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Centrilobular
Santiago Martínez-Jiménez, MD; Paul P. Pettavel, MD
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KEY FACTS

  • Terminology

    • Imaging

      • Top Differential Diagnoses

        • Pathology

          TERMINOLOGY

          • Synonyms

            • Small airways disease = bronchiolitis
            • Excipient lung disease
              • Cellulose granulomatosis
              • Angiocentric systemic granulomatosis
              • Pulmonary angiothrombotic granulomatosis
              • Pulmonary granulomatous vasculitis
              • Pulmonary foreign body angiogranulomatosis
              • Pulmonary mainline granulomatosis
              • Talc embolism
              • Foreign body microembolism
              • Intravascular talcosis
          • Definitions

            • Diseases that distinctively exhibit micronodules at centers of secondary pulmonary lobules
              • Bronchiolitis (most common)
                • Infectious bronchiolitis
                • Aspiration bronchiolitis
                • Respiratory bronchiolitis (smoking related)
                • Hypersensitivity pneumonitis (allergic)
                • Follicular bronchiolitis (autoimmune disease and chronic immunosuppression)
                • Panbronchiolitis
              • Vascular
                • Excipient lung disease (talc and cellulose granulomatosis)
                • Tumor embolism
              • Other
                • Cholesterol granulomas (related to pulmonary hypertension)
                • Pulmonary capillary hemangiomatosis
            • Micronodule: Discrete round opacity < 3 mm in diameter

          IMAGING

          • General Features

            • Radiographic Findings

              • CT Findings

                • Imaging Recommendations

                  DIFFERENTIAL DIAGNOSIS

                    PATHOLOGY

                    • General Features

                      Selected References

                      1. Frazier AA, Franks TJ, Mohammed TL, Ozbudak IH, Galvin JR. From the Archives of the AFIP: pulmonary veno-occlusive disease and pulmonary capillary hemangiomatosis. Radiographics. May-Jun;27(3):867-82, 2007
                      2. Griffin CB et al: High-resolution CT: normal anatomy, techniques, and pitfalls. Radiol Clin North Am. 39(6):1073-90, v, 2001
                      3. Lee KS et al: Diffuse micronodular lung disease: HRCT and pathologic findings. J Comput Assist Tomogr. 23(1):99-106, 1999
                      4. Colby TV et al: Anatomic distribution and histopathologic patterns in diffuse lung disease: correlation with HRCT. J Thorac Imaging. 11(1):1-26, 1996
                      Related Anatomy
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                      Related Differential Diagnoses
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                      References
                      Tables

                      Tables

                      KEY FACTS

                      • Terminology

                        • Imaging

                          • Top Differential Diagnoses

                            • Pathology

                              TERMINOLOGY

                              • Synonyms

                                • Small airways disease = bronchiolitis
                                • Excipient lung disease
                                  • Cellulose granulomatosis
                                  • Angiocentric systemic granulomatosis
                                  • Pulmonary angiothrombotic granulomatosis
                                  • Pulmonary granulomatous vasculitis
                                  • Pulmonary foreign body angiogranulomatosis
                                  • Pulmonary mainline granulomatosis
                                  • Talc embolism
                                  • Foreign body microembolism
                                  • Intravascular talcosis
                              • Definitions

                                • Diseases that distinctively exhibit micronodules at centers of secondary pulmonary lobules
                                  • Bronchiolitis (most common)
                                    • Infectious bronchiolitis
                                    • Aspiration bronchiolitis
                                    • Respiratory bronchiolitis (smoking related)
                                    • Hypersensitivity pneumonitis (allergic)
                                    • Follicular bronchiolitis (autoimmune disease and chronic immunosuppression)
                                    • Panbronchiolitis
                                  • Vascular
                                    • Excipient lung disease (talc and cellulose granulomatosis)
                                    • Tumor embolism
                                  • Other
                                    • Cholesterol granulomas (related to pulmonary hypertension)
                                    • Pulmonary capillary hemangiomatosis
                                • Micronodule: Discrete round opacity < 3 mm in diameter

                              IMAGING

                              • General Features

                                • Radiographic Findings

                                  • CT Findings

                                    • Imaging Recommendations

                                      DIFFERENTIAL DIAGNOSIS

                                        PATHOLOGY

                                        • General Features

                                          Selected References

                                          1. Frazier AA, Franks TJ, Mohammed TL, Ozbudak IH, Galvin JR. From the Archives of the AFIP: pulmonary veno-occlusive disease and pulmonary capillary hemangiomatosis. Radiographics. May-Jun;27(3):867-82, 2007
                                          2. Griffin CB et al: High-resolution CT: normal anatomy, techniques, and pitfalls. Radiol Clin North Am. 39(6):1073-90, v, 2001
                                          3. Lee KS et al: Diffuse micronodular lung disease: HRCT and pathologic findings. J Comput Assist Tomogr. 23(1):99-106, 1999
                                          4. Colby TV et al: Anatomic distribution and histopathologic patterns in diffuse lung disease: correlation with HRCT. J Thorac Imaging. 11(1):1-26, 1996