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Cerebral Radionecrosis
Christine M. Glastonbury, MBBS
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KEY FACTS

  • Terminology

    • Imaging

      • Top Differential Diagnoses

        • Pathology

          • Clinical Issues

            TERMINOLOGY

            • Synonyms

              • Radiation (XRT) necrosis
            • Definitions

              • Brain parenchymal destruction as late complication of radiation-induced vasculopathy

            IMAGING

            • General Features

              • CT Findings

                • MR Findings

                  • Nuclear Medicine Findings

                    • Imaging Recommendations

                      DIFFERENTIAL DIAGNOSIS

                        PATHOLOGY

                        • General Features

                          • Staging, Grading, & Classification

                            • Gross Pathologic & Surgical Features

                              • Microscopic Features

                                CLINICAL ISSUES

                                • Presentation

                                  • Demographics

                                    • Natural History & Prognosis

                                      • Treatment

                                        DIAGNOSTIC CHECKLIST

                                        • Consider

                                          • Image Interpretation Pearls

                                            • Reporting Tips

                                              Selected References

                                              1. Rane N et al: CNS effects following the treatment of malignancy. Clin Radiol. 67(1):61-8, 2012
                                              2. Chen J et al: Radiation induced temporal lobe necrosis in patients with nasopharyngeal carcinoma: a review of new avenues in its management. Radiat Oncol. 6:128, 2011
                                              3. Dassarath M et al: Temporal lobe necrosis: a dwindling entity in a patient with nasopharyngeal cancer after radiation therapy. Head Neck Oncol. 3:8, 2011
                                              4. Mou YG et al: Surgical management of radiation-induced temporal lobe necrosis in patients with nasopharyngeal carcinoma: report of 14 cases. Head Neck. 33(10):1493-500, 2011
                                              5. Offiah C et al: Post-treatment imaging appearances in head and neck cancer patients. Clin Radiol. 66(1):13-24, 2011
                                              6. Rogers LR et al: Morphologic magnetic resonance imaging features of therapy-induced cerebral necrosis. J Neurooncol. 101(1):25-32, 2011
                                              7. Wang X et al: Successful treatment of radiation-induced temporal lobe necrosis with mouse nerve growth factor. J Clin Oncol. 29(7):e166-8, 2011
                                              8. Carangelo B et al: Therapeutic strategy of late cerebral radionecrosis. A retrospective study of 21 cases. J Neurosurg Sci. 54(1):21-8, 2010
                                              9. Sundgren PC et al: Brain irradiation: effects on normal brain parenchyma and radiation injury. Neuroimaging Clin N Am. 19(4):657-68, 2009
                                              10. Sundgren PC: MR spectroscopy in radiation injury. AJNR Am J Neuroradiol. 30(8):1469-76, 2009
                                              11. Cheng KM et al: Acute hemorrhage in late radiation necrosis of the temporal lobe: report of five cases and review of the literature. J Neurooncol. 51(2):143-50, 2001
                                              Related Anatomy
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                                              Related Differential Diagnoses
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                                              References
                                              Tables

                                              Tables

                                              KEY FACTS

                                              • Terminology

                                                • Imaging

                                                  • Top Differential Diagnoses

                                                    • Pathology

                                                      • Clinical Issues

                                                        TERMINOLOGY

                                                        • Synonyms

                                                          • Radiation (XRT) necrosis
                                                        • Definitions

                                                          • Brain parenchymal destruction as late complication of radiation-induced vasculopathy

                                                        IMAGING

                                                        • General Features

                                                          • CT Findings

                                                            • MR Findings

                                                              • Nuclear Medicine Findings

                                                                • Imaging Recommendations

                                                                  DIFFERENTIAL DIAGNOSIS

                                                                    PATHOLOGY

                                                                    • General Features

                                                                      • Staging, Grading, & Classification

                                                                        • Gross Pathologic & Surgical Features

                                                                          • Microscopic Features

                                                                            CLINICAL ISSUES

                                                                            • Presentation

                                                                              • Demographics

                                                                                • Natural History & Prognosis

                                                                                  • Treatment

                                                                                    DIAGNOSTIC CHECKLIST

                                                                                    • Consider

                                                                                      • Image Interpretation Pearls

                                                                                        • Reporting Tips

                                                                                          Selected References

                                                                                          1. Rane N et al: CNS effects following the treatment of malignancy. Clin Radiol. 67(1):61-8, 2012
                                                                                          2. Chen J et al: Radiation induced temporal lobe necrosis in patients with nasopharyngeal carcinoma: a review of new avenues in its management. Radiat Oncol. 6:128, 2011
                                                                                          3. Dassarath M et al: Temporal lobe necrosis: a dwindling entity in a patient with nasopharyngeal cancer after radiation therapy. Head Neck Oncol. 3:8, 2011
                                                                                          4. Mou YG et al: Surgical management of radiation-induced temporal lobe necrosis in patients with nasopharyngeal carcinoma: report of 14 cases. Head Neck. 33(10):1493-500, 2011
                                                                                          5. Offiah C et al: Post-treatment imaging appearances in head and neck cancer patients. Clin Radiol. 66(1):13-24, 2011
                                                                                          6. Rogers LR et al: Morphologic magnetic resonance imaging features of therapy-induced cerebral necrosis. J Neurooncol. 101(1):25-32, 2011
                                                                                          7. Wang X et al: Successful treatment of radiation-induced temporal lobe necrosis with mouse nerve growth factor. J Clin Oncol. 29(7):e166-8, 2011
                                                                                          8. Carangelo B et al: Therapeutic strategy of late cerebral radionecrosis. A retrospective study of 21 cases. J Neurosurg Sci. 54(1):21-8, 2010
                                                                                          9. Sundgren PC et al: Brain irradiation: effects on normal brain parenchyma and radiation injury. Neuroimaging Clin N Am. 19(4):657-68, 2009
                                                                                          10. Sundgren PC: MR spectroscopy in radiation injury. AJNR Am J Neuroradiol. 30(8):1469-76, 2009
                                                                                          11. Cheng KM et al: Acute hemorrhage in late radiation necrosis of the temporal lobe: report of five cases and review of the literature. J Neurooncol. 51(2):143-50, 2001