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KEY FACTS
Terminology
Imaging
Top Differential Diagnoses
Pathology
Clinical Issues
TERMINOLOGY
Abbreviations
- Centrilobular emphysema (CLE)
Synonyms
- Centriacinar emphysema
- Proximal acinar emphysema
Definitions
- Enlargement and destruction of respiratory bronchioles near center of secondary pulmonary lobule
IMAGING
General Features
Radiographic Findings
CT Findings
Imaging Recommendations
MR Findings
DIFFERENTIAL DIAGNOSIS
PATHOLOGY
General Features
Staging, Grading, & Classification
Gross Pathologic & Surgical Features
Microscopic Features
CLINICAL ISSUES
Presentation
Demographics
Natural History & Prognosis
Treatment
DIAGNOSTIC CHECKLIST
Image Interpretation Pearls
Selected References
- El Kaddouri B et al: Fleischner Society visual emphysema CT patterns help predict progression of emphysema in current and former smokers: results from the COPDGene study. Radiology. 298(2):441-9, 2021
- Martini K et al: Advances in imaging for lung emphysema. Ann Transl Med. 8(21):1467, 2020
- Bhatt SP et al: Imaging advances in chronic obstructive pulmonary disease. insights from the genetic epidemiology of chronic obstructive pulmonary disease (COPDGene) study. Am J Respir Crit Care Med. 199(3):286-301, 2019
- Hochhegger B et al: Pulmonary acinus: understanding the computed tomography findings from an acinar perspective. Lung. 197(3):259-65, 2019
- Lynch DA et al: CT-based visual classification of emphysema: association with mortality in the COPDGene study. Radiology. 288(3):859-66, 2018
- Tanabe N et al: Analysis of airway pathology in COPD using a combination of computed tomography, micro-computed tomography and histology. Eur Respir J. 51(2), 2018
- Tanabe N et al: Micro-computed tomography comparison of preterminal bronchioles in centrilobular and panlobular emphysema. Am J Respir Crit Care Med. 195(5):630-8, 2017
- Corrections. Lancet Respir Med. 4(11):e55, 2016
- Ostridge K et al: Distinct emphysema subtypes defined by quantitative CT analysis are associated with specific pulmonary matrix metalloproteinases. Respir Res. 17(1):92, 2016
- Lynch DA et al: CT-definable subtypes of chronic obstructive pulmonary disease: a statement of the Fleischner Society. Radiology. 277(1):192-205, 2015
- Smith BM et al: Pulmonary emphysema subtypes on computed tomography: the MESA COPD study. Am J Med. 127(1):94.e7-23, 2014
- Gietema HA et al: Quantifying the extent of emphysema: factors associated with radiologists' estimations and quantitative indices of emphysema severity using the ECLIPSE cohort. Acad Radiol. 18(6):661-71, 2011
- Mets OM et al: Identification of chronic obstructive pulmonary disease in lung cancer screening computed tomographic scans. JAMA. 306(16):1775-81, 2011
- Gietema HA et al: Distribution of emphysema in heavy smokers: impact on pulmonary function. Respir Med. 104(1):76-82, 2010
- Sciurba FC et al: A randomized study of endobronchial valves for advanced emphysema. N Engl J Med. 363(13):1233-44, 2010
- Akira M et al: Quantitative CT in chronic obstructive pulmonary disease: inspiratory and expiratory assessment. AJR Am J Roentgenol. 192(1):267-72, 2009
- Litmanovich D et al: CT of pulmonary emphysema--current status, challenges, and future directions. Eur Radiol. 19(3):537-51, 2009
- Ohno Y et al: Oxygen-enhanced magnetic resonance imaging versus computed tomography: multicenter study for clinical stage classification of smoking-related chronic obstructive pulmonary disease. Am J Respir Crit Care Med. 177(10):1095-102, 2008
- Parraga G et al: Hyperpolarized 3He ventilation defects and apparent diffusion coefficients in chronic obstructive pulmonary disease: preliminary results at 3.0 Tesla. Invest Radiol. 42(6):384-91, 2007
- Watz H et al: Micro-CT of the human lung: imaging of alveoli and virtual endoscopy of an alveolar duct in a normal lung and in a lung with centrilobular emphysema--initial observations. Radiology. 236(3):1053-8, 2005
- Bankier AA et al: CT quantification of pulmonary emphysema: assessment of lung structure and function. Crit Rev Comput Tomogr. 43(6):399-417, 2002
- Sugi K et al: The outcome of volume reduction surgery according to the underlying type of emphysema. Surg Today. 31(7):580-5, 2001
- Bankier AA et al: Pulmonary emphysema: subjective visual grading versus objective quantification with macroscopic morphometry and thin-section CT densitometry. Radiology. 211(3):851-8, 1999
- Slone RM et al: Preoperative and postoperative imaging in the surgical management of pulmonary emphysema. Radiol Clin North Am. 36(1):57-89, 1998
- Webb WR: Radiology of obstructive pulmonary disease. AJR Am J Roentgenol. 169(3):637-47, 1997
- Stern EJ et al: CT of the lungs in patients with pulmonary emphysema. Semin Ultrasound CT MR. 16(5):345-52, 1995
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KEY FACTS
Terminology
Imaging
Top Differential Diagnoses
Pathology
Clinical Issues
TERMINOLOGY
Abbreviations
- Centrilobular emphysema (CLE)
Synonyms
- Centriacinar emphysema
- Proximal acinar emphysema
Definitions
- Enlargement and destruction of respiratory bronchioles near center of secondary pulmonary lobule
IMAGING
General Features
Radiographic Findings
CT Findings
Imaging Recommendations
MR Findings
DIFFERENTIAL DIAGNOSIS
PATHOLOGY
General Features
Staging, Grading, & Classification
Gross Pathologic & Surgical Features
Microscopic Features
CLINICAL ISSUES
Presentation
Demographics
Natural History & Prognosis
Treatment
DIAGNOSTIC CHECKLIST
Image Interpretation Pearls
Selected References
- El Kaddouri B et al: Fleischner Society visual emphysema CT patterns help predict progression of emphysema in current and former smokers: results from the COPDGene study. Radiology. 298(2):441-9, 2021
- Martini K et al: Advances in imaging for lung emphysema. Ann Transl Med. 8(21):1467, 2020
- Bhatt SP et al: Imaging advances in chronic obstructive pulmonary disease. insights from the genetic epidemiology of chronic obstructive pulmonary disease (COPDGene) study. Am J Respir Crit Care Med. 199(3):286-301, 2019
- Hochhegger B et al: Pulmonary acinus: understanding the computed tomography findings from an acinar perspective. Lung. 197(3):259-65, 2019
- Lynch DA et al: CT-based visual classification of emphysema: association with mortality in the COPDGene study. Radiology. 288(3):859-66, 2018
- Tanabe N et al: Analysis of airway pathology in COPD using a combination of computed tomography, micro-computed tomography and histology. Eur Respir J. 51(2), 2018
- Tanabe N et al: Micro-computed tomography comparison of preterminal bronchioles in centrilobular and panlobular emphysema. Am J Respir Crit Care Med. 195(5):630-8, 2017
- Corrections. Lancet Respir Med. 4(11):e55, 2016
- Ostridge K et al: Distinct emphysema subtypes defined by quantitative CT analysis are associated with specific pulmonary matrix metalloproteinases. Respir Res. 17(1):92, 2016
- Lynch DA et al: CT-definable subtypes of chronic obstructive pulmonary disease: a statement of the Fleischner Society. Radiology. 277(1):192-205, 2015
- Smith BM et al: Pulmonary emphysema subtypes on computed tomography: the MESA COPD study. Am J Med. 127(1):94.e7-23, 2014
- Gietema HA et al: Quantifying the extent of emphysema: factors associated with radiologists' estimations and quantitative indices of emphysema severity using the ECLIPSE cohort. Acad Radiol. 18(6):661-71, 2011
- Mets OM et al: Identification of chronic obstructive pulmonary disease in lung cancer screening computed tomographic scans. JAMA. 306(16):1775-81, 2011
- Gietema HA et al: Distribution of emphysema in heavy smokers: impact on pulmonary function. Respir Med. 104(1):76-82, 2010
- Sciurba FC et al: A randomized study of endobronchial valves for advanced emphysema. N Engl J Med. 363(13):1233-44, 2010
- Akira M et al: Quantitative CT in chronic obstructive pulmonary disease: inspiratory and expiratory assessment. AJR Am J Roentgenol. 192(1):267-72, 2009
- Litmanovich D et al: CT of pulmonary emphysema--current status, challenges, and future directions. Eur Radiol. 19(3):537-51, 2009
- Ohno Y et al: Oxygen-enhanced magnetic resonance imaging versus computed tomography: multicenter study for clinical stage classification of smoking-related chronic obstructive pulmonary disease. Am J Respir Crit Care Med. 177(10):1095-102, 2008
- Parraga G et al: Hyperpolarized 3He ventilation defects and apparent diffusion coefficients in chronic obstructive pulmonary disease: preliminary results at 3.0 Tesla. Invest Radiol. 42(6):384-91, 2007
- Watz H et al: Micro-CT of the human lung: imaging of alveoli and virtual endoscopy of an alveolar duct in a normal lung and in a lung with centrilobular emphysema--initial observations. Radiology. 236(3):1053-8, 2005
- Bankier AA et al: CT quantification of pulmonary emphysema: assessment of lung structure and function. Crit Rev Comput Tomogr. 43(6):399-417, 2002
- Sugi K et al: The outcome of volume reduction surgery according to the underlying type of emphysema. Surg Today. 31(7):580-5, 2001
- Bankier AA et al: Pulmonary emphysema: subjective visual grading versus objective quantification with macroscopic morphometry and thin-section CT densitometry. Radiology. 211(3):851-8, 1999
- Slone RM et al: Preoperative and postoperative imaging in the surgical management of pulmonary emphysema. Radiol Clin North Am. 36(1):57-89, 1998
- Webb WR: Radiology of obstructive pulmonary disease. AJR Am J Roentgenol. 169(3):637-47, 1997
- Stern EJ et al: CT of the lungs in patients with pulmonary emphysema. Semin Ultrasound CT MR. 16(5):345-52, 1995
