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Cholangiocarcinoma
David Burrowes, MD; Aya Kamaya, MD, FSRU, FSAR
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KEY FACTS

  • Terminology

    • Imaging

      • Top Differential Diagnoses

        • Pathology

          • Diagnostic Checklist

            TERMINOLOGY

            • Abbreviations

              • Cholangiocarcinoma (CCA), intrahepatic cholangiocarcinoma (ICC, ICCA)
            • Synonyms

              • Cholangiocellular carcinoma or bile duct adenocarcinoma
            • Definitions

              • Malignancy that arises from intrahepatic bile duct (IHBD) or extrahepatic bile duct epithelium

            IMAGING

            • General Features

              • Ultrasonographic Findings

                • Radiographic Findings

                  • CT Findings

                    • MR Findings

                      • Imaging Recommendations

                        DIFFERENTIAL DIAGNOSIS

                          PATHOLOGY

                          • General Features

                            • Gross Pathologic & Surgical Features

                              • Microscopic Features

                                CLINICAL ISSUES

                                • Presentation

                                  • Demographics

                                    • Natural History & Prognosis

                                      • Treatment

                                        DIAGNOSTIC CHECKLIST

                                        • Consider

                                          • Image Interpretation Pearls

                                            Selected References

                                            1. Burrowes DP et al: Characterization of focal liver masses: a multicenter comparison of contrast-enhanced ultrasound, computed tomography, and magnetic resonance imaging. J Ultrasound Med. ePub, 2021
                                            2. Banales JM et al: Cholangiocarcinoma 2020: the next horizon in mechanisms and management. Nat Rev Gastroenterol Hepatol. 17(9):557-88, 2020
                                            3. Burrowes DP et al: RadioGraphics update: contrast-enhanced US approach to the diagnosis of focal liver masses. Radiographics. 40(4):E16-20, 2020
                                            4. Huang JY et al: Can contrast enhanced ultrasound differentiate intrahepatic cholangiocarcinoma from hepatocellular carcinoma? World J Gastroenterol. 26(27):3938-51, 2020
                                            5. Durot I et al: Contrast-enhanced ultrasound of malignant liver lesions. Abdom Radiol (NY). 43(4):819-47, 2018
                                            6. Lee AJ et al: Intrahepatic cholangiocarcinoma: the AJCC/UICC 8th edition updates. Chin Clin Oncol. 7(5):52, 2018
                                            7. Burrowes DP et al: Contrast-enhanced US approach to the diagnosis of focal liver masses. Radiographics. 37(5):1388-400, 2017
                                            8. Chung YE et al: Varying appearances of cholangiocarcinoma: radiologic-pathologic correlation. Radiographics. 29(3):683-700, 2009
                                            9. Vilgrain V: Staging cholangiocarcinoma by imaging studies. HPB (Oxford). 10(2):106-9, 2008
                                            10. Han JK et al: Cholangiocarcinoma: pictorial essay of CT and cholangiographic findings. Radiographics. 22(1):173-87, 2002
                                            11. Lee WJ et al: Radiologic spectrum of cholangiocarcinoma: emphasis on unusual manifestations and differential diagnoses. Radiographics. 21 Spec No:S97-S116, 2001
                                            Related Anatomy
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                                            Related Differential Diagnoses
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                                            References
                                            Tables

                                            Tables

                                            KEY FACTS

                                            • Terminology

                                              • Imaging

                                                • Top Differential Diagnoses

                                                  • Pathology

                                                    • Diagnostic Checklist

                                                      TERMINOLOGY

                                                      • Abbreviations

                                                        • Cholangiocarcinoma (CCA), intrahepatic cholangiocarcinoma (ICC, ICCA)
                                                      • Synonyms

                                                        • Cholangiocellular carcinoma or bile duct adenocarcinoma
                                                      • Definitions

                                                        • Malignancy that arises from intrahepatic bile duct (IHBD) or extrahepatic bile duct epithelium

                                                      IMAGING

                                                      • General Features

                                                        • Ultrasonographic Findings

                                                          • Radiographic Findings

                                                            • CT Findings

                                                              • MR Findings

                                                                • Imaging Recommendations

                                                                  DIFFERENTIAL DIAGNOSIS

                                                                    PATHOLOGY

                                                                    • General Features

                                                                      • Gross Pathologic & Surgical Features

                                                                        • Microscopic Features

                                                                          CLINICAL ISSUES

                                                                          • Presentation

                                                                            • Demographics

                                                                              • Natural History & Prognosis

                                                                                • Treatment

                                                                                  DIAGNOSTIC CHECKLIST

                                                                                  • Consider

                                                                                    • Image Interpretation Pearls

                                                                                      Selected References

                                                                                      1. Burrowes DP et al: Characterization of focal liver masses: a multicenter comparison of contrast-enhanced ultrasound, computed tomography, and magnetic resonance imaging. J Ultrasound Med. ePub, 2021
                                                                                      2. Banales JM et al: Cholangiocarcinoma 2020: the next horizon in mechanisms and management. Nat Rev Gastroenterol Hepatol. 17(9):557-88, 2020
                                                                                      3. Burrowes DP et al: RadioGraphics update: contrast-enhanced US approach to the diagnosis of focal liver masses. Radiographics. 40(4):E16-20, 2020
                                                                                      4. Huang JY et al: Can contrast enhanced ultrasound differentiate intrahepatic cholangiocarcinoma from hepatocellular carcinoma? World J Gastroenterol. 26(27):3938-51, 2020
                                                                                      5. Durot I et al: Contrast-enhanced ultrasound of malignant liver lesions. Abdom Radiol (NY). 43(4):819-47, 2018
                                                                                      6. Lee AJ et al: Intrahepatic cholangiocarcinoma: the AJCC/UICC 8th edition updates. Chin Clin Oncol. 7(5):52, 2018
                                                                                      7. Burrowes DP et al: Contrast-enhanced US approach to the diagnosis of focal liver masses. Radiographics. 37(5):1388-400, 2017
                                                                                      8. Chung YE et al: Varying appearances of cholangiocarcinoma: radiologic-pathologic correlation. Radiographics. 29(3):683-700, 2009
                                                                                      9. Vilgrain V: Staging cholangiocarcinoma by imaging studies. HPB (Oxford). 10(2):106-9, 2008
                                                                                      10. Han JK et al: Cholangiocarcinoma: pictorial essay of CT and cholangiographic findings. Radiographics. 22(1):173-87, 2002
                                                                                      11. Lee WJ et al: Radiologic spectrum of cholangiocarcinoma: emphasis on unusual manifestations and differential diagnoses. Radiographics. 21 Spec No:S97-S116, 2001