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Choroid Plexus Carcinoma
Anne G. Osborn, MD, FACR; Chang Yueh Ho, MD
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KEY FACTS

  • Terminology

    • Imaging

      • Top Differential Diagnoses

        • Pathology

          • Clinical Issues

            TERMINOLOGY

            • Abbreviations

              • Choroid plexus carcinoma (CPCa)
            • Definitions

              • Malignant tumor originating from epithelium of choroid plexus

            IMAGING

            • General Features

              • CT Findings

                • MR Findings

                  • Ultrasonographic Findings

                    • Angiographic Findings

                      • Nuclear Medicine Findings

                        • Imaging Recommendations

                          DIFFERENTIAL DIAGNOSIS

                            PATHOLOGY

                            • General Features

                              • Staging, Grading, & Classification

                                • Gross Pathologic & Surgical Features

                                  • Microscopic Features

                                    CLINICAL ISSUES

                                    • Presentation

                                      • Demographics

                                        • Natural History & Prognosis

                                          • Treatment

                                            DIAGNOSTIC CHECKLIST

                                            • Consider

                                              • Image Interpretation Pearls

                                                Selected References

                                                1. Crea A et al: Choroid plexus carcinoma in adults: Literature review and first report of a location into the third ventricle. World Neurosurg. 133:302-7, 2020
                                                2. Orr BA et al: An update on the central nervous system manifestations of Li-Fraumeni syndrome. Acta Neuropathol. 139(4):669-87, 2020
                                                3. Thomas C et al: Epigenetics impacts upon prognosis and clinical management of choroid plexus tumors. J Neurooncol. 148(1):39-45, 2020
                                                4. Crawford JR et al: Perinatal (fetal and neonatal) choroid plexus tumors: a review. Childs Nerv Syst. 35(6):937-44, 2019
                                                5. Dash C et al: Management of choroid plexus tumors in infants and young children up to 4 years of age: an institutional experience. World Neurosurg. 121:e237-45, 2019
                                                6. Hosmann A et al: Management of choroid plexus tumors-an institutional experience. Acta Neurochir (Wien). 161(4):745-54, 2019
                                                7. Lin H et al: Choroid plexus tumours on MRI: similarities and distinctions in different grades. Cancer Imaging. 19(1):17, 2019
                                                8. Pienkowska M et al: DNA methylation signature is prognostic of choroid plexus tumor aggressiveness. Clin Epigenetics. 11(1):117, 2019
                                                9. Muly S et al: MRI of intracranial intraventricular lesions. Clin Imaging. 52:226-39, 2018
                                                10. Sasaki T et al: Roles of the apparent diffusion coefficient and tumor volume in predicting tumor grade in patients with choroid plexus tumors. Neuroradiology. 60(5):479-86, 2018
                                                11. Bahar M et al: Choroid plexus tumors in adult and pediatric populations: the Cleveland Clinic and University Hospitals experience. J Neurooncol. 132(3):427-32, 2017
                                                12. Thomas C et al: Methylation profiling of choroid plexus tumors reveals 3 clinically distinct subgroups. Neuro Oncol. 18(6):790-6, 2016
                                                13. Cannon DM et al: Choroid plexus tumor epidemiology and outcomes: implications for surgical and radiotherapeutic management. J Neurooncol. 121(1):151-7, 2015
                                                14. Dangouloff-Ros V et al: Choroid plexus neoplasms: Toward a distinction between carcinoma and papilloma using arterial spin-labeling. AJNR Am J Neuroradiol. 36(9):1786-90, 2015
                                                15. Zaky W et al: Choroid plexus carcinoma in children: The Head Start experience. Pediatr Blood Cancer. 62(5):784-9, 2015
                                                16. Ruland V et al: Choroid plexus carcinomas are characterized by complex chromosomal alterations related to patient age and prognosis. Genes Chromosomes Cancer. 53(5):373-80, 2014
                                                Related Anatomy
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                                                Related Differential Diagnoses
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                                                References
                                                Tables

                                                Tables

                                                KEY FACTS

                                                • Terminology

                                                  • Imaging

                                                    • Top Differential Diagnoses

                                                      • Pathology

                                                        • Clinical Issues

                                                          TERMINOLOGY

                                                          • Abbreviations

                                                            • Choroid plexus carcinoma (CPCa)
                                                          • Definitions

                                                            • Malignant tumor originating from epithelium of choroid plexus

                                                          IMAGING

                                                          • General Features

                                                            • CT Findings

                                                              • MR Findings

                                                                • Ultrasonographic Findings

                                                                  • Angiographic Findings

                                                                    • Nuclear Medicine Findings

                                                                      • Imaging Recommendations

                                                                        DIFFERENTIAL DIAGNOSIS

                                                                          PATHOLOGY

                                                                          • General Features

                                                                            • Staging, Grading, & Classification

                                                                              • Gross Pathologic & Surgical Features

                                                                                • Microscopic Features

                                                                                  CLINICAL ISSUES

                                                                                  • Presentation

                                                                                    • Demographics

                                                                                      • Natural History & Prognosis

                                                                                        • Treatment

                                                                                          DIAGNOSTIC CHECKLIST

                                                                                          • Consider

                                                                                            • Image Interpretation Pearls

                                                                                              Selected References

                                                                                              1. Crea A et al: Choroid plexus carcinoma in adults: Literature review and first report of a location into the third ventricle. World Neurosurg. 133:302-7, 2020
                                                                                              2. Orr BA et al: An update on the central nervous system manifestations of Li-Fraumeni syndrome. Acta Neuropathol. 139(4):669-87, 2020
                                                                                              3. Thomas C et al: Epigenetics impacts upon prognosis and clinical management of choroid plexus tumors. J Neurooncol. 148(1):39-45, 2020
                                                                                              4. Crawford JR et al: Perinatal (fetal and neonatal) choroid plexus tumors: a review. Childs Nerv Syst. 35(6):937-44, 2019
                                                                                              5. Dash C et al: Management of choroid plexus tumors in infants and young children up to 4 years of age: an institutional experience. World Neurosurg. 121:e237-45, 2019
                                                                                              6. Hosmann A et al: Management of choroid plexus tumors-an institutional experience. Acta Neurochir (Wien). 161(4):745-54, 2019
                                                                                              7. Lin H et al: Choroid plexus tumours on MRI: similarities and distinctions in different grades. Cancer Imaging. 19(1):17, 2019
                                                                                              8. Pienkowska M et al: DNA methylation signature is prognostic of choroid plexus tumor aggressiveness. Clin Epigenetics. 11(1):117, 2019
                                                                                              9. Muly S et al: MRI of intracranial intraventricular lesions. Clin Imaging. 52:226-39, 2018
                                                                                              10. Sasaki T et al: Roles of the apparent diffusion coefficient and tumor volume in predicting tumor grade in patients with choroid plexus tumors. Neuroradiology. 60(5):479-86, 2018
                                                                                              11. Bahar M et al: Choroid plexus tumors in adult and pediatric populations: the Cleveland Clinic and University Hospitals experience. J Neurooncol. 132(3):427-32, 2017
                                                                                              12. Thomas C et al: Methylation profiling of choroid plexus tumors reveals 3 clinically distinct subgroups. Neuro Oncol. 18(6):790-6, 2016
                                                                                              13. Cannon DM et al: Choroid plexus tumor epidemiology and outcomes: implications for surgical and radiotherapeutic management. J Neurooncol. 121(1):151-7, 2015
                                                                                              14. Dangouloff-Ros V et al: Choroid plexus neoplasms: Toward a distinction between carcinoma and papilloma using arterial spin-labeling. AJNR Am J Neuroradiol. 36(9):1786-90, 2015
                                                                                              15. Zaky W et al: Choroid plexus carcinoma in children: The Head Start experience. Pediatr Blood Cancer. 62(5):784-9, 2015
                                                                                              16. Ruland V et al: Choroid plexus carcinomas are characterized by complex chromosomal alterations related to patient age and prognosis. Genes Chromosomes Cancer. 53(5):373-80, 2014