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Cervical Sarcoma
Douglas Rogers, MD
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KEY FACTS

  • Terminology

    • Imaging

      • Top Differential Diagnoses

        • Pathology

          • Clinical Issues

            • Diagnostic Checklist

              TERMINOLOGY

              • Definitions

                • Mesenchymal tumors arising from cervix

              IMAGING

              • General Features

                • CT Findings

                  • MR Findings

                    • Ultrasonographic Findings

                      • Imaging Recommendations

                        DIFFERENTIAL DIAGNOSIS

                          PATHOLOGY

                          • Gross Pathologic & Surgical Features

                            • Microscopic Features

                              CLINICAL ISSUES

                              • Presentation

                                • Demographics

                                  • Natural History & Prognosis

                                    • Treatment

                                      DIAGNOSTIC CHECKLIST

                                      • Consider

                                        • Image Interpretation Pearls

                                          Selected References

                                          1. Apellaniz-Ruiz M et al: DICER1-associated embryonal rhabdomyosarcoma and adenosarcoma of the gynecologic tract: pathology, molecular genetics, and indications for molecular testing. Genes Chromosomes Cancer. 60(3):217-33, 2021
                                          2. Cheng Y et al: Clinicopathologic and molecular cytogenetic analysis of 8 cases with uterine cervical Ewing sarcoma: case series with literature review. Am J Surg Pathol. 45(4):523-30, 2021
                                          3. Almusalam L et al: Uterine cervix rhabdomyosarcoma: an uncommon entity in an adult patient. BMJ Case Rep. 13(11), 2020
                                          4. Mohapatra D et al: Mullerian adenosarcoma (heterologous) of uterine cervix with sarcomatous overgrowth: a case report with review of the literature. Indian J Pathol Microbiol. 62(1):139-41, 2019
                                          5. Sangiorgio V et al: Fibroblastic malignant peripheral nerve sheath tumour of the uterine cervix: report of a case and literature review with emphasis on possible differential diagnosis. Int J Gynecol Pathol. 37(5):497-503, 2018
                                          6. Kimyon Comert G et al: Therapy modalities, prognostic factors, and outcome of the primary cervical carcinosarcoma: meta-analysis of extremely rare tumor of cervix. Int J Gynecol Cancer. 27(9):1957-69, 2017
                                          7. Kirsch CH et al: Outcome of female pediatric patients diagnosed with genital tract rhabdomyosarcoma based on analysis of cases registered in SEER database between 1973 and 2006. Am J Clin Oncol. 37(1):47-50, 2014
                                          8. Dehner LP et al: Embryonal rhabdomyosarcoma of the uterine cervix: a report of 14 cases and a discussion of its unusual clinicopathological associations. Mod Pathol. 25(4):602-14, 2012
                                          9. Khosla D et al: Sarcomas of uterine cervix: clinicopathological features, treatment, and outcome. Int J Gynecol Cancer. 22(6):1026-30, 2012
                                          10. Qiu LL et al: Sarcomas of abdominal organs: computed tomography and magnetic resonance imaging findings. Semin Ultrasound CT MR. 32(5):405-21, 2011
                                          11. Chiang YC et al: Cervical granulocytic sarcoma: report of one case and review of the literature. Eur J Gynaecol Oncol. 31(6):697-700, 2010
                                          12. Scaravilli G et al: Case report of a sarcoma botryoides of the uterine cervix in fertile age and literature review. Arch Gynecol Obstet. 280(5):863-6, 2009
                                          13. Fadare O: Uncommon sarcomas of the uterine cervix: a review of selected entities. Diagn Pathol. 1:30, 2006
                                          14. Maheshwari A et al: Diagnostic dilemma in a case of malignant mixed mullerian tumor of the cervix. World J Surg Oncol. 4:36, 2006
                                          15. Pathak B et al: Granulocytic sarcoma presenting as tumors of the cervix. Gynecol Oncol. 98(3):493-7, 2005
                                          Related Anatomy
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                                          Related Differential Diagnoses
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                                          References
                                          Tables

                                          Tables

                                          KEY FACTS

                                          • Terminology

                                            • Imaging

                                              • Top Differential Diagnoses

                                                • Pathology

                                                  • Clinical Issues

                                                    • Diagnostic Checklist

                                                      TERMINOLOGY

                                                      • Definitions

                                                        • Mesenchymal tumors arising from cervix

                                                      IMAGING

                                                      • General Features

                                                        • CT Findings

                                                          • MR Findings

                                                            • Ultrasonographic Findings

                                                              • Imaging Recommendations

                                                                DIFFERENTIAL DIAGNOSIS

                                                                  PATHOLOGY

                                                                  • Gross Pathologic & Surgical Features

                                                                    • Microscopic Features

                                                                      CLINICAL ISSUES

                                                                      • Presentation

                                                                        • Demographics

                                                                          • Natural History & Prognosis

                                                                            • Treatment

                                                                              DIAGNOSTIC CHECKLIST

                                                                              • Consider

                                                                                • Image Interpretation Pearls

                                                                                  Selected References

                                                                                  1. Apellaniz-Ruiz M et al: DICER1-associated embryonal rhabdomyosarcoma and adenosarcoma of the gynecologic tract: pathology, molecular genetics, and indications for molecular testing. Genes Chromosomes Cancer. 60(3):217-33, 2021
                                                                                  2. Cheng Y et al: Clinicopathologic and molecular cytogenetic analysis of 8 cases with uterine cervical Ewing sarcoma: case series with literature review. Am J Surg Pathol. 45(4):523-30, 2021
                                                                                  3. Almusalam L et al: Uterine cervix rhabdomyosarcoma: an uncommon entity in an adult patient. BMJ Case Rep. 13(11), 2020
                                                                                  4. Mohapatra D et al: Mullerian adenosarcoma (heterologous) of uterine cervix with sarcomatous overgrowth: a case report with review of the literature. Indian J Pathol Microbiol. 62(1):139-41, 2019
                                                                                  5. Sangiorgio V et al: Fibroblastic malignant peripheral nerve sheath tumour of the uterine cervix: report of a case and literature review with emphasis on possible differential diagnosis. Int J Gynecol Pathol. 37(5):497-503, 2018
                                                                                  6. Kimyon Comert G et al: Therapy modalities, prognostic factors, and outcome of the primary cervical carcinosarcoma: meta-analysis of extremely rare tumor of cervix. Int J Gynecol Cancer. 27(9):1957-69, 2017
                                                                                  7. Kirsch CH et al: Outcome of female pediatric patients diagnosed with genital tract rhabdomyosarcoma based on analysis of cases registered in SEER database between 1973 and 2006. Am J Clin Oncol. 37(1):47-50, 2014
                                                                                  8. Dehner LP et al: Embryonal rhabdomyosarcoma of the uterine cervix: a report of 14 cases and a discussion of its unusual clinicopathological associations. Mod Pathol. 25(4):602-14, 2012
                                                                                  9. Khosla D et al: Sarcomas of uterine cervix: clinicopathological features, treatment, and outcome. Int J Gynecol Cancer. 22(6):1026-30, 2012
                                                                                  10. Qiu LL et al: Sarcomas of abdominal organs: computed tomography and magnetic resonance imaging findings. Semin Ultrasound CT MR. 32(5):405-21, 2011
                                                                                  11. Chiang YC et al: Cervical granulocytic sarcoma: report of one case and review of the literature. Eur J Gynaecol Oncol. 31(6):697-700, 2010
                                                                                  12. Scaravilli G et al: Case report of a sarcoma botryoides of the uterine cervix in fertile age and literature review. Arch Gynecol Obstet. 280(5):863-6, 2009
                                                                                  13. Fadare O: Uncommon sarcomas of the uterine cervix: a review of selected entities. Diagn Pathol. 1:30, 2006
                                                                                  14. Maheshwari A et al: Diagnostic dilemma in a case of malignant mixed mullerian tumor of the cervix. World J Surg Oncol. 4:36, 2006
                                                                                  15. Pathak B et al: Granulocytic sarcoma presenting as tumors of the cervix. Gynecol Oncol. 98(3):493-7, 2005