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Chagas Disease
Leila Rezai Gharai, MD; John D. Grizzard, MD
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KEY FACTS

  • Terminology

    • Imaging

      • Top Differential Diagnoses

        TERMINOLOGY

        • Synonyms

          • Chagas heart disease, American trypanosomiasis
        • Definitions

          • Infection by protozoan parasite Trypanosoma cruzi transmitted through feces of infected bloodsucking insects in endemic areas of Latin America

        IMAGING

        • General Features

          • Imaging Recommendations

            • Radiographic Findings

              • Echocardiographic Findings

                • MR Findings

                  • CT Findings

                    • Angiographic Findings

                      DIFFERENTIAL DIAGNOSIS

                        PATHOLOGY

                        • General Features

                          • Gross Pathologic & Surgical Features

                            • Microscopic Features

                              CLINICAL ISSUES

                              • Presentation

                                • Demographics

                                  • Natural History & Prognosis

                                    • Treatment

                                      DIAGNOSTIC CHECKLIST

                                      • Consider

                                        • Image Interpretation Pearls

                                          Selected References

                                          1. Noya-Rabelo MM et al: The Presence and Extension of Myocardial Fibrosis in the Undetermined Form of Chagas' Disease: A Study Using Magnetic Resonance. Arq Bras Cardiol. 110(2):124-131, 2018
                                          2. Nunes MCP et al: Multimodality imaging evaluation of Chagas disease: an expert consensus of Brazilian Cardiovascular Imaging Department (DIC) and the European Association of Cardiovascular Imaging (EACVI). Eur Heart J Cardiovasc Imaging. 19(4):459-460n, 2018
                                          3. Uellendahl M et al: Cardiac magnetic resonance-verified myocardial fibrosis in Chagas disease: Clinical correlates and risk stratification. Arq Bras Cardiol. 107(5):460-466, 2016
                                          4. Torreão JA et al: Myocardial tissue characterization in Chagas' heart disease by cardiovascular magnetic resonance. J Cardiovasc Magn Reson. 17:97, 2015
                                          5. Regueiro A et al: Myocardial involvement in Chagas disease: insights from cardiac magnetic resonance. Int J Cardiol. 165(1):107-12, 2013
                                          6. Mello RP et al: Delayed enhancement cardiac magnetic resonance imaging can identify the risk for ventricular tachycardia in chronic Chagas' heart disease. Arq Bras Cardiol. 98(5):421-30, 2012
                                          7. Rassi A Jr et al: Chagas disease. Lancet. 375(9723):1388-402, 2010
                                          8. Rochitte CE et al: Myocardial delayed enhancement by magnetic resonance imaging in patients with Chagas' disease: a marker of disease severity. J Am Coll Cardiol. 46(8):1553-8, 2005
                                          Related Anatomy
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                                          Related Differential Diagnoses
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                                          References
                                          Tables

                                          Tables

                                          KEY FACTS

                                          • Terminology

                                            • Imaging

                                              • Top Differential Diagnoses

                                                TERMINOLOGY

                                                • Synonyms

                                                  • Chagas heart disease, American trypanosomiasis
                                                • Definitions

                                                  • Infection by protozoan parasite Trypanosoma cruzi transmitted through feces of infected bloodsucking insects in endemic areas of Latin America

                                                IMAGING

                                                • General Features

                                                  • Imaging Recommendations

                                                    • Radiographic Findings

                                                      • Echocardiographic Findings

                                                        • MR Findings

                                                          • CT Findings

                                                            • Angiographic Findings

                                                              DIFFERENTIAL DIAGNOSIS

                                                                PATHOLOGY

                                                                • General Features

                                                                  • Gross Pathologic & Surgical Features

                                                                    • Microscopic Features

                                                                      CLINICAL ISSUES

                                                                      • Presentation

                                                                        • Demographics

                                                                          • Natural History & Prognosis

                                                                            • Treatment

                                                                              DIAGNOSTIC CHECKLIST

                                                                              • Consider

                                                                                • Image Interpretation Pearls

                                                                                  Selected References

                                                                                  1. Noya-Rabelo MM et al: The Presence and Extension of Myocardial Fibrosis in the Undetermined Form of Chagas' Disease: A Study Using Magnetic Resonance. Arq Bras Cardiol. 110(2):124-131, 2018
                                                                                  2. Nunes MCP et al: Multimodality imaging evaluation of Chagas disease: an expert consensus of Brazilian Cardiovascular Imaging Department (DIC) and the European Association of Cardiovascular Imaging (EACVI). Eur Heart J Cardiovasc Imaging. 19(4):459-460n, 2018
                                                                                  3. Uellendahl M et al: Cardiac magnetic resonance-verified myocardial fibrosis in Chagas disease: Clinical correlates and risk stratification. Arq Bras Cardiol. 107(5):460-466, 2016
                                                                                  4. Torreão JA et al: Myocardial tissue characterization in Chagas' heart disease by cardiovascular magnetic resonance. J Cardiovasc Magn Reson. 17:97, 2015
                                                                                  5. Regueiro A et al: Myocardial involvement in Chagas disease: insights from cardiac magnetic resonance. Int J Cardiol. 165(1):107-12, 2013
                                                                                  6. Mello RP et al: Delayed enhancement cardiac magnetic resonance imaging can identify the risk for ventricular tachycardia in chronic Chagas' heart disease. Arq Bras Cardiol. 98(5):421-30, 2012
                                                                                  7. Rassi A Jr et al: Chagas disease. Lancet. 375(9723):1388-402, 2010
                                                                                  8. Rochitte CE et al: Myocardial delayed enhancement by magnetic resonance imaging in patients with Chagas' disease: a marker of disease severity. J Am Coll Cardiol. 46(8):1553-8, 2005