesion in a Child. Clin Neuroradiol. 30(1):189-195, 2020
                                            5. Johnson MO et al: The role of chemotherapy in the treatment of central neurocytoma. CNS Oncol. 8(3):CNS41, 2019
                                            6. Muly S et al: MRI of intracranial intraventricular lesions. Clin Imaging. 52:226-39, 2018
                                            7. Su C et al: Relative survival of patients with central neurocytoma. J Clin Neurosci. 55:123-4, 2018
                                            8. Louis DN et al: WHO Classification of Tumours of the Central Nervous System:Central neurocytoma. Lyon: IARC Press. 106-9, 2016
                                            9. Bonney PA et al: Histology and molecular aspects of central neurocytoma. Neurosurg Clin N Am. 26(1):21-9, 2015
                                            10. Choudhri O et al: Atypical and rare variants of central neurocytomas. Neurosurg Clin N Am. 26(1):91-8, 2015
                                            11. Donoho D et al: Imaging of central neurocytomas. Neurosurg Clin N Am. 26(1):11-9, 2015
                                            12. Phi JH et al: Rare pediatric central neurocytomas. Neurosurg Clin N Am. 26(1):105-8, 2015
                                            13. Chen YD et al: Long-term outcomes of adjuvant radiotherapy after surgical resection of central neurocytoma. Radiat Oncol. 9:242, 2014
                                            14. Tlili-Graiess K et al: Diffusion weighted MR imaging and proton MR spectroscopy findings of central neurocytoma with pathological correlation. J Neuroradiol. 41(4):243-50, 2014
                                            15. Kim JW et al: Radiosurgery for central neurocytoma: long-term outcome and failure pattern. J Neurooncol. 115(3):505-11, 2013
                                            16. Patel DM et al: Update on the diagnosis, pathogenesis, and treatment strategies for central neurocytoma. J Clin Neurosci. 20(9):1193-9, 2013
                                            17. Kocaoglu M et al: Central neurocytoma: proton MR spectroscopy and diffusion weighted MR imaging findings. Magn Reson Imaging. 27(3):434-40, 2009
                                            18. Romano A et al: Endoscopic removal of a central neurocytoma from the posterior third ventricle. J Clin Neurosci. 16(2):312-6, 2009
                                            19. Amini E et al: Central neurocytoma responsive to topotecan, ifosfamide, carboplatin. Pediatr Blood Cancer. 51(1):137-40, 2008
                                            20. Chen CL et al: Central neurocytoma: a clinical, radiological and pathological study of nine cases. Clin Neurol Neurosurg. 110(2):129-36, 2008
                                            21. Chen CM et al: Central neurocytoma: 9 case series and review. Surg Neurol. 70(2):204-9, 2008
                                            22. Kerkovsk√Ĺ M et al: Central neurocytoma: the neuroradiological perspective. Childs Nerv Syst. 24(11):1361-9, 2008
                                            23. Paek SH et al: Long-term outcome of conventional radiation therapy for central neurocytoma. J Neurooncol. 90(1):25-30, 2008
                                            24. Yeh IB et al: Central neurocytoma: typical magnetic resonance spectroscopy findings and atypical ventricular dissemination. Magn Reson Imaging. 26(1):59-64, 2008
                                            25. Krishnamoorthy T et al: Alanine peak in central neurocytomas on proton MR spectroscopy. Neuroradiology. 49(7):551-4, 2007
                                            26. Leenstra JL et al: Central neurocytoma: management recommendations based on a 35-year experience. Int J Radiat Oncol Biol Phys. 67(4):1145-54, 2007
                                            27. Ogawa Y et al: Central neurocytomas with MIB-1 labeling index over 10% showing rapid tumor growth and dissemination. J Neurooncol. 79(2):211-6, 2006
                                            28. Rades D et al: Value of postoperative stereotactic radiosurgery and conventional radiotherapy for incompletely resected typical neurocytomas. Cancer. 106(5):1140-3, 2006
                                            29. Rajesh LS et al: Central neurocytoma: a clinico-pathological study of eight cases. Indian J Pathol Microbiol. 49(4):543-5, 2006
                                            30. Zhang D et al: Central neurocytoma: clinical, pathological and neuroradiological findings. Clin Radiol. 61(4):348-57, 2006
                                            31. Chuang MT et al: 3-T proton magnetic resonance spectroscopy of central neurocytoma: 3 case reports and review of the literature. J Comput Assist Tomogr. 29(5):683-8, 2005
                                            32. Cultrera F et al: Central neurocytoma of the fourth ventricle. Case history. J Neurosurg Sci. 49(3):125-8, 2005
                                            33. Gallina P et al: Haemorrhagic central neurocytoma of the fourth ventricle. Acta Neurochir (Wien). 147(11):1193-4; discussion 1194, 2005
                                            34. Smets K et al: Central neurocytoma presenting with intraventricular hemorrhage: case report and review of literature. Acta Neurol Belg. 105(4):218-25, 2005
                                            35. Schmidt MH et al: Central neurocytoma: a review. J Neurooncol. 66(3):377-84, 2004
                                            36. Takao H et al: Central neurocytoma with craniospinal dissemination. J Neurooncol. 61(3):255-9, 2003
                                            37. Ando K et al: Central neurocytoma with craniospinal dissemination. Magn Reson Med Sci. 1(3):179-82, 2002
                                            38. Burger PC et al: Surgical pathology of nervous system and its coverings: The Brain: Tumors. 4th ed. Philadelphia: Churchill Livingstone. 250-4, 2002
                                            39. Kanamori M et al: (201)Tl-SPECT, (1)H-MRS, and MIB-1 labeling index of central neurocytomas: three case reports. Acta Neurochir (Wien). 144(2):157-63; discussion 163, 2002
                                            40. Koeller KK et al: From the archives of the AFIP. Cerebral intraventricular neoplasms: radiologic-pathologic correlation. Radiographics. 22(6):1473-505, 2002
                                            41. Kulkarni V et al: Long-term outcome in patients with central neurocytoma following stereotactic biopsy and radiation therapy. Br J Neurosurg. 16(2):126-32, 2002
                                            42. Ohtani T et al: Central neurocytoma with unusually intense FDG uptake: case report. Ann Nucl Med. 15(2):161-5, 2001
                                            43. Brandes AA et al: Chemotherapy in patients with recurrent and progressive central neurocytoma. Cancer. 88(1):169-74, 2000
                                            44. Figarella-Branger D et al: Pathology and Genetics of Tumours of the Nervous System: Central neurocytoma. Lyon: IARC Press. 107-9, 2000
                                            45. Kim DG et al: In vivo proton magnetic resonance spectroscopy of central neurocytomas. Neurosurgery. 46(2):329-33; discussion 333-4, 2000
                                            Related Anatomy
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                                            Related Differential Diagnoses
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                                            References
                                            Tables

                                            Tables

                                            KEY FACTS

                                            • Terminology

                                              • Imaging

                                                • Top Differential Diagnoses

                                                  • Clinical Issues

                                                    TERMINOLOGY

                                                    • Abbreviations

                                                      • Central neurocytoma (CN)
                                                    • Synonyms

                                                      • Neurocytoma
                                                    • Definitions

                                                      • Intraventricular neuroepithelial tumor with neuronal differentiation
                                                      • Well-demarcated, intraventricular, neurocytic neoplasm located in foramen of Monro region

                                                    IMAGING

                                                    • General Features

                                                      • CT Findings

                                                        • MR Findings

                                                          • Angiographic Findings

                                                            • Nuclear Medicine Findings

                                                              • Imaging Recommendations

                                                                DIFFERENTIAL DIAGNOSIS

                                                                  PATHOLOGY

                                                                  • General Features

                                                                    • Staging, Grading, & Classification

                                                                      • Gross Pathologic & Surgical Features

                                                                        • Microscopic Features

                                                                          CLINICAL ISSUES

                                                                          • Presentation

                                                                            • Demographics

                                                                              • Natural History & Prognosis

                                                                                • Treatment

                                                                                  DIAGNOSTIC CHECKLIST

                                                                                  • Consider

                                                                                    • Image Interpretation Pearls

                                                                                      Selected References

                                                                                      1. Hung YC et al: Stereotactic radiosurgery for central neurocytomas: an international multicenter retrospective cohort study. J Neurosurg. 1-10, 2020
                                                                                      2. Mahavadi AK et al: Central neurocytoma treatment modalities: A systematic review assessing the outcomes of combined maximal safe resection and radiotherapy with gross total resection. World Neurosurg. ePub, 2020
                                                                                      3. Sun PF et al: Application of diffusion-weighted imaging combined with apparent diffusion coefficient in differential diagnosis between central neurocytoma and ependymoma. Neuroradiology. 62(4):439-45, 2020
                                                                                      4. Taschner CA et al: Freiburg Neuropathology Case Conference : Intraventricular Mass Lesion in a Child. Clin Neuroradiol. 30(1):189-195, 2020
                                                                                      5. Johnson MO et al: The role of chemotherapy in the treatment of central neurocytoma. CNS Oncol. 8(3):CNS41, 2019
                                                                                      6. Muly S et al: MRI of intracranial intraventricular lesions. Clin Imaging. 52:226-39, 2018
                                                                                      7. Su C et al: Relative survival of patients with central neurocytoma. J Clin Neurosci. 55:123-4, 2018
                                                                                      8. Louis DN et al: WHO Classification of Tumours of the Central Nervous System:Central neurocytoma. Lyon: IARC Press. 106-9, 2016
                                                                                      9. Bonney PA et al: Histology and molecular aspects of central neurocytoma. Neurosurg Clin N Am. 26(1):21-9, 2015
                                                                                      10. Choudhri O et al: Atypical and rare variants of central neurocytomas. Neurosurg Clin N Am. 26(1):91-8, 2015
                                                                                      11. Donoho D et al: Imaging of central neurocytomas. Neurosurg Clin N Am. 26(1):11-9, 2015
                                                                                      12. Phi JH et al: Rare pediatric central neurocytomas. Neurosurg Clin N Am. 26(1):105-8, 2015
                                                                                      13. Chen YD et al: Long-term outcomes of adjuvant radiotherapy after surgical resection of central neurocytoma. Radiat Oncol. 9:242, 2014
                                                                                      14. Tlili-Graiess K et al: Diffusion weighted MR imaging and proton MR spectroscopy findings of central neurocytoma with pathological correlation. J Neuroradiol. 41(4):243-50, 2014
                                                                                      15. Kim JW et al: Radiosurgery for central neurocytoma: long-term outcome and failure pattern. J Neurooncol. 115(3):505-11, 2013
                                                                                      16. Patel DM et al: Update on the diagnosis, pathogenesis, and treatment strategies for central neurocytoma. J Clin Neurosci. 20(9):1193-9, 2013
                                                                                      17. Kocaoglu M et al: Central neurocytoma: proton MR spectroscopy and diffusion weighted MR imaging findings. Magn Reson Imaging. 27(3):434-40, 2009
                                                                                      18. Romano A et al: Endoscopic removal of a central neurocytoma from the posterior third ventricle. J Clin Neurosci. 16(2):312-6, 2009
                                                                                      19. Amini E et al: Central neurocytoma responsive to topotecan, ifosfamide, carboplatin. Pediatr Blood Cancer. 51(1):137-40, 2008
                                                                                      20. Chen CL et al: Central neurocytoma: a clinical, radiological and pathological study of nine cases. Clin Neurol Neurosurg. 110(2):129-36, 2008
                                                                                      21. Chen CM et al: Central neurocytoma: 9 case series and review. Surg Neurol. 70(2):204-9, 2008
                                                                                      22. Kerkovsk√Ĺ M et al: Central neurocytoma: the neuroradiological perspective. Childs Nerv Syst. 24(11):1361-9, 2008
                                                                                      23. Paek SH et al: Long-term outcome of conventional radiation therapy for central neurocytoma. J Neurooncol. 90(1):25-30, 2008
                                                                                      24. Yeh IB et al: Central neurocytoma: typical magnetic resonance spectroscopy findings and atypical ventricular dissemination. Magn Reson Imaging. 26(1):59-64, 2008
                                                                                      25. Krishnamoorthy T et al: Alanine peak in central neurocytomas on proton MR spectroscopy. Neuroradiology. 49(7):551-4, 2007
                                                                                      26. Leenstra JL et al: Central neurocytoma: management recommendations based on a 35-year experience. Int J Radiat Oncol Biol Phys. 67(4):1145-54, 2007
                                                                                      27. Ogawa Y et al: Central neurocytomas with MIB-1 labeling index over 10% showing rapid tumor growth and dissemination. J Neurooncol. 79(2):211-6, 2006
                                                                                      28. Rades D et al: Value of postoperative stereotactic radiosurgery and conventional radiotherapy for incompletely resected typical neurocytomas. Cancer. 106(5):1140-3, 2006
                                                                                      29. Rajesh LS et al: Central neurocytoma: a clinico-pathological study of eight cases. Indian J Pathol Microbiol. 49(4):543-5, 2006
                                                                                      30. Zhang D et al: Central neurocytoma: clinical, pathological and neuroradiological findings. Clin Radiol. 61(4):348-57, 2006
                                                                                      31. Chuang MT et al: 3-T proton magnetic resonance spectroscopy of central neurocytoma: 3 case reports and review of the literature. J Comput Assist Tomogr. 29(5):683-8, 2005
                                                                                      32. Cultrera F et al: Central neurocytoma of the fourth ventricle. Case history. J Neurosurg Sci. 49(3):125-8, 2005
                                                                                      33. Gallina P et al: Haemorrhagic central neurocytoma of the fourth ventricle. Acta Neurochir (Wien). 147(11):1193-4; discussion 1194, 2005
                                                                                      34. Smets K et al: Central neurocytoma presenting with intraventricular hemorrhage: case report and review of literature. Acta Neurol Belg. 105(4):218-25, 2005
                                                                                      35. Schmidt MH et al: Central neurocytoma: a review. J Neurooncol. 66(3):377-84, 2004
                                                                                      36. Takao H et al: Central neurocytoma with craniospinal dissemination. J Neurooncol. 61(3):255-9, 2003
                                                                                      37. Ando K et al: Central neurocytoma with craniospinal dissemination. Magn Reson Med Sci. 1(3):179-82, 2002
                                                                                      38. Burger PC et al: Surgical pathology of nervous system and its coverings: The Brain: Tumors. 4th ed. Philadelphia: Churchill Livingstone. 250-4, 2002
                                                                                      39. Kanamori M et al: (201)Tl-SPECT, (1)H-MRS, and MIB-1 labeling index of central neurocytomas: three case reports. Acta Neurochir (Wien). 144(2):157-63; discussion 163, 2002
                                                                                      40. Koeller KK et al: From the archives of the AFIP. Cerebral intraventricular neoplasms: radiologic-pathologic correlation. Radiographics. 22(6):1473-505, 2002
                                                                                      41. Kulkarni V et al: Long-term outcome in patients with central neurocytoma following stereotactic biopsy and radiation therapy. Br J Neurosurg. 16(2):126-32, 2002
                                                                                      42. Ohtani T et al: Central neurocytoma with unusually intense FDG uptake: case report. Ann Nucl Med. 15(2):161-5, 2001
                                                                                      43. Brandes AA et al: Chemotherapy in patients with recurrent and progressive central neurocytoma. Cancer. 88(1):169-74, 2000
                                                                                      44. Figarella-Branger D et al: Pathology and Genetics of Tumours of the Nervous System: Central neurocytoma. Lyon: IARC Press. 107-9, 2000
                                                                                      45. Kim DG et al: In vivo proton magnetic resonance spectroscopy of central neurocytomas. Neurosurgery. 46(2):329-33; discussion 333-4, 2000