Enlargement and destruction of respiratory bronchioles near center of secondary pulmonary lobule
IMAGING
General Features
Radiographic Findings
CT Findings
Imaging Recommendations
MR Findings
DIFFERENTIAL DIAGNOSIS
PATHOLOGY
General Features
Staging, Grading, & Classification
Gross Pathologic & Surgical Features
Microscopic Features
CLINICAL ISSUES
Presentation
Demographics
Natural History & Prognosis
Treatment
DIAGNOSTIC CHECKLIST
Image Interpretation Pearls
Selected References
El Kaddouri B et al: Fleischner Society visual emphysema CT patterns help predict progression of emphysema in current and former smokers: results from the COPDGene study. Radiology. 298(2):441-9, 2021
Martini K et al: Advances in imaging for lung emphysema. Ann Transl Med. 8(21):1467, 2020
Bhatt SP et al: Imaging advances in chronic obstructive pulmonary disease. insights from the genetic epidemiology of chronic obstructive pulmonary disease (COPDGene) study. Am J Respir Crit Care Med. 199(3):286-301, 2019
Hochhegger B et al: Pulmonary acinus: understanding the computed tomography findings from an acinar perspective. Lung. 197(3):259-65, 2019
Lynch DA et al: CT-based visual classification of emphysema: association with mortality in the COPDGene study. Radiology. 288(3):859-66, 2018
Tanabe N et al: Analysis of airway pathology in COPD using a combination of computed tomography, micro-computed tomography and histology. Eur Respir J. 51(2), 2018
Tanabe N et al: Micro-computed tomography comparison of preterminal bronchioles in centrilobular and panlobular emphysema. Am J Respir Crit Care Med. 195(5):630-8, 2017
Corrections. Lancet Respir Med. 4(11):e55, 2016
Ostridge K et al: Distinct emphysema subtypes defined by quantitative CT analysis are associated with specific pulmonary matrix metalloproteinases. Respir Res. 17(1):92, 2016
Lynch DA et al: CT-definable subtypes of chronic obstructive pulmonary disease: a statement of the Fleischner Society. Radiology. 277(1):192-205, 2015
Smith BM et al: Pulmonary emphysema subtypes on computed tomography: the MESA COPD study. Am J Med. 127(1):94.e7-23, 2014
Gietema HA et al: Quantifying the extent of emphysema: factors associated with radiologists' estimations and quantitative indices of emphysema severity using the ECLIPSE cohort. Acad Radiol. 18(6):661-71, 2011
Mets OM et al: Identification of chronic obstructive pulmonary disease in lung cancer screening computed tomographic scans. JAMA. 306(16):1775-81, 2011
Gietema HA et al: Distribution of emphysema in heavy smokers: impact on pulmonary function. Respir Med. 104(1):76-82, 2010
Sciurba FC et al: A randomized study of endobronchial valves for advanced emphysema. N Engl J Med. 363(13):1233-44, 2010
Akira M et al: Quantitative CT in chronic obstructive pulmonary disease: inspiratory and expiratory assessment. AJR Am J Roentgenol. 192(1):267-72, 2009
Litmanovich D et al: CT of pulmonary emphysema--current status, challenges, and future directions. Eur Radiol. 19(3):537-51, 2009
Ohno Y et al: Oxygen-enhanced magnetic resonance imaging versus computed tomography: multicenter study for clinical stage classification of smoking-related chronic obstructive pulmonary disease. Am J Respir Crit Care Med. 177(10):1095-102, 2008
Parraga G et al: Hyperpolarized 3He ventilation defects and apparent diffusion coefficients in chronic obstructive pulmonary disease: preliminary results at 3.0 Tesla. Invest Radiol. 42(6):384-91, 2007
Watz H et al: Micro-CT of the human lung: imaging of alveoli and virtual endoscopy of an alveolar duct in a normal lung and in a lung with centrilobular emphysema--initial observations. Radiology. 236(3):1053-8, 2005
Bankier AA et al: CT quantification of pulmonary emphysema: assessment of lung structure and function. Crit Rev Comput Tomogr. 43(6):399-417, 2002
Sugi K et al: The outcome of volume reduction surgery according to the underlying type of emphysema. Surg Today. 31(7):580-5, 2001
Bankier AA et al: Pulmonary emphysema: subjective visual grading versus objective quantification with macroscopic morphometry and thin-section CT densitometry. Radiology. 211(3):851-8, 1999
Slone RM et al: Preoperative and postoperative imaging in the surgical management of pulmonary emphysema. Radiol Clin North Am. 36(1):57-89, 1998
Webb WR: Radiology of obstructive pulmonary disease. AJR Am J Roentgenol. 169(3):637-47, 1997
Stern EJ et al: CT of the lungs in patients with pulmonary emphysema. Semin Ultrasound CT MR. 16(5):345-52, 1995
Related Anatomy
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References
Tables
Tables
KEY FACTS
Terminology
Imaging
Top Differential Diagnoses
Pathology
Clinical Issues
TERMINOLOGY
Abbreviations
Centrilobular emphysema (CLE)
Synonyms
Centriacinar emphysema
Proximal acinar emphysema
Definitions
Enlargement and destruction of respiratory bronchioles near center of secondary pulmonary lobule
IMAGING
General Features
Radiographic Findings
CT Findings
Imaging Recommendations
MR Findings
DIFFERENTIAL DIAGNOSIS
PATHOLOGY
General Features
Staging, Grading, & Classification
Gross Pathologic & Surgical Features
Microscopic Features
CLINICAL ISSUES
Presentation
Demographics
Natural History & Prognosis
Treatment
DIAGNOSTIC CHECKLIST
Image Interpretation Pearls
Selected References
El Kaddouri B et al: Fleischner Society visual emphysema CT patterns help predict progression of emphysema in current and former smokers: results from the COPDGene study. Radiology. 298(2):441-9, 2021
Martini K et al: Advances in imaging for lung emphysema. Ann Transl Med. 8(21):1467, 2020
Bhatt SP et al: Imaging advances in chronic obstructive pulmonary disease. insights from the genetic epidemiology of chronic obstructive pulmonary disease (COPDGene) study. Am J Respir Crit Care Med. 199(3):286-301, 2019
Hochhegger B et al: Pulmonary acinus: understanding the computed tomography findings from an acinar perspective. Lung. 197(3):259-65, 2019
Lynch DA et al: CT-based visual classification of emphysema: association with mortality in the COPDGene study. Radiology. 288(3):859-66, 2018
Tanabe N et al: Analysis of airway pathology in COPD using a combination of computed tomography, micro-computed tomography and histology. Eur Respir J. 51(2), 2018
Tanabe N et al: Micro-computed tomography comparison of preterminal bronchioles in centrilobular and panlobular emphysema. Am J Respir Crit Care Med. 195(5):630-8, 2017
Corrections. Lancet Respir Med. 4(11):e55, 2016
Ostridge K et al: Distinct emphysema subtypes defined by quantitative CT analysis are associated with specific pulmonary matrix metalloproteinases. Respir Res. 17(1):92, 2016
Lynch DA et al: CT-definable subtypes of chronic obstructive pulmonary disease: a statement of the Fleischner Society. Radiology. 277(1):192-205, 2015
Smith BM et al: Pulmonary emphysema subtypes on computed tomography: the MESA COPD study. Am J Med. 127(1):94.e7-23, 2014
Gietema HA et al: Quantifying the extent of emphysema: factors associated with radiologists' estimations and quantitative indices of emphysema severity using the ECLIPSE cohort. Acad Radiol. 18(6):661-71, 2011
Mets OM et al: Identification of chronic obstructive pulmonary disease in lung cancer screening computed tomographic scans. JAMA. 306(16):1775-81, 2011
Gietema HA et al: Distribution of emphysema in heavy smokers: impact on pulmonary function. Respir Med. 104(1):76-82, 2010
Sciurba FC et al: A randomized study of endobronchial valves for advanced emphysema. N Engl J Med. 363(13):1233-44, 2010
Akira M et al: Quantitative CT in chronic obstructive pulmonary disease: inspiratory and expiratory assessment. AJR Am J Roentgenol. 192(1):267-72, 2009
Litmanovich D et al: CT of pulmonary emphysema--current status, challenges, and future directions. Eur Radiol. 19(3):537-51, 2009
Ohno Y et al: Oxygen-enhanced magnetic resonance imaging versus computed tomography: multicenter study for clinical stage classification of smoking-related chronic obstructive pulmonary disease. Am J Respir Crit Care Med. 177(10):1095-102, 2008
Parraga G et al: Hyperpolarized 3He ventilation defects and apparent diffusion coefficients in chronic obstructive pulmonary disease: preliminary results at 3.0 Tesla. Invest Radiol. 42(6):384-91, 2007
Watz H et al: Micro-CT of the human lung: imaging of alveoli and virtual endoscopy of an alveolar duct in a normal lung and in a lung with centrilobular emphysema--initial observations. Radiology. 236(3):1053-8, 2005
Bankier AA et al: CT quantification of pulmonary emphysema: assessment of lung structure and function. Crit Rev Comput Tomogr. 43(6):399-417, 2002
Sugi K et al: The outcome of volume reduction surgery according to the underlying type of emphysema. Surg Today. 31(7):580-5, 2001
Bankier AA et al: Pulmonary emphysema: subjective visual grading versus objective quantification with macroscopic morphometry and thin-section CT densitometry. Radiology. 211(3):851-8, 1999
Slone RM et al: Preoperative and postoperative imaging in the surgical management of pulmonary emphysema. Radiol Clin North Am. 36(1):57-89, 1998
Webb WR: Radiology of obstructive pulmonary disease. AJR Am J Roentgenol. 169(3):637-47, 1997
Stern EJ et al: CT of the lungs in patients with pulmonary emphysema. Semin Ultrasound CT MR. 16(5):345-52, 1995
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