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CEUS in Treatment Response Evaluation: Chemotherapy
Nathalie Lassau, MD, PhD; Andrej Lyshchik, MD, PhD
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KEY FACTS

  • Systemic Cancer Therapy Response Evaluation

    • DCE-US

      TERMINOLOGY

      • Abbreviations

        • Response evaluation criteria in solid tumors (RECIST)
        • Dynamic contrast-enhanced MR (DCE-MR)
        • Dynamic contrast-enhanced CT (DCE-CT)
        • Dynamic contrast-enhanced US (DCE-US)
        • Area under curve (AUC)

      CLINICAL IMPLICATIONS

      • Antiangiogenic Treatment Response Monitoring

        DCE-US

        • Treatment Response

          • Technique

            • Criteria for Treatment Response Evaluation

              • Limitations

                Selected References

                1. Sidhu PS et al: The EFSUMB guidelines and recommendations for the clinical practice of contrast-enhanced ultrasound (CEUS) in non-hepatic applications: update 2017 (long version). Ultraschall Med. 39(2):e2-e44, 2018
                2. O'Connor JP et al: Imaging biomarker roadmap for cancer studies. Nat Rev Clin Oncol. 14(3):169-186, 2017
                3. Lassau N et al: Selection of an early biomarker for vascular normalization using dynamic contrast-enhanced ultrasonography to predict outcomes of metastatic patients treated with bevacizumab. Ann Oncol. 27(10):1922-8, 2016
                4. Lassau N et al: Validation of dynamic contrast-enhanced ultrasound in predicting outcomes of antiangiogenic therapy for solid tumors: the French multicenter support for innovative and expensive techniques study. Invest Radiol. 49(12):794-800, 2014
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                Tables

                Tables

                KEY FACTS

                • Systemic Cancer Therapy Response Evaluation

                  • DCE-US

                    TERMINOLOGY

                    • Abbreviations

                      • Response evaluation criteria in solid tumors (RECIST)
                      • Dynamic contrast-enhanced MR (DCE-MR)
                      • Dynamic contrast-enhanced CT (DCE-CT)
                      • Dynamic contrast-enhanced US (DCE-US)
                      • Area under curve (AUC)

                    CLINICAL IMPLICATIONS

                    • Antiangiogenic Treatment Response Monitoring

                      DCE-US

                      • Treatment Response

                        • Technique

                          • Criteria for Treatment Response Evaluation

                            • Limitations

                              Selected References

                              1. Sidhu PS et al: The EFSUMB guidelines and recommendations for the clinical practice of contrast-enhanced ultrasound (CEUS) in non-hepatic applications: update 2017 (long version). Ultraschall Med. 39(2):e2-e44, 2018
                              2. O'Connor JP et al: Imaging biomarker roadmap for cancer studies. Nat Rev Clin Oncol. 14(3):169-186, 2017
                              3. Lassau N et al: Selection of an early biomarker for vascular normalization using dynamic contrast-enhanced ultrasonography to predict outcomes of metastatic patients treated with bevacizumab. Ann Oncol. 27(10):1922-8, 2016
                              4. Lassau N et al: Validation of dynamic contrast-enhanced ultrasound in predicting outcomes of antiangiogenic therapy for solid tumors: the French multicenter support for innovative and expensive techniques study. Invest Radiol. 49(12):794-800, 2014