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Chondrosarcoma, Craniovertebral Junction
Cheryl A. Petersilge, MD, MBA
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KEY FACTS

  • Terminology

    • Imaging

      • Top Differential Diagnoses

        • Clinical Issues

          TERMINOLOGY

          • Abbreviations

            • Chondrosarcoma (CHS)
          • Definitions

            • Malignant tumor of connective tissue, characterized by formation of cartilage matrix by tumor cells

          IMAGING

          • General Features

            • Radiographic Findings

              • CT Findings

                • MR Findings

                  • Nuclear Medicine Findings

                    • Imaging Recommendations

                      DIFFERENTIAL DIAGNOSIS

                        PATHOLOGY

                        • General Features

                          • Staging, Grading, & Classification

                            • Gross Pathologic & Surgical Features

                              • Microscopic Features

                                • Histologic Subtypes

                                  CLINICAL ISSUES

                                  • Presentation

                                    • Demographics

                                      • Natural History & Prognosis

                                        • Treatment

                                          DIAGNOSTIC CHECKLIST

                                          • Consider

                                            Selected References

                                            1. Yang X et al: Chondrosarcomas of the cervical and cervicothoracic spine: surgical management and long-term clinical outcome. J Spinal Disord Tech. 25(1):1-9, 2012
                                            2. Boriani S et al: Challenges of local recurrence and cure in low grade malignant tumors of the spine. Spine (Phila Pa 1976). 34(22 Suppl):S48-57, 2009
                                            3. Hong P et al: Chondrosarcoma of the head and neck: report of 11 cases and literature review. J Otolaryngol Head Neck Surg. 38(2):279-85, 2009
                                            4. McLoughlin GS et al: Chondroma/Chondrosarcoma of the spine. Neurosurg Clin N Am. 19(1):57-63, 2008
                                            5. Rao G et al: Surgical management of primary and metastatic sarcoma of the mobile spine. J Neurosurg Spine. 9(2):120-8, 2008
                                            6. Lloret I et al: Primary spinal chondrosarcoma: radiologic findings with pathologic correlation. Acta Radiol. 47(1):77-84, 2006
                                            7. Murphey MD et al: From the archives of the AFIP: imaging of primary chondrosarcoma: radiologic-pathologic correlation. Radiographics. 23(5):1245-78, 2003
                                            8. Boriani S et al: Chondrosarcoma of the mobile spine: report on 22 cases. Spine (Phila Pa 1976). 25(7):804-12, 2000
                                            9. Rosenberg AE et al: Chondrosarcoma of the base of the skull: a clinicopathologic study of 200 cases with emphasis on its distinction from chordoma. Am J Surg Pathol. 23(11):1370-8, 1999
                                            10. Björnsson J et al: Primary chondrosarcoma of long bones and limb girdles. Cancer. 83(10):2105-19, 1998
                                            11. Dorfman HD et al: Bone tumors. 1st ed. St. Louis: Mosby. 353-440, 1998
                                            12. Greenspan A et al: Differential Diagnosis of Tumors and Tumor-Like Lesions of Bones and Joints. 1st ed. Philadelphia: Lippincott-Raven. 169-98, 1998
                                            13. Leis AA et al: Chondrosarcoma of the spine and thyroid carcinoma following radiation therapy for Hodgkin's lymphoma. Neurology. 48(6):1710-2, 1997
                                            14. Swarts SJ et al: Chromosomal abnormalities in low grade chondrosarcoma and a review of the literature. Cancer Genet Cytogenet. 98(2):126-30, 1997
                                            15. Mercuri M et al: Dedifferentiated chondrosarcoma. Skeletal Radiol. 24(6):409-16, 1995
                                            16. Aoki J et al: MR of enchondroma and chondrosarcoma: rings and arcs of Gd-DTPA enhancement. J Comput Assist Tomogr. 15(6):1011-6, 1991
                                            Related Anatomy
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                                            Related Differential Diagnoses
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                                            References
                                            Tables

                                            Tables

                                            KEY FACTS

                                            • Terminology

                                              • Imaging

                                                • Top Differential Diagnoses

                                                  • Clinical Issues

                                                    TERMINOLOGY

                                                    • Abbreviations

                                                      • Chondrosarcoma (CHS)
                                                    • Definitions

                                                      • Malignant tumor of connective tissue, characterized by formation of cartilage matrix by tumor cells

                                                    IMAGING

                                                    • General Features

                                                      • Radiographic Findings

                                                        • CT Findings

                                                          • MR Findings

                                                            • Nuclear Medicine Findings

                                                              • Imaging Recommendations

                                                                DIFFERENTIAL DIAGNOSIS

                                                                  PATHOLOGY

                                                                  • General Features

                                                                    • Staging, Grading, & Classification

                                                                      • Gross Pathologic & Surgical Features

                                                                        • Microscopic Features

                                                                          • Histologic Subtypes

                                                                            CLINICAL ISSUES

                                                                            • Presentation

                                                                              • Demographics

                                                                                • Natural History & Prognosis

                                                                                  • Treatment

                                                                                    DIAGNOSTIC CHECKLIST

                                                                                    • Consider

                                                                                      Selected References

                                                                                      1. Yang X et al: Chondrosarcomas of the cervical and cervicothoracic spine: surgical management and long-term clinical outcome. J Spinal Disord Tech. 25(1):1-9, 2012
                                                                                      2. Boriani S et al: Challenges of local recurrence and cure in low grade malignant tumors of the spine. Spine (Phila Pa 1976). 34(22 Suppl):S48-57, 2009
                                                                                      3. Hong P et al: Chondrosarcoma of the head and neck: report of 11 cases and literature review. J Otolaryngol Head Neck Surg. 38(2):279-85, 2009
                                                                                      4. McLoughlin GS et al: Chondroma/Chondrosarcoma of the spine. Neurosurg Clin N Am. 19(1):57-63, 2008
                                                                                      5. Rao G et al: Surgical management of primary and metastatic sarcoma of the mobile spine. J Neurosurg Spine. 9(2):120-8, 2008
                                                                                      6. Lloret I et al: Primary spinal chondrosarcoma: radiologic findings with pathologic correlation. Acta Radiol. 47(1):77-84, 2006
                                                                                      7. Murphey MD et al: From the archives of the AFIP: imaging of primary chondrosarcoma: radiologic-pathologic correlation. Radiographics. 23(5):1245-78, 2003
                                                                                      8. Boriani S et al: Chondrosarcoma of the mobile spine: report on 22 cases. Spine (Phila Pa 1976). 25(7):804-12, 2000
                                                                                      9. Rosenberg AE et al: Chondrosarcoma of the base of the skull: a clinicopathologic study of 200 cases with emphasis on its distinction from chordoma. Am J Surg Pathol. 23(11):1370-8, 1999
                                                                                      10. Björnsson J et al: Primary chondrosarcoma of long bones and limb girdles. Cancer. 83(10):2105-19, 1998
                                                                                      11. Dorfman HD et al: Bone tumors. 1st ed. St. Louis: Mosby. 353-440, 1998
                                                                                      12. Greenspan A et al: Differential Diagnosis of Tumors and Tumor-Like Lesions of Bones and Joints. 1st ed. Philadelphia: Lippincott-Raven. 169-98, 1998
                                                                                      13. Leis AA et al: Chondrosarcoma of the spine and thyroid carcinoma following radiation therapy for Hodgkin's lymphoma. Neurology. 48(6):1710-2, 1997
                                                                                      14. Swarts SJ et al: Chromosomal abnormalities in low grade chondrosarcoma and a review of the literature. Cancer Genet Cytogenet. 98(2):126-30, 1997
                                                                                      15. Mercuri M et al: Dedifferentiated chondrosarcoma. Skeletal Radiol. 24(6):409-16, 1995
                                                                                      16. Aoki J et al: MR of enchondroma and chondrosarcoma: rings and arcs of Gd-DTPA enhancement. J Comput Assist Tomogr. 15(6):1011-6, 1991