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Choroid Plexus Carcinoma
Chang Yueh Ho, MD
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KEY FACTS

  • Terminology

    • Imaging

      • Top Differential Diagnoses

        • Pathology

          • Clinical Issues

            TERMINOLOGY

            • Abbreviations

              • Choroid plexus carcinoma (CPCa)
            • Definitions

              • Malignant tumor originating from epithelium of choroid plexus

            IMAGING

            • General Features

              • CT Findings

                • MR Findings

                  • Ultrasonographic Findings

                    • Angiographic Findings

                      • Nuclear Medicine Findings

                        • Imaging Recommendations

                          DIFFERENTIAL DIAGNOSIS

                            PATHOLOGY

                            • General Features

                              • Staging, Grading, & Classification

                                • Gross Pathologic & Surgical Features

                                  • Microscopic Features

                                    • Immunochemistry

                                      • Genetic Alterations

                                        CLINICAL ISSUES

                                        • Presentation

                                          • Demographics

                                            • Natural History & Prognosis

                                              • Treatment

                                                DIAGNOSTIC CHECKLIST

                                                • Consider

                                                  • Image Interpretation Pearls

                                                    Selected References

                                                    1. Ruland V et al: Choroid plexus carcinomas are characterized by complex chromosomal alterations related to patient age and prognosis. Genes Chromosomes Cancer. 53(5):373-80, 2014
                                                    2. Korchi AM et al: Pseudoprogression after proton beam irradiation for a choroid plexus carcinoma in pediatric patient: MRI and PET imaging patterns. Childs Nerv Syst. 29(3):509-12, 2013
                                                    3. Gonzalez KD et al: Beyond Li Fraumeni syndrome: clinical characteristics of families with p53 germline mutations. J Clin Oncol. 27(8):1250-6, 2009
                                                    4. Gopal P et al: Choroid plexus carcinoma. Arch Pathol Lab Med. 132(8):1350-4, 2008
                                                    5. Wrede B et al: Chemotherapy improves the survival of patients with choroid plexus carcinoma: a meta-analysis of individual cases with choroid plexus tumors. J Neurooncol. 85(3):345-51, 2007
                                                    6. Levy ML et al: Choroid plexus tumors in children: significance of stromal invasion. Neurosurgery. 48(2):303-9, 2001
                                                    7. Malkin D et al: Tissue-specific expression of SV40 in tumors associated with the Li-Fraumeni syndrome. Oncogene. 20(33):4441-9, 2001
                                                    8. Poussaint TY: Magnetic resonance imaging of pediatric brain tumors: state of the art. Top Magn Reson Imaging. 12(6):411-33, 2001
                                                    9. Wolff JE et al: Detection of choroid plexus carcinoma with Tc-99m sestamibi: case report and review of the literature. Med Pediatr Oncol. 36(2):323-5, 2001
                                                    10. Wyatt-Ashmead J et al: Choroid plexus carcinomas and rhabdoid tumors: phenotypic and genotypic overlap. Pediatr Dev Pathol. 4(6):545-9, 2001
                                                    11. Sévenet N et al: Constitutional mutations of the hSNF5/INI1 gene predispose to a variety of cancers. Am J Hum Genet. 65(5):1342-8, 1999
                                                    Related Anatomy
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                                                    Related Differential Diagnoses
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                                                    References
                                                    Tables

                                                    Tables

                                                    KEY FACTS

                                                    • Terminology

                                                      • Imaging

                                                        • Top Differential Diagnoses

                                                          • Pathology

                                                            • Clinical Issues

                                                              TERMINOLOGY

                                                              • Abbreviations

                                                                • Choroid plexus carcinoma (CPCa)
                                                              • Definitions

                                                                • Malignant tumor originating from epithelium of choroid plexus

                                                              IMAGING

                                                              • General Features

                                                                • CT Findings

                                                                  • MR Findings

                                                                    • Ultrasonographic Findings

                                                                      • Angiographic Findings

                                                                        • Nuclear Medicine Findings

                                                                          • Imaging Recommendations

                                                                            DIFFERENTIAL DIAGNOSIS

                                                                              PATHOLOGY

                                                                              • General Features

                                                                                • Staging, Grading, & Classification

                                                                                  • Gross Pathologic & Surgical Features

                                                                                    • Microscopic Features

                                                                                      • Immunochemistry

                                                                                        • Genetic Alterations

                                                                                          CLINICAL ISSUES

                                                                                          • Presentation

                                                                                            • Demographics

                                                                                              • Natural History & Prognosis

                                                                                                • Treatment

                                                                                                  DIAGNOSTIC CHECKLIST

                                                                                                  • Consider

                                                                                                    • Image Interpretation Pearls

                                                                                                      Selected References

                                                                                                      1. Ruland V et al: Choroid plexus carcinomas are characterized by complex chromosomal alterations related to patient age and prognosis. Genes Chromosomes Cancer. 53(5):373-80, 2014
                                                                                                      2. Korchi AM et al: Pseudoprogression after proton beam irradiation for a choroid plexus carcinoma in pediatric patient: MRI and PET imaging patterns. Childs Nerv Syst. 29(3):509-12, 2013
                                                                                                      3. Gonzalez KD et al: Beyond Li Fraumeni syndrome: clinical characteristics of families with p53 germline mutations. J Clin Oncol. 27(8):1250-6, 2009
                                                                                                      4. Gopal P et al: Choroid plexus carcinoma. Arch Pathol Lab Med. 132(8):1350-4, 2008
                                                                                                      5. Wrede B et al: Chemotherapy improves the survival of patients with choroid plexus carcinoma: a meta-analysis of individual cases with choroid plexus tumors. J Neurooncol. 85(3):345-51, 2007
                                                                                                      6. Levy ML et al: Choroid plexus tumors in children: significance of stromal invasion. Neurosurgery. 48(2):303-9, 2001
                                                                                                      7. Malkin D et al: Tissue-specific expression of SV40 in tumors associated with the Li-Fraumeni syndrome. Oncogene. 20(33):4441-9, 2001
                                                                                                      8. Poussaint TY: Magnetic resonance imaging of pediatric brain tumors: state of the art. Top Magn Reson Imaging. 12(6):411-33, 2001
                                                                                                      9. Wolff JE et al: Detection of choroid plexus carcinoma with Tc-99m sestamibi: case report and review of the literature. Med Pediatr Oncol. 36(2):323-5, 2001
                                                                                                      10. Wyatt-Ashmead J et al: Choroid plexus carcinomas and rhabdoid tumors: phenotypic and genotypic overlap. Pediatr Dev Pathol. 4(6):545-9, 2001
                                                                                                      11. Sévenet N et al: Constitutional mutations of the hSNF5/INI1 gene predispose to a variety of cancers. Am J Hum Genet. 65(5):1342-8, 1999