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Cholangiocarcinoma
R. Brooke Jeffrey, MD; Amir A. Borhani, MD
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17

KEY FACTS

  • Imaging

    • Top Differential Diagnoses

      • Pathology

        TERMINOLOGY

        • Abbreviations

          • Cholangiocarcinoma (CCa)
        • Synonyms

          • Cholangiocellular or bile duct adenocarcinoma
        • Definitions

          • Malignancy arising from intrahepatic bile duct (IHBD) or extrahepatic bile duct epithelium

        IMAGING

        • General Features

          • Radiographic Findings

            • CT Findings

              • MR Findings

                • Ultrasonographic Findings

                  • Angiographic Findings

                    • Nuclear Medicine Findings

                      • Imaging Recommendations

                        DIFFERENTIAL DIAGNOSIS

                          PATHOLOGY

                          • General Features

                            • Staging, Grading, & Classification

                              • Gross Pathologic & Surgical Features

                                • Microscopic Features

                                  CLINICAL ISSUES

                                  • Presentation

                                    • Demographics

                                      • Natural History & Prognosis

                                        • Treatment

                                          DIAGNOSTIC CHECKLIST

                                          • Consider

                                            • Image Interpretation Pearls

                                              Selected References

                                              1. Kim SA et al: Intrahepatic mass-forming cholangiocarcinomas: enhancement patterns at multiphasic CT, with special emphasis on arterial enhancement pattern--correlation with clinicopathologic findings. Radiology. 260(1):148-57, 2011
                                              2. Choi JY et al: Hilar cholangiocarcinoma: role of preoperative imaging with sonography, MDCT, MRI, and direct cholangiography. AJR Am J Roentgenol. 191(5):1448-57, 2008
                                              3. Menias CO et al: Mimics of cholangiocarcinoma: spectrum of disease. Radiographics. 28(4):1115-29, 2008
                                              4. Park HS et al: Preoperative evaluation of bile duct cancer: MRI combined with MR cholangiopancreatography versus MDCT with direct cholangiography. AJR Am J Roentgenol. 190(2):396-405, 2008
                                              5. Kim YH: Extrahepatic cholangiocarcinoma associated with clonorchiasis: CT evaluation. Abdom Imaging. 28(1):68-71, 2003
                                              6. Han JK et al: Cholangiocarcinoma: pictorial essay of CT and cholangiographic findings. Radiographics. 22(1):173-87, 2002
                                              7. Campbell WL et al: Using CT and cholangiography to diagnose biliary tract carcinoma complicating primary sclerosing cholangitis. AJR Am J Roentgenol. 177(5):1095-100, 2001
                                              8. Lee WJ et al: Radiologic spectrum of cholangiocarcinoma: emphasis on unusual manifestations and differential diagnoses. Radiographics. 21 Spec No:S97-S116, 2001
                                              9. Maetani Y et al: MR imaging of intrahepatic cholangiocarcinoma with pathologic correlation. AJR Am J Roentgenol. 176(6):1499-507, 2001
                                              10. Han JK et al: Hilar cholangiocarcinoma: thin-section spiral CT findings with cholangiographic correlation. Radiographics. 17(6):1475-85, 1997
                                              Related Anatomy
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                                              Related Differential Diagnoses
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                                              References
                                              Tables

                                              Tables

                                              KEY FACTS

                                              • Imaging

                                                • Top Differential Diagnoses

                                                  • Pathology

                                                    TERMINOLOGY

                                                    • Abbreviations

                                                      • Cholangiocarcinoma (CCa)
                                                    • Synonyms

                                                      • Cholangiocellular or bile duct adenocarcinoma
                                                    • Definitions

                                                      • Malignancy arising from intrahepatic bile duct (IHBD) or extrahepatic bile duct epithelium

                                                    IMAGING

                                                    • General Features

                                                      • Radiographic Findings

                                                        • CT Findings

                                                          • MR Findings

                                                            • Ultrasonographic Findings

                                                              • Angiographic Findings

                                                                • Nuclear Medicine Findings

                                                                  • Imaging Recommendations

                                                                    DIFFERENTIAL DIAGNOSIS

                                                                      PATHOLOGY

                                                                      • General Features

                                                                        • Staging, Grading, & Classification

                                                                          • Gross Pathologic & Surgical Features

                                                                            • Microscopic Features

                                                                              CLINICAL ISSUES

                                                                              • Presentation

                                                                                • Demographics

                                                                                  • Natural History & Prognosis

                                                                                    • Treatment

                                                                                      DIAGNOSTIC CHECKLIST

                                                                                      • Consider

                                                                                        • Image Interpretation Pearls

                                                                                          Selected References

                                                                                          1. Kim SA et al: Intrahepatic mass-forming cholangiocarcinomas: enhancement patterns at multiphasic CT, with special emphasis on arterial enhancement pattern--correlation with clinicopathologic findings. Radiology. 260(1):148-57, 2011
                                                                                          2. Choi JY et al: Hilar cholangiocarcinoma: role of preoperative imaging with sonography, MDCT, MRI, and direct cholangiography. AJR Am J Roentgenol. 191(5):1448-57, 2008
                                                                                          3. Menias CO et al: Mimics of cholangiocarcinoma: spectrum of disease. Radiographics. 28(4):1115-29, 2008
                                                                                          4. Park HS et al: Preoperative evaluation of bile duct cancer: MRI combined with MR cholangiopancreatography versus MDCT with direct cholangiography. AJR Am J Roentgenol. 190(2):396-405, 2008
                                                                                          5. Kim YH: Extrahepatic cholangiocarcinoma associated with clonorchiasis: CT evaluation. Abdom Imaging. 28(1):68-71, 2003
                                                                                          6. Han JK et al: Cholangiocarcinoma: pictorial essay of CT and cholangiographic findings. Radiographics. 22(1):173-87, 2002
                                                                                          7. Campbell WL et al: Using CT and cholangiography to diagnose biliary tract carcinoma complicating primary sclerosing cholangitis. AJR Am J Roentgenol. 177(5):1095-100, 2001
                                                                                          8. Lee WJ et al: Radiologic spectrum of cholangiocarcinoma: emphasis on unusual manifestations and differential diagnoses. Radiographics. 21 Spec No:S97-S116, 2001
                                                                                          9. Maetani Y et al: MR imaging of intrahepatic cholangiocarcinoma with pathologic correlation. AJR Am J Roentgenol. 176(6):1499-507, 2001
                                                                                          10. Han JK et al: Hilar cholangiocarcinoma: thin-section spiral CT findings with cholangiographic correlation. Radiographics. 17(6):1475-85, 1997