KEY FACTS
Terminology
Clinical Implications
TERMINOLOGY
Definitions
- Time-intensity curves (TIC) are formed by calculating change in mean signal intensities within defined region of interest (ROI)
- TIC reflects wash-in and washout of contrast agent within manually drawn ROI
- Mean signal intensity within ROI is calculated in linear units, displayed as function of time
- TIC can be generated with logarithmic or linear display and are related by following formula
- Logarithmic value = 10 x log(linear value)
- Linear value = 10^(logarithmic value/10)
- All time and contrast enhancement intensity parameters are calculated using fitted curve and are not derived from raw image data
- Time parameters include
- Time of arrival (TOA): Time from injection of contrast agent to arrival of microbubbles in ROI
- TOA is also referred to as time zero offset (t)
- Wash-in time (WIT): Time interval from TOA to peak enhancement (PE)
- Rise time (RT): Time frame during which intensity varies from 5-95% or 10-90% of PE (or possibly from TOA to PE, depending on software used)
- Wash-out time (WOT): Time from maximum intensity until total washout
- Mean transit time (MTT): Mean time taken for microbubble passage through ROI
- Intensity parameters include
- PE: Maximum intensity of enhancement on TIC, recorded at peak of arterial-phase enhancement and measured in arbitrary intensity units (AIU)
- Combined parameters include
- Area under curve (AUC): Area below time-intensity curve
- AUC is calculated using linear curve and is combined sum of all instant peak enhancement levels on fitted curve
- Wash-in rate (WiR): Tangent of wash-in slope
- Washout rate (WoR): Tangent of washout slope
CLINICAL IMPLICATIONS
Clinical Applications of DCE-US
DCE-US TECHNIQUE
Selected References
- Medellin A et al: Role of contrast-enhanced ultrasound in evaluation of the bowel. Abdom Radiol (NY). 43(4):918-933, 2018
- Wilkens R et al: Persistent enhancement on contrast-enhanced ultrasound studies of severe Crohn's disease: stuck bubbles? Ultrasound Med Biol. 44(11):2189-2198, 2018
- Medellin-Kowalewski A et al: Quantitative contrast-enhanced ultrasound parameters in Crohn disease: their role in disease activity determination with ultrasound. AJR Am J Roentgenol. 206(1):64-73, 2016
- Bolzacchini E. Dynamic contrast-enhanced ultrasonography (DCE-US): current and future applications in Oncology. European Society Rad. 2015
- Fröhlich E et al: Dynamic contrast-enhanced ultrasound for quantification of tissue perfusion. J Ultrasound Med. 34(2):179-96, 2015
- Hudson JM et al: Dynamic contrast enhanced ultrasound for therapy monitoring. Eur J Radiol. 84(9):1650-7, 2015
- Weskott, H. Contrast-Enhanced Ultrasound. Bremen: UNI-MED, 2013
- Zocco MA et al: Early prediction of response to sorafenib in patients with advanced hepatocellular carcinoma: the role of dynamic contrast enhanced ultrasound. J Hepatol. 59(5):1014-21, 2013
- De Franco A et al: Ileal Crohn disease: mural microvascularity quantified with contrast-enhanced US correlates with disease activity. Radiology. 262(2):680-8, 2012
- Dietrich CF et al: An EFSUMB introduction into dynamic contrast-enhanced ultrasound (DCE-US) for quantification of tumour perfusion. Ultraschall Med. 33(4):344-51, 2012
- Gauthier TP et al: Perfusion quantification using dynamic contrast-enhanced ultrasound: the impact of dynamic range and gain on time-intensity curves. Ultrasonics. 51(1):102-6, 2011
- Greis C: Quantitative evaluation of microvascular blood flow by contrast-enhanced ultrasound (CEUS). Clin Hemorheol Microcirc. 49(1-4):137-49, 2011
- Lassau N et al: Dynamic contrast-enhanced ultrasonography (DCE-US) and anti-angiogenic treatments. Discov Med. 11(56):18-24, 2011
- Tang MX et al: Quantitative contrast-enhanced ultrasound imaging: a review of sources of variability. Interface Focus. 1(4):520-39, 2011
- Quaia E et al: The diagnostic value of small bowel wall vascularity after sulfur hexafluoride-filled microbubble injection in patients with Crohn's disease. Correlation with the therapeutic effectiveness of specific anti-inflammatory treatment. Eur J Radiol. 69(3):438-44, 2009
- Medellin-Kowalewski et al: Contrast-enhanced US in Inflammatory Bowel Disease: An Occasional or an Essential Component of Every Exam? Presented at the Radiological Society of North America 2012 Scientific Assembly and Annual Meeting. Chicago, Illinois, 2012
Related Differential Diagnoses
Loading...