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Chondrosarcoma
Jeffrey S. Ross, MD
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KEY FACTS

  • Terminology

    • Imaging

      • Top Differential Diagnoses

        • Pathology

          • Clinical Issues

            • Diagnostic Checklist

              TERMINOLOGY

              • Abbreviations

                • Chondrosarcoma (CHS)
              • Definitions

                • Malignant tumor of connective tissue, characterized by formation of cartilage matrix by tumor cells

              IMAGING

              • General Features

                • Radiographic Findings

                  • CT Findings

                    • MR Findings

                      • Nuclear Medicine Findings

                        • Imaging Recommendations

                          DIFFERENTIAL DIAGNOSIS

                            PATHOLOGY

                            • General Features

                              • Staging, Grading, & Classification

                                • Gross Pathologic & Surgical Features

                                  • Microscopic Features

                                    • Histologic Subtypes

                                      CLINICAL ISSUES

                                      • Presentation

                                        • Demographics

                                          • Natural History & Prognosis

                                            • Treatment

                                              DIAGNOSTIC CHECKLIST

                                              • Consider

                                                Selected References

                                                1. Groves ML et al: Epidemiologic, functional, and oncologic outcome analysis of spinal sarcomas treated surgically at a single institution over 10 years. Spine J. ePub, 2014
                                                2. Ruivo C et al: Spinal chondrosarcoma arising from a solitary lumbar osteochondroma. JBR-BTR. 97(1):21-4, 2014
                                                3. Yin H et al: Prognostic factors of patients with spinal chondrosarcoma: a retrospective analysis of 98 consecutive patients in a single center. Ann Surg Oncol. 21(11):3572-8, 2014
                                                4. Boriani S et al: Challenges of local recurrence and cure in low grade malignant tumors of the spine. Spine (Phila Pa 1976). 34(22 Suppl):S48-57, 2009
                                                5. McLoughlin GS et al: Chondroma/Chondrosarcoma of the spine. Neurosurg Clin N Am. 19(1):57-63, 2008
                                                6. Rao G et al: Surgical management of primary and metastatic sarcoma of the mobile spine. J Neurosurg Spine. 9(2):120-8, 2008
                                                7. Lloret I et al: Primary spinal chondrosarcoma: radiologic findings with pathologic correlation. Acta Radiol. 47(1):77-84, 2006
                                                8. Murphey MD et al: From the archives of the AFIP: imaging of primary chondrosarcoma: radiologic-pathologic correlation. Radiographics. 23(5):1245-78, 2003
                                                9. Boriani S et al: Chondrosarcoma of the mobile spine: report on 22 cases. Spine (Phila Pa 1976). 25(7):804-12, 2000
                                                10. Björnsson J et al: Primary chondrosarcoma of long bones and limb girdles. Cancer. 83(10):2105-19, 1998
                                                11. Dorfman HD et al: Bone tumors. 1st ed. St. Louis: Mosby. 353-440, 1998
                                                12. Greenspan A et al: Differential diagnosis of tumors and tumor-like lesions of bones and joints. 1st ed. Philadelphia: Lippincott-Raven. 169-98, 1998
                                                13. Leis AA et al: Chondrosarcoma of the spine and thyroid carcinoma following radiation therapy for Hodgkin's lymphoma. Neurology. 48(6):1710-2, 1997
                                                14. Swarts SJ et al: Chromosomal abnormalities in low grade chondrosarcoma and a review of the literature. Cancer Genet Cytogenet. 98(2):126-30, 1997
                                                15. Mercuri M et al: Dedifferentiated chondrosarcoma. Skeletal Radiol. 24(6):409-16, 1995
                                                16. Aoki J et al: MR of enchondroma and chondrosarcoma: rings and arcs of Gd-DTPA enhancement. J Comput Assist Tomogr. 15(6):1011-6, 1991
                                                Related Anatomy
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                                                Related Differential Diagnoses
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                                                References
                                                Tables

                                                Tables

                                                KEY FACTS

                                                • Terminology

                                                  • Imaging

                                                    • Top Differential Diagnoses

                                                      • Pathology

                                                        • Clinical Issues

                                                          • Diagnostic Checklist

                                                            TERMINOLOGY

                                                            • Abbreviations

                                                              • Chondrosarcoma (CHS)
                                                            • Definitions

                                                              • Malignant tumor of connective tissue, characterized by formation of cartilage matrix by tumor cells

                                                            IMAGING

                                                            • General Features

                                                              • Radiographic Findings

                                                                • CT Findings

                                                                  • MR Findings

                                                                    • Nuclear Medicine Findings

                                                                      • Imaging Recommendations

                                                                        DIFFERENTIAL DIAGNOSIS

                                                                          PATHOLOGY

                                                                          • General Features

                                                                            • Staging, Grading, & Classification

                                                                              • Gross Pathologic & Surgical Features

                                                                                • Microscopic Features

                                                                                  • Histologic Subtypes

                                                                                    CLINICAL ISSUES

                                                                                    • Presentation

                                                                                      • Demographics

                                                                                        • Natural History & Prognosis

                                                                                          • Treatment

                                                                                            DIAGNOSTIC CHECKLIST

                                                                                            • Consider

                                                                                              Selected References

                                                                                              1. Groves ML et al: Epidemiologic, functional, and oncologic outcome analysis of spinal sarcomas treated surgically at a single institution over 10 years. Spine J. ePub, 2014
                                                                                              2. Ruivo C et al: Spinal chondrosarcoma arising from a solitary lumbar osteochondroma. JBR-BTR. 97(1):21-4, 2014
                                                                                              3. Yin H et al: Prognostic factors of patients with spinal chondrosarcoma: a retrospective analysis of 98 consecutive patients in a single center. Ann Surg Oncol. 21(11):3572-8, 2014
                                                                                              4. Boriani S et al: Challenges of local recurrence and cure in low grade malignant tumors of the spine. Spine (Phila Pa 1976). 34(22 Suppl):S48-57, 2009
                                                                                              5. McLoughlin GS et al: Chondroma/Chondrosarcoma of the spine. Neurosurg Clin N Am. 19(1):57-63, 2008
                                                                                              6. Rao G et al: Surgical management of primary and metastatic sarcoma of the mobile spine. J Neurosurg Spine. 9(2):120-8, 2008
                                                                                              7. Lloret I et al: Primary spinal chondrosarcoma: radiologic findings with pathologic correlation. Acta Radiol. 47(1):77-84, 2006
                                                                                              8. Murphey MD et al: From the archives of the AFIP: imaging of primary chondrosarcoma: radiologic-pathologic correlation. Radiographics. 23(5):1245-78, 2003
                                                                                              9. Boriani S et al: Chondrosarcoma of the mobile spine: report on 22 cases. Spine (Phila Pa 1976). 25(7):804-12, 2000
                                                                                              10. Björnsson J et al: Primary chondrosarcoma of long bones and limb girdles. Cancer. 83(10):2105-19, 1998
                                                                                              11. Dorfman HD et al: Bone tumors. 1st ed. St. Louis: Mosby. 353-440, 1998
                                                                                              12. Greenspan A et al: Differential diagnosis of tumors and tumor-like lesions of bones and joints. 1st ed. Philadelphia: Lippincott-Raven. 169-98, 1998
                                                                                              13. Leis AA et al: Chondrosarcoma of the spine and thyroid carcinoma following radiation therapy for Hodgkin's lymphoma. Neurology. 48(6):1710-2, 1997
                                                                                              14. Swarts SJ et al: Chromosomal abnormalities in low grade chondrosarcoma and a review of the literature. Cancer Genet Cytogenet. 98(2):126-30, 1997
                                                                                              15. Mercuri M et al: Dedifferentiated chondrosarcoma. Skeletal Radiol. 24(6):409-16, 1995
                                                                                              16. Aoki J et al: MR of enchondroma and chondrosarcoma: rings and arcs of Gd-DTPA enhancement. J Comput Assist Tomogr. 15(6):1011-6, 1991