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Chondrosarcoma
Nathaniel Garrett Gray, MD; Paige Bennett, MD
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KEY FACTS

  • Terminology

    • Imaging

      • Top Differential Diagnoses

        • Pathology

          • Clinical Issues

            TERMINOLOGY

            • Definitions

              • Chondrosarcoma: Malignant cartilaginous tumor
                • Primary: Arise from normal bone
                  • 3rd most common primary bone tumor
                • Secondary: Arise from preexisting lesions (e.g., enchondroma, osteochondroma)
              • Primary chondrosarcoma subtypes
                • Intramedullary (most common)
                • Clear cell
                • Juxtacortical
                • Myxoid
                • Mesenchymal
                • Extraskeletal
                • Dedifferentiated
              • Location
                • Most chondrosarcomas occur in long bones (45%)
                  • Typically metaphyseal or metadiaphyseal
                • Pelvis (25%)
                • Less common locations: Ribs, spine, scapula, sternum, head & neck, craniofacial

            IMAGING

            • F-18 FDG PET/CT Findings

              • Radiography Findings

                • CT Findings

                  • MR Findings

                    • Nuclear Medicine

                      • Imaging Recommendations

                        DIFFERENTIAL DIAGNOSIS

                          PATHOLOGY

                          • General Features

                            • Staging, Grading, & Classification

                              CLINICAL ISSUES

                              • Presentation

                                • Demographics

                                  • Natural History & Prognosis

                                    • Treatment

                                      Selected References

                                      1. Jesus-Garcia R et al: Is PET-CT an accurate method for the differential diagnosis between chondroma and chondrosarcoma? Springerplus. 5:236, 2016
                                      2. Murphey MD et al. Imaging of primary chondrosarcoma: radiologic-pathologic correlation. RadioGraphics 23:1245-1278. 2003
                                      3. Aoki J et al: FDG-PET in differential diagnosis and grading of chondrosarcomas. J Comput Assist Tomogr. 23(4):603-8, 1999
                                      Related Anatomy
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                                      Related Differential Diagnoses
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                                      References
                                      Tables

                                      Tables

                                      KEY FACTS

                                      • Terminology

                                        • Imaging

                                          • Top Differential Diagnoses

                                            • Pathology

                                              • Clinical Issues

                                                TERMINOLOGY

                                                • Definitions

                                                  • Chondrosarcoma: Malignant cartilaginous tumor
                                                    • Primary: Arise from normal bone
                                                      • 3rd most common primary bone tumor
                                                    • Secondary: Arise from preexisting lesions (e.g., enchondroma, osteochondroma)
                                                  • Primary chondrosarcoma subtypes
                                                    • Intramedullary (most common)
                                                    • Clear cell
                                                    • Juxtacortical
                                                    • Myxoid
                                                    • Mesenchymal
                                                    • Extraskeletal
                                                    • Dedifferentiated
                                                  • Location
                                                    • Most chondrosarcomas occur in long bones (45%)
                                                      • Typically metaphyseal or metadiaphyseal
                                                    • Pelvis (25%)
                                                    • Less common locations: Ribs, spine, scapula, sternum, head & neck, craniofacial

                                                IMAGING

                                                • F-18 FDG PET/CT Findings

                                                  • Radiography Findings

                                                    • CT Findings

                                                      • MR Findings

                                                        • Nuclear Medicine

                                                          • Imaging Recommendations

                                                            DIFFERENTIAL DIAGNOSIS

                                                              PATHOLOGY

                                                              • General Features

                                                                • Staging, Grading, & Classification

                                                                  CLINICAL ISSUES

                                                                  • Presentation

                                                                    • Demographics

                                                                      • Natural History & Prognosis

                                                                        • Treatment

                                                                          Selected References

                                                                          1. Jesus-Garcia R et al: Is PET-CT an accurate method for the differential diagnosis between chondroma and chondrosarcoma? Springerplus. 5:236, 2016
                                                                          2. Murphey MD et al. Imaging of primary chondrosarcoma: radiologic-pathologic correlation. RadioGraphics 23:1245-1278. 2003
                                                                          3. Aoki J et al: FDG-PET in differential diagnosis and grading of chondrosarcomas. J Comput Assist Tomogr. 23(4):603-8, 1999