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Ultrasound
Diagnosis
Liver
Focal Solid Masses
CEUS Liver: Tumor Imaging With Sonazoid
CEUS Liver: Tumor Imaging With Sonazoid
Jae Young Lee, MD; Hiroko Iijima, MD; Woo Kyoung Jeong, MD, PhD
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KEY FACTS

  • Technical Considerations

    • Clinical Applications for Liver Diseases

      Technical Considerations

      • Sonazoid

        • Phases of Enhancement

          Clinical Applications for Liver Diseases

          • Diagnosis of Hepatic Lesions

            • Sonazoid CEUS-Guided Interventions

              Selected References

              1. Lee J et al: Focal Nodular hyperplasia of the liver: contrast-enhanced ultrasonographic features with Sonazoid. J Ultrasound Med. 37(6):1473-1480, 2018
              2. Kang TW et al: Added value of contrast-enhanced ultrasound on biopsies of focal hepatic lesions invisible on fusion imaging guidance. Korean J Radiol. 18(1):152-161, 2017
              3. Eso Y et al: Sonazoid-enhanced ultrasonography guidance improves the quality of pathological diagnosis in the biopsy of focal hepatic lesions. Eur J Gastroenterol Hepatol. 28(12):1462-1467, 2016
              4. Inoue T et al: Kupffer phase image of Sonazoid-enhanced US is useful in predicting a hypervascularization of non-hypervascular hypointense hepatic lesions detected on Gd-EOB-DTPA-enhanced MRI: a multicenter retrospective study. J Gastroenterol. 51(2):144-52, 2016
              5. Kumagawa M et al: Contrast-enhanced ultrasonographic findings of serum amyloid A-positive hepatocellular neoplasm: does hepatocellular adenoma arise in cirrhotic liver? World J Hepatol. 8(26):1110-5, 2016
              6. Maruyama H et al: Role of contrast-enhanced ultrasonography with Sonazoid for hepatocellular carcinoma: evidence from a 10-year experience. J Gastroenterol. 51(5):421-33, 2016
              7. Min JH et al: Effect of parenchymal uptake of perfluorobutane microbubbles (Sonazoid(®) ) on radiofrequency ablation of the liver: in vivo experimental study. Liver Int. 36(8):1187-95, 2016
              8. Mishima M et al: Evaluation of contrast Sonazoid-enhanced ultrasonography for the detection of hepatic metastases in breast cancer. Breast Cancer. 23(2):231-41, 2016
              9. Min JH et al: Radiofrequency ablation of very-early-stage hepatocellular carcinoma inconspicuous on fusion imaging with B-mode US: value of fusion imaging with contrast-enhanced US. Clin Mol Hepatol. 20(1):61-70, 2014
              10. Ohama H et al: Images of Sonazoid-enhanced ultrasonography in multistep hepatocarcinogenesis: comparison with Gd-EOB-DTPA-enhanced MRI. J Gastroenterol. 49(6):1081-93, 2014
              11. Sugimoto K et al: Kupffer-phase findings of hepatic hemangiomas in contrast-enhanced ultrasound with sonazoid. Ultrasound Med Biol. 40(6):1089-95, 2014
              12. Claudon M et al: Guidelines and good clinical practice recommendations for contrast enhanced ultrasound (CEUS) in the liver - update 2012: a WFUMB-EFSUMB initiative in cooperation with representatives of AFSUMB, AIUM, ASUM, FLAUS and ICUS. Ultrasound Med Biol. 39(2):187-210, 2013
              13. Barreiros AP et al: Contrast enhanced ultrasound for the diagnosis of hepatocellular carcinoma (HCC): comments on AASLD guidelines. J Hepatol. 57(4):930-2, 2012
              14. Muhi A et al: Diagnosis of colorectal hepatic metastases: comparison of contrast-enhanced CT, contrast-enhanced US, superparamagnetic iron oxide-enhanced MRI, and gadoxetic acid-enhanced MRI. J Magn Reson Imaging. 34(2):326-35, 2011
              15. Nanashima A et al: Usefulness of sonazoid-ultrasonography during hepatectomy in patients with liver tumors: A preliminary study. J Surg Oncol. 103(2):152-7, 2011
              16. Shunichi S et al: Definition of contrast enhancement phases of the liver using a perfluoro-based microbubble agent, perflubutane microbubbles. Ultrasound Med Biol. 35(11):1819-27, 2009
              17. Inoue T et al: Imaging of hepatocellular carcinoma: qualitative and quantitative analysis of postvascular phase contrast-enhanced ultrasonography with sonazoid. Comparison with superparamagnetic iron oxide magnetic resonance images. Oncology. 75 Suppl 1:48-54, 2008
              18. Strobel D et al: Contrast-enhanced ultrasound for the characterization of focal liver lesions--diagnostic accuracy in clinical practice (DEGUM multicenter trial). Ultraschall Med. 29(5):499-505, 2008
              19. Watanabe R et al: Mechanism of hepatic parenchyma-specific contrast of microbubble-based contrast agent for ultrasonography: microscopic studies in rat liver. Invest Radiol. 42(9):643-51, 2007
              20. Yanagisawa K et al: Phagocytosis of ultrasound contrast agent microbubbles by Kupffer cells. Ultrasound Med Biol. 33(2):318-25, 2007
              21. Tanaka M et al: Pathomorphological study of Kupffer cells in hepatocellular carcinoma and hyperplastic nodular lesions in the liver. Hepatology. 24(4):807-12, 1996
              Related Anatomy
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              References
              Tables

              Tables

              KEY FACTS

              • Technical Considerations

                • Clinical Applications for Liver Diseases

                  Technical Considerations

                  • Sonazoid

                    • Phases of Enhancement

                      Clinical Applications for Liver Diseases

                      • Diagnosis of Hepatic Lesions

                        • Sonazoid CEUS-Guided Interventions

                          Selected References

                          1. Lee J et al: Focal Nodular hyperplasia of the liver: contrast-enhanced ultrasonographic features with Sonazoid. J Ultrasound Med. 37(6):1473-1480, 2018
                          2. Kang TW et al: Added value of contrast-enhanced ultrasound on biopsies of focal hepatic lesions invisible on fusion imaging guidance. Korean J Radiol. 18(1):152-161, 2017
                          3. Eso Y et al: Sonazoid-enhanced ultrasonography guidance improves the quality of pathological diagnosis in the biopsy of focal hepatic lesions. Eur J Gastroenterol Hepatol. 28(12):1462-1467, 2016
                          4. Inoue T et al: Kupffer phase image of Sonazoid-enhanced US is useful in predicting a hypervascularization of non-hypervascular hypointense hepatic lesions detected on Gd-EOB-DTPA-enhanced MRI: a multicenter retrospective study. J Gastroenterol. 51(2):144-52, 2016
                          5. Kumagawa M et al: Contrast-enhanced ultrasonographic findings of serum amyloid A-positive hepatocellular neoplasm: does hepatocellular adenoma arise in cirrhotic liver? World J Hepatol. 8(26):1110-5, 2016
                          6. Maruyama H et al: Role of contrast-enhanced ultrasonography with Sonazoid for hepatocellular carcinoma: evidence from a 10-year experience. J Gastroenterol. 51(5):421-33, 2016
                          7. Min JH et al: Effect of parenchymal uptake of perfluorobutane microbubbles (Sonazoid(®) ) on radiofrequency ablation of the liver: in vivo experimental study. Liver Int. 36(8):1187-95, 2016
                          8. Mishima M et al: Evaluation of contrast Sonazoid-enhanced ultrasonography for the detection of hepatic metastases in breast cancer. Breast Cancer. 23(2):231-41, 2016
                          9. Min JH et al: Radiofrequency ablation of very-early-stage hepatocellular carcinoma inconspicuous on fusion imaging with B-mode US: value of fusion imaging with contrast-enhanced US. Clin Mol Hepatol. 20(1):61-70, 2014
                          10. Ohama H et al: Images of Sonazoid-enhanced ultrasonography in multistep hepatocarcinogenesis: comparison with Gd-EOB-DTPA-enhanced MRI. J Gastroenterol. 49(6):1081-93, 2014
                          11. Sugimoto K et al: Kupffer-phase findings of hepatic hemangiomas in contrast-enhanced ultrasound with sonazoid. Ultrasound Med Biol. 40(6):1089-95, 2014
                          12. Claudon M et al: Guidelines and good clinical practice recommendations for contrast enhanced ultrasound (CEUS) in the liver - update 2012: a WFUMB-EFSUMB initiative in cooperation with representatives of AFSUMB, AIUM, ASUM, FLAUS and ICUS. Ultrasound Med Biol. 39(2):187-210, 2013
                          13. Barreiros AP et al: Contrast enhanced ultrasound for the diagnosis of hepatocellular carcinoma (HCC): comments on AASLD guidelines. J Hepatol. 57(4):930-2, 2012
                          14. Muhi A et al: Diagnosis of colorectal hepatic metastases: comparison of contrast-enhanced CT, contrast-enhanced US, superparamagnetic iron oxide-enhanced MRI, and gadoxetic acid-enhanced MRI. J Magn Reson Imaging. 34(2):326-35, 2011
                          15. Nanashima A et al: Usefulness of sonazoid-ultrasonography during hepatectomy in patients with liver tumors: A preliminary study. J Surg Oncol. 103(2):152-7, 2011
                          16. Shunichi S et al: Definition of contrast enhancement phases of the liver using a perfluoro-based microbubble agent, perflubutane microbubbles. Ultrasound Med Biol. 35(11):1819-27, 2009
                          17. Inoue T et al: Imaging of hepatocellular carcinoma: qualitative and quantitative analysis of postvascular phase contrast-enhanced ultrasonography with sonazoid. Comparison with superparamagnetic iron oxide magnetic resonance images. Oncology. 75 Suppl 1:48-54, 2008
                          18. Strobel D et al: Contrast-enhanced ultrasound for the characterization of focal liver lesions--diagnostic accuracy in clinical practice (DEGUM multicenter trial). Ultraschall Med. 29(5):499-505, 2008
                          19. Watanabe R et al: Mechanism of hepatic parenchyma-specific contrast of microbubble-based contrast agent for ultrasonography: microscopic studies in rat liver. Invest Radiol. 42(9):643-51, 2007
                          20. Yanagisawa K et al: Phagocytosis of ultrasound contrast agent microbubbles by Kupffer cells. Ultrasound Med Biol. 33(2):318-25, 2007
                          21. Tanaka M et al: Pathomorphological study of Kupffer cells in hepatocellular carcinoma and hyperplastic nodular lesions in the liver. Hepatology. 24(4):807-12, 1996
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