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Chemotherapy-Induced Cholangitis
Siva P. Raman, MDMitchell Tublin, MD
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KEY FACTS

  • Terminology

    • Imaging

      • Top Differential Diagnoses

        • Pathology

          TERMINOLOGY

          • Synonyms

            • Chemotherapy-induced sclerosing cholangitis (CISC); biliary sclerosis
          • Definitions

            • Iatrogenic cholangitis following intraarterial chemotherapy for hepatic malignancies or metastases
              • Complication of hepatic artery infusion pump (HAIP) or transarterial chemoembolization (TACE)

          IMAGING

          • General Features

            • Radiographic Findings

              • CT Findings

                • MR Findings

                  • Imaging Recommendations

                    DIFFERENTIAL DIAGNOSIS

                      PATHOLOGY

                      • General Features

                        CLINICAL ISSUES

                        • Presentation

                          • Demographics

                            • Natural History & Prognosis

                              • Treatment

                                DIAGNOSTIC CHECKLIST

                                • Consider

                                  Selected References

                                  1. Kusakabe A et al: Chemotherapy-induced sclerosing cholangitis caused by systemic chemotherapy. ACG Case Rep J. 6(7):e00136, 2019
                                  2. Nguyen KD et al: Atypical causes of cholestasis. World J Gastroenterol. 20(28):9418-26, 2014
                                  3. Ito K et al: Biliary sclerosis after hepatic arterial infusion pump chemotherapy for patients with colorectal cancer liver metastasis: incidence, clinical features, and risk factors. Ann Surg Oncol. 19(5):1609-17, 2012
                                  4. Pua U: Transarterial chemoembolization-induced main duct stricture. Clin Gastroenterol Hepatol. 9(12):A22, 2011
                                  5. Torrisi JM et al: CT findings of chemotherapy-induced toxicity: what radiologists need to know about the clinical and radiologic manifestations of chemotherapy toxicity. Radiology. 258(1):41-56, 2011
                                  6. Kato Y et al: Chemotherapy-induced sclerosing cholangitis as a rare indication for resection: report of a case. Surg Today. 39(10):905-8, 2009
                                  7. Bang BW et al: Ischemic biliary stricture developed after repeated transcatheter arterial chemoembolization diagnosed by percutaneous transhepatic cholangioscopy in a patient with hepatocellular carcinoma. Gastrointest Endosc. 68(6):1224-6, 2008
                                  8. Menias CO et al: Mimics of cholangiocarcinoma: spectrum of disease. Radiographics. 28(4):1115-29, 2008
                                  9. Alazmi WM et al: Chemotherapy-induced sclerosing cholangitis: long-term response to endoscopic therapy. J Clin Gastroenterol. 40(4):353-7, 2006
                                  10. Sandrasegaran K et al: Chemotherapy-induced sclerosing cholangitis. Clin Radiol. 61(8):670-8, 2006
                                  11. Phongkitkarun S et al: Bile duct complications of hepatic arterial infusion chemotherapy evaluated by helical CT. Clin Radiol. 60(6):700-9, 2005
                                  12. Aldrighetti L et al: Extrahepatic biliary stenoses after hepatic arterial infusion (HAI) of floxuridine (FUdR) for liver metastases from colorectal cancer. Hepatogastroenterology. 48(41):1302-7, 2001
                                  13. Tarazov PG et al: Ischemic complications of transcatheter arterial chemoembolization in liver malignancies. Acta Radiol. 41(2):156-60, 2000
                                  14. Pozniak MA et al: Complications of hepatic arterial infusion chemotherapy. Radiographics. 11(1):67-79, 1991
                                  15. Shea WJ Jr et al: Sclerosing cholangitis associated with hepatic arterial FUDR chemotherapy: radiographic-histologic correlation. AJR Am J Roentgenol. 146(4):717-21, 1986
                                  16. Botet JF et al: Cholangitis complicating intraarterial chemotherapy in liver metastasis. Radiology. 156(2):335-7, 1985
                                  Related Anatomy
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                                  Related Differential Diagnoses
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                                  References
                                  Tables

                                  Tables

                                  KEY FACTS

                                  • Terminology

                                    • Imaging

                                      • Top Differential Diagnoses

                                        • Pathology

                                          TERMINOLOGY

                                          • Synonyms

                                            • Chemotherapy-induced sclerosing cholangitis (CISC); biliary sclerosis
                                          • Definitions

                                            • Iatrogenic cholangitis following intraarterial chemotherapy for hepatic malignancies or metastases
                                              • Complication of hepatic artery infusion pump (HAIP) or transarterial chemoembolization (TACE)

                                          IMAGING

                                          • General Features

                                            • Radiographic Findings

                                              • CT Findings

                                                • MR Findings

                                                  • Imaging Recommendations

                                                    DIFFERENTIAL DIAGNOSIS

                                                      PATHOLOGY

                                                      • General Features

                                                        CLINICAL ISSUES

                                                        • Presentation

                                                          • Demographics

                                                            • Natural History & Prognosis

                                                              • Treatment

                                                                DIAGNOSTIC CHECKLIST

                                                                • Consider

                                                                  Selected References

                                                                  1. Kusakabe A et al: Chemotherapy-induced sclerosing cholangitis caused by systemic chemotherapy. ACG Case Rep J. 6(7):e00136, 2019
                                                                  2. Nguyen KD et al: Atypical causes of cholestasis. World J Gastroenterol. 20(28):9418-26, 2014
                                                                  3. Ito K et al: Biliary sclerosis after hepatic arterial infusion pump chemotherapy for patients with colorectal cancer liver metastasis: incidence, clinical features, and risk factors. Ann Surg Oncol. 19(5):1609-17, 2012
                                                                  4. Pua U: Transarterial chemoembolization-induced main duct stricture. Clin Gastroenterol Hepatol. 9(12):A22, 2011
                                                                  5. Torrisi JM et al: CT findings of chemotherapy-induced toxicity: what radiologists need to know about the clinical and radiologic manifestations of chemotherapy toxicity. Radiology. 258(1):41-56, 2011
                                                                  6. Kato Y et al: Chemotherapy-induced sclerosing cholangitis as a rare indication for resection: report of a case. Surg Today. 39(10):905-8, 2009
                                                                  7. Bang BW et al: Ischemic biliary stricture developed after repeated transcatheter arterial chemoembolization diagnosed by percutaneous transhepatic cholangioscopy in a patient with hepatocellular carcinoma. Gastrointest Endosc. 68(6):1224-6, 2008
                                                                  8. Menias CO et al: Mimics of cholangiocarcinoma: spectrum of disease. Radiographics. 28(4):1115-29, 2008
                                                                  9. Alazmi WM et al: Chemotherapy-induced sclerosing cholangitis: long-term response to endoscopic therapy. J Clin Gastroenterol. 40(4):353-7, 2006
                                                                  10. Sandrasegaran K et al: Chemotherapy-induced sclerosing cholangitis. Clin Radiol. 61(8):670-8, 2006
                                                                  11. Phongkitkarun S et al: Bile duct complications of hepatic arterial infusion chemotherapy evaluated by helical CT. Clin Radiol. 60(6):700-9, 2005
                                                                  12. Aldrighetti L et al: Extrahepatic biliary stenoses after hepatic arterial infusion (HAI) of floxuridine (FUdR) for liver metastases from colorectal cancer. Hepatogastroenterology. 48(41):1302-7, 2001
                                                                  13. Tarazov PG et al: Ischemic complications of transcatheter arterial chemoembolization in liver malignancies. Acta Radiol. 41(2):156-60, 2000
                                                                  14. Pozniak MA et al: Complications of hepatic arterial infusion chemotherapy. Radiographics. 11(1):67-79, 1991
                                                                  15. Shea WJ Jr et al: Sclerosing cholangitis associated with hepatic arterial FUDR chemotherapy: radiographic-histologic correlation. AJR Am J Roentgenol. 146(4):717-21, 1986
                                                                  16. Botet JF et al: Cholangitis complicating intraarterial chemotherapy in liver metastasis. Radiology. 156(2):335-7, 1985