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Choroid Plexus Papilloma
Anne G. Osborn, MD, FACR; Chang Yueh Ho, MD
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KEY FACTS

  • Terminology

    • Imaging

      • Top Differential Diagnoses

        • Clinical Issues

          • Diagnostic Checklist

            TERMINOLOGY

            • Abbreviations

              • Choroid plexus tumor (CPT)
                • 3 recognized subtypes
                  • Choroid plexus papilloma (CPP)
                  • Atypical choroid plexus papilloma (aCPP)
                  • Choroid plexus carcinoma (CPCa)
            • Definitions

              • Benign (WHO grade 1) papillary neoplasm derived from choroid plexus (CP) epithelium

            IMAGING

            • General Features

              • Radiographic Findings

                • CT Findings

                  • MR Findings

                    • Ultrasonographic Findings

                      • Angiographic Findings

                        • Nuclear Medicine Findings

                          • Imaging Recommendations

                            DIFFERENTIAL DIAGNOSIS

                              PATHOLOGY

                              • General Features

                                • Staging, Grading, & Classification

                                  • Gross Pathologic & Surgical Features

                                    • Microscopic Features

                                      CLINICAL ISSUES

                                      • Presentation

                                        • Demographics

                                          • Natural History & Prognosis

                                            • Treatment

                                              DIAGNOSTIC CHECKLIST

                                              • Consider

                                                • Image Interpretation Pearls

                                                  Selected References

                                                  1. Crea A et al: Choroid plexus carcinoma in adults: Literature review and first report of a location into the third ventricle. World Neurosurg. 133:302-7, 2020
                                                  2. Pfeifer CM et al: Third ventricle choroid plexus papilloma: 2 cases. Radiol Case Rep. 15(5):454-6, 2020
                                                  3. Thomas C et al: Epigenetics impacts upon prognosis and clinical management of choroid plexus tumors. J Neurooncol. 148(1):39-45, 2020
                                                  4. Trybula SJ et al: Infratentorial choroid plexus tumors in children. Childs Nerv Syst. 36(8):1781-6, 2020
                                                  5. Chen T et al: Temporal horn choroid plexus papilloma presenting with seizures in adulthood: clinical case report and review of the literature. World Neurosurg. 132:403-7, 2019
                                                  6. Dash C et al: Management of choroid plexus tumors in infants and young children up to 4 years of age: an institutional experience. World Neurosurg. 121:e237-45, 2019
                                                  7. Lin H et al: Choroid plexus tumours on MRI: similarities and distinctions in different grades. Cancer Imaging. 19(1):17, 2019
                                                  8. Puerta Roldán P et al: Vanishing diffuse leptomeningeal contrast enhancement in an infant with choroid plexus papilloma. Acta Neurochir (Wien). 161(2):351-4, 2019
                                                  9. Muly S et al: MRI of intracranial intraventricular lesions. Clin Imaging. 52:226-39, 2018
                                                  10. Bahar M et al: Choroid plexus tumors in adult and pediatric populations: the Cleveland Clinic and University Hospitals experience. J Neurooncol. ePub, 2017
                                                  11. Shi YZ et al: Atypical choroid plexus papilloma: clinicopathological and neuroradiological features. Acta Radiol. 284185116676651, 2017
                                                  12. Thomas C et al: Methylation profiling of choroid plexus tumors reveals 3 clinically distinct subgroups. Neuro Oncol. ePub, 2016
                                                  13. Cannon DM et al: Choroid plexus tumor epidemiology and outcomes: implications for surgical and radiotherapeutic management. J Neurooncol. 121(1):151-7, 2015
                                                  14. Japp AS et al: High-resolution genomic analysis does not qualify atypical plexus papilloma as a separate entity among choroid plexus tumors. J Neuropathol Exp Neurol. 74(2):110-20, 2015
                                                  15. Thomas C et al: Pediatric atypical choroid plexus papilloma reconsidered: increased mitotic activity is prognostic only in older children. Acta Neuropathol. ePub, 2015
                                                  16. Ogiwara H et al: Choroid plexus tumors in pediatric patients. Br J Neurosurg. 26(1):32-7, 2012
                                                  Related Anatomy
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                                                  Related Differential Diagnoses
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                                                  References
                                                  Tables

                                                  Tables

                                                  KEY FACTS

                                                  • Terminology

                                                    • Imaging

                                                      • Top Differential Diagnoses

                                                        • Clinical Issues

                                                          • Diagnostic Checklist

                                                            TERMINOLOGY

                                                            • Abbreviations

                                                              • Choroid plexus tumor (CPT)
                                                                • 3 recognized subtypes
                                                                  • Choroid plexus papilloma (CPP)
                                                                  • Atypical choroid plexus papilloma (aCPP)
                                                                  • Choroid plexus carcinoma (CPCa)
                                                            • Definitions

                                                              • Benign (WHO grade 1) papillary neoplasm derived from choroid plexus (CP) epithelium

                                                            IMAGING

                                                            • General Features

                                                              • Radiographic Findings

                                                                • CT Findings

                                                                  • MR Findings

                                                                    • Ultrasonographic Findings

                                                                      • Angiographic Findings

                                                                        • Nuclear Medicine Findings

                                                                          • Imaging Recommendations

                                                                            DIFFERENTIAL DIAGNOSIS

                                                                              PATHOLOGY

                                                                              • General Features

                                                                                • Staging, Grading, & Classification

                                                                                  • Gross Pathologic & Surgical Features

                                                                                    • Microscopic Features

                                                                                      CLINICAL ISSUES

                                                                                      • Presentation

                                                                                        • Demographics

                                                                                          • Natural History & Prognosis

                                                                                            • Treatment

                                                                                              DIAGNOSTIC CHECKLIST

                                                                                              • Consider

                                                                                                • Image Interpretation Pearls

                                                                                                  Selected References

                                                                                                  1. Crea A et al: Choroid plexus carcinoma in adults: Literature review and first report of a location into the third ventricle. World Neurosurg. 133:302-7, 2020
                                                                                                  2. Pfeifer CM et al: Third ventricle choroid plexus papilloma: 2 cases. Radiol Case Rep. 15(5):454-6, 2020
                                                                                                  3. Thomas C et al: Epigenetics impacts upon prognosis and clinical management of choroid plexus tumors. J Neurooncol. 148(1):39-45, 2020
                                                                                                  4. Trybula SJ et al: Infratentorial choroid plexus tumors in children. Childs Nerv Syst. 36(8):1781-6, 2020
                                                                                                  5. Chen T et al: Temporal horn choroid plexus papilloma presenting with seizures in adulthood: clinical case report and review of the literature. World Neurosurg. 132:403-7, 2019
                                                                                                  6. Dash C et al: Management of choroid plexus tumors in infants and young children up to 4 years of age: an institutional experience. World Neurosurg. 121:e237-45, 2019
                                                                                                  7. Lin H et al: Choroid plexus tumours on MRI: similarities and distinctions in different grades. Cancer Imaging. 19(1):17, 2019
                                                                                                  8. Puerta Roldán P et al: Vanishing diffuse leptomeningeal contrast enhancement in an infant with choroid plexus papilloma. Acta Neurochir (Wien). 161(2):351-4, 2019
                                                                                                  9. Muly S et al: MRI of intracranial intraventricular lesions. Clin Imaging. 52:226-39, 2018
                                                                                                  10. Bahar M et al: Choroid plexus tumors in adult and pediatric populations: the Cleveland Clinic and University Hospitals experience. J Neurooncol. ePub, 2017
                                                                                                  11. Shi YZ et al: Atypical choroid plexus papilloma: clinicopathological and neuroradiological features. Acta Radiol. 284185116676651, 2017
                                                                                                  12. Thomas C et al: Methylation profiling of choroid plexus tumors reveals 3 clinically distinct subgroups. Neuro Oncol. ePub, 2016
                                                                                                  13. Cannon DM et al: Choroid plexus tumor epidemiology and outcomes: implications for surgical and radiotherapeutic management. J Neurooncol. 121(1):151-7, 2015
                                                                                                  14. Japp AS et al: High-resolution genomic analysis does not qualify atypical plexus papilloma as a separate entity among choroid plexus tumors. J Neuropathol Exp Neurol. 74(2):110-20, 2015
                                                                                                  15. Thomas C et al: Pediatric atypical choroid plexus papilloma reconsidered: increased mitotic activity is prognostic only in older children. Acta Neuropathol. ePub, 2015
                                                                                                  16. Ogiwara H et al: Choroid plexus tumors in pediatric patients. Br J Neurosurg. 26(1):32-7, 2012