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Chemical Proctocolitis
Michael P. Federle, MD, FACR; Mark M. Hammer, BS, MS
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KEY FACTS

  • Terminology

    • Imaging

      • Top Differential Diagnoses

        • Pathology

          • Clinical Issues

            • Diagnostic Checklist

              TERMINOLOGY

              • Synonyms

                • Chemical colitis
                • Glutaraldehyde colitis
                • Postcolonoscopy colitis
              • Definitions

                • Inflammation of colonic mucosa secondary to chemical toxicity
                  • Most commonly colonoscope disinfectant from improperly washed colonoscopes
                • Glutaraldehyde (2%) solution most common disinfectant for endoscopes
                • Hydrogen peroxide also implicated

              IMAGING

              • General Features

                • Imaging Recommendations

                  • CT Findings

                    DIFFERENTIAL DIAGNOSIS

                      PATHOLOGY

                      • General Features

                        • Gross Pathologic & Surgical Features

                          • Microscopic Features

                            CLINICAL ISSUES

                            • Presentation

                              • Natural History & Prognosis

                                DIAGNOSTIC CHECKLIST

                                • Consider

                                  Selected References

                                  1. Ahishali E et al: Chemical Colitis Due to Glutaraldehyde: Case Series and Review of the Literature. Dig Dis Sci. Epub ahead of print, 2008
                                  2. Sheibani S et al: Chemical colitis. J Clin Gastroenterol. 42(2):115-21, 2008
                                  3. Zhang F et al: High concentration glutaraldehyde-induced severe procto-sigmoiditis: treatment experiences and the 20-month follow-up. Dig Liver Dis. 40(6):483-4, 2008
                                  4. Yen HH et al: Glutaraldehyde colitis. Endoscopy. 38 Suppl 2:E98, 2006
                                  5. Stein BL et al: Glutaraldehyde-induced colitis. Can J Surg. 44(2):113-6, 2001
                                  6. Zissin R et al: CT findings of glutaraldehyde colitis: a report of two cases. Clin Radiol. 54(2):123-5, 1999
                                  7. Birnbaum BA et al: Glutaraldehyde colitis: radiologic findings. Radiology. 195(1):131-4, 1995
                                  Related Anatomy
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                                  Related Differential Diagnoses
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                                  References
                                  Tables

                                  Tables

                                  KEY FACTS

                                  • Terminology

                                    • Imaging

                                      • Top Differential Diagnoses

                                        • Pathology

                                          • Clinical Issues

                                            • Diagnostic Checklist

                                              TERMINOLOGY

                                              • Synonyms

                                                • Chemical colitis
                                                • Glutaraldehyde colitis
                                                • Postcolonoscopy colitis
                                              • Definitions

                                                • Inflammation of colonic mucosa secondary to chemical toxicity
                                                  • Most commonly colonoscope disinfectant from improperly washed colonoscopes
                                                • Glutaraldehyde (2%) solution most common disinfectant for endoscopes
                                                • Hydrogen peroxide also implicated

                                              IMAGING

                                              • General Features

                                                • Imaging Recommendations

                                                  • CT Findings

                                                    DIFFERENTIAL DIAGNOSIS

                                                      PATHOLOGY

                                                      • General Features

                                                        • Gross Pathologic & Surgical Features

                                                          • Microscopic Features

                                                            CLINICAL ISSUES

                                                            • Presentation

                                                              • Natural History & Prognosis

                                                                DIAGNOSTIC CHECKLIST

                                                                • Consider

                                                                  Selected References

                                                                  1. Ahishali E et al: Chemical Colitis Due to Glutaraldehyde: Case Series and Review of the Literature. Dig Dis Sci. Epub ahead of print, 2008
                                                                  2. Sheibani S et al: Chemical colitis. J Clin Gastroenterol. 42(2):115-21, 2008
                                                                  3. Zhang F et al: High concentration glutaraldehyde-induced severe procto-sigmoiditis: treatment experiences and the 20-month follow-up. Dig Liver Dis. 40(6):483-4, 2008
                                                                  4. Yen HH et al: Glutaraldehyde colitis. Endoscopy. 38 Suppl 2:E98, 2006
                                                                  5. Stein BL et al: Glutaraldehyde-induced colitis. Can J Surg. 44(2):113-6, 2001
                                                                  6. Zissin R et al: CT findings of glutaraldehyde colitis: a report of two cases. Clin Radiol. 54(2):123-5, 1999
                                                                  7. Birnbaum BA et al: Glutaraldehyde colitis: radiologic findings. Radiology. 195(1):131-4, 1995