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Cervical Melanoma
Akram M. Shaaban, MBBCh; Nyree Griffin, MD, FRCR; Evis Sala, MD, PhD
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KEY FACTS

  • Terminology

    • Imaging

      • Top Differential Diagnoses

        • Pathology

          • Clinical Issues

            TERMINOLOGY

            • Definitions

              • Primary cervical melanoma
                • Can be melanotic or amelanotic

            IMAGING

            • General Features

              • CT Findings

                • MR Findings

                  • Ultrasonographic Findings

                    • Nuclear Medicine Findings

                      • Imaging Recommendations

                        DIFFERENTIAL DIAGNOSIS

                          PATHOLOGY

                          • Staging, Grading, & Classification

                            • Gross Pathologic & Surgical Features

                              • Microscopic Features

                                CLINICAL ISSUES

                                • Presentation

                                  • Demographics

                                    • Natural History & Prognosis

                                      • Treatment

                                        DIAGNOSTIC CHECKLIST

                                        • Consider

                                          • Image Interpretation Pearls

                                            Selected References

                                            1. Calderón-Salazar L et al: Primary malignant melanoma of the uterine cervix treated with ultraradical surgery: a case report. ISRN Obstet Gynecol. 2011:683020, 2011
                                            2. Zhang J et al: A peculiar site: melanoma of the cervix. Am J Obstet Gynecol. 205(5):508, 2011
                                            3. Das P et al: Primary malignant melanoma at unusual sites: an institutional experience with review of literature. Melanoma Res. 20(3):233-9, 2010
                                            4. An J et al: Primary malignant amelanotic melanoma of the female genital tract: report of two cases and review of literature. Melanoma Res. 19(4):267-70, 2009
                                            5. Sugiyama VE et al: Management of melanomas of the female genital tract. Curr Opin Oncol. 20(5):565-9, 2008
                                            6. Jin B et al: Primary melanoma of the uterine cervix after supracervical hysterectomy. A case report. Acta Cytol. 51(1):86-8, 2007
                                            7. Belhocine TZ et al: Role of nuclear medicine in the management of cutaneous malignant melanoma. J Nucl Med. 47(6):957-67, 2006
                                            8. Mousavi AS et al: Primary malignant melanoma of the uterine cervix: case report and review of the literature. J Low Genit Tract Dis. 10(4):258-63, 2006
                                            9. Wydra D et al: Malignant melanoma of the uterine cervix. Eur J Obstet Gynecol Reprod Biol. 124(2):257-8, 2006
                                            10. Gupta R et al: Primary malignant melanoma of cervix - a case report. Indian J Cancer. 42(4):201-4, 2005
                                            11. Ma SQ et al: Clinical analysis of primary malignant melanoma of the cervix. Chin Med Sci J. 20(4):257-60, 2005
                                            12. Siozos C et al: Malignant melanoma of the uterine cervix. J Obstet Gynaecol. 25(8):826-7, 2005
                                            13. Kudrimoti J et al: Primary malignant melanoma of cervix: a case report. Indian J Pathol Microbiol. 47(2):257-8, 2004
                                            14. Saikia UN et al: Melanin containing cells of the uterine cervix and a possible histogenesis--a case report. Indian J Pathol Microbiol. 47(1):22-3, 2004
                                            15. Makovitzky J et al: Primary malignant melanoma of the cervix uteri: a case report of a rare tumor. Anticancer Res. 23(2A):1063-7, 2003
                                            16. Okamoto Y et al: MR imaging of the uterine cervix: imaging-pathologic correlation. Radiographics. 2003
                                            17. Deshpande AH et al: Primary malignant melanoma of the uterine cervix: report of a case diagnosed by cervical scrape cytology and review of the literature. Diagn Cytopathol. 25(2):108-11, 2001
                                            18. Furuya M et al: Clear cell variant of malignant melanoma of the uterine cervix: a case report and review of the literature. Gynecol Oncol. 80(3):409-12, 2001
                                            19. Clark KC et al: Primary malignant melanoma of the uterine cervix: case report with world literature review. Int J Gynecol Pathol. 18(3):265-73, 1999
                                            20. Takehara M et al: Primary malignant melanoma of the uterine cervix: a case report. J Obstet Gynaecol Res. 25(2):129-32, 1999
                                            21. Wasef WR et al: Primary malignant melanoma of the cervix uteri. J Obstet Gynaecol. 19(6):673-4, 1999
                                            22. Teixeira JC et al: Primary melanoma of the uterine cervix figo stage III B. Sao Paulo Med J. 116(4):1778-80, 1998
                                            23. Chang SC et al: Primary malignant melanoma of the vagina and cervix uteri: case report and literature review. Zhonghua Yi Xue Za Zhi (Taipei). 50(4):341-6, 1992
                                            24. Yu HC et al: Detection of malignant melanoma of the uterine cervix from Papanicolaou smears. A case report. Acta Cytol. 31(1):73-6, 1987
                                            Related Anatomy
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                                            Related Differential Diagnoses
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                                            References
                                            Tables

                                            Tables

                                            KEY FACTS

                                            • Terminology

                                              • Imaging

                                                • Top Differential Diagnoses

                                                  • Pathology

                                                    • Clinical Issues

                                                      TERMINOLOGY

                                                      • Definitions

                                                        • Primary cervical melanoma
                                                          • Can be melanotic or amelanotic

                                                      IMAGING

                                                      • General Features

                                                        • CT Findings

                                                          • MR Findings

                                                            • Ultrasonographic Findings

                                                              • Nuclear Medicine Findings

                                                                • Imaging Recommendations

                                                                  DIFFERENTIAL DIAGNOSIS

                                                                    PATHOLOGY

                                                                    • Staging, Grading, & Classification

                                                                      • Gross Pathologic & Surgical Features

                                                                        • Microscopic Features

                                                                          CLINICAL ISSUES

                                                                          • Presentation

                                                                            • Demographics

                                                                              • Natural History & Prognosis

                                                                                • Treatment

                                                                                  DIAGNOSTIC CHECKLIST

                                                                                  • Consider

                                                                                    • Image Interpretation Pearls

                                                                                      Selected References

                                                                                      1. Calderón-Salazar L et al: Primary malignant melanoma of the uterine cervix treated with ultraradical surgery: a case report. ISRN Obstet Gynecol. 2011:683020, 2011
                                                                                      2. Zhang J et al: A peculiar site: melanoma of the cervix. Am J Obstet Gynecol. 205(5):508, 2011
                                                                                      3. Das P et al: Primary malignant melanoma at unusual sites: an institutional experience with review of literature. Melanoma Res. 20(3):233-9, 2010
                                                                                      4. An J et al: Primary malignant amelanotic melanoma of the female genital tract: report of two cases and review of literature. Melanoma Res. 19(4):267-70, 2009
                                                                                      5. Sugiyama VE et al: Management of melanomas of the female genital tract. Curr Opin Oncol. 20(5):565-9, 2008
                                                                                      6. Jin B et al: Primary melanoma of the uterine cervix after supracervical hysterectomy. A case report. Acta Cytol. 51(1):86-8, 2007
                                                                                      7. Belhocine TZ et al: Role of nuclear medicine in the management of cutaneous malignant melanoma. J Nucl Med. 47(6):957-67, 2006
                                                                                      8. Mousavi AS et al: Primary malignant melanoma of the uterine cervix: case report and review of the literature. J Low Genit Tract Dis. 10(4):258-63, 2006
                                                                                      9. Wydra D et al: Malignant melanoma of the uterine cervix. Eur J Obstet Gynecol Reprod Biol. 124(2):257-8, 2006
                                                                                      10. Gupta R et al: Primary malignant melanoma of cervix - a case report. Indian J Cancer. 42(4):201-4, 2005
                                                                                      11. Ma SQ et al: Clinical analysis of primary malignant melanoma of the cervix. Chin Med Sci J. 20(4):257-60, 2005
                                                                                      12. Siozos C et al: Malignant melanoma of the uterine cervix. J Obstet Gynaecol. 25(8):826-7, 2005
                                                                                      13. Kudrimoti J et al: Primary malignant melanoma of cervix: a case report. Indian J Pathol Microbiol. 47(2):257-8, 2004
                                                                                      14. Saikia UN et al: Melanin containing cells of the uterine cervix and a possible histogenesis--a case report. Indian J Pathol Microbiol. 47(1):22-3, 2004
                                                                                      15. Makovitzky J et al: Primary malignant melanoma of the cervix uteri: a case report of a rare tumor. Anticancer Res. 23(2A):1063-7, 2003
                                                                                      16. Okamoto Y et al: MR imaging of the uterine cervix: imaging-pathologic correlation. Radiographics. 2003
                                                                                      17. Deshpande AH et al: Primary malignant melanoma of the uterine cervix: report of a case diagnosed by cervical scrape cytology and review of the literature. Diagn Cytopathol. 25(2):108-11, 2001
                                                                                      18. Furuya M et al: Clear cell variant of malignant melanoma of the uterine cervix: a case report and review of the literature. Gynecol Oncol. 80(3):409-12, 2001
                                                                                      19. Clark KC et al: Primary malignant melanoma of the uterine cervix: case report with world literature review. Int J Gynecol Pathol. 18(3):265-73, 1999
                                                                                      20. Takehara M et al: Primary malignant melanoma of the uterine cervix: a case report. J Obstet Gynaecol Res. 25(2):129-32, 1999
                                                                                      21. Wasef WR et al: Primary malignant melanoma of the cervix uteri. J Obstet Gynaecol. 19(6):673-4, 1999
                                                                                      22. Teixeira JC et al: Primary melanoma of the uterine cervix figo stage III B. Sao Paulo Med J. 116(4):1778-80, 1998
                                                                                      23. Chang SC et al: Primary malignant melanoma of the vagina and cervix uteri: case report and literature review. Zhonghua Yi Xue Za Zhi (Taipei). 50(4):341-6, 1992
                                                                                      24. Yu HC et al: Detection of malignant melanoma of the uterine cervix from Papanicolaou smears. A case report. Acta Cytol. 31(1):73-6, 1987