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Choroid Plexus Papilloma
Luke L. Linscott, MD
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KEY FACTS

  • Terminology

    • Imaging

      • Top Differential Diagnoses

        • Clinical Issues

          • Diagnostic Checklist

            TERMINOLOGY

            • Abbreviations

              • Choroid plexus papilloma (CPP)
                • Atypical choroid plexus papilloma (aCPP)
              • Choroid plexus tumor (CPT)
              • Choroid plexus carcinoma (CPC)
            • Definitions

              • Intraventricular, papillary neoplasm derived from choroid plexus epithelium (WHO grade I or II)

            IMAGING

            • General Features

              • Radiographic Findings

                • CT Findings

                  • MR Findings

                    • Ultrasonographic Findings

                      • Angiographic Findings

                        • Nuclear Medicine Findings

                          • Imaging Recommendations

                            DIFFERENTIAL DIAGNOSIS

                              PATHOLOGY

                              • General Features

                                • Staging, Grading, & Classification

                                  • Gross Pathologic & Surgical Features

                                    • Microscopic Features

                                      CLINICAL ISSUES

                                      • Presentation

                                        • Demographics

                                          • Natural History & Prognosis

                                            • Treatment

                                              DIAGNOSTIC CHECKLIST

                                              • Consider

                                                • Image Interpretation Pearls

                                                  Selected References

                                                  1. Crawford JR et al: Perinatal (fetal and neonatal) choroid plexus tumors: a review. Childs Nerv Syst. ePub, 2019
                                                  2. Sasaki T et al: Roles of the apparent diffusion coefficient and tumor volume in predicting tumor grade in patients with choroid plexus tumors. Neuroradiology. 60(5):479-86, 2018
                                                  3. Siegfried A et al: A French retrospective study on clinical outcome in 102 choroid plexus tumors in children. J Neurooncol. 135(1):151-160, 2017
                                                  4. Thomas C et al: Methylation profiling of choroid plexus tumors reveals 3 clinically distinct subgroups. Neuro Oncol. ePub, 2016
                                                  5. Dangouloff-Ros V et al: Choroid plexus neoplasms: toward a distinction between carcinoma and papilloma using arterial spin-labeling. AJNR Am J Neuroradiol. 36(9):1786-90, 2015
                                                  6. Dudley RW et al: Pediatric choroid plexus tumors: epidemiology, treatments, and outcome analysis on 202 children from the SEER database. J Neurooncol. 121(1):201-7, 2015
                                                  7. Merino DM et al: Molecular characterization of choroid plexus tumors reveals novel clinically relevant subgroups. Clin Cancer Res. 21(1):184-92, 2015
                                                  8. Gupta P et al: Choroid plexus papilloma of the third ventricle: A rare infantile brain tumor. J Pediatr Neurosci. 8(3):247-9, 2013
                                                  9. Safaee M et al: Surgical outcomes in choroid plexus papillomas: an institutional experience. J Neurooncol. 113(1):117-25, 2013
                                                  10. Lysyy O et al: Choroid plexus papilloma in an infant: ultrasound diagnosis. Eur J Pediatr. 171(11):1717-8, 2012
                                                  11. Ogiwara H et al: Choroid plexus tumors in pediatric patients. Br J Neurosurg. 26(1):32-7, 2012
                                                  12. Hasselblatt M et al: TWIST-1 is overexpressed in neoplastic choroid plexus epithelial cells and promotes proliferation and invasion. Cancer Res. 69(6):2219-23, 2009
                                                  13. Naeini RM et al: Spectrum of choroid plexus lesions in children. AJR Am J Roentgenol. 192(1):32-40, 2009
                                                  14. Ma YH et al: Primary choroid plexus papilloma of the sellar region. J Neurooncol. 88(1):51-5, 2008
                                                  15. Jeibmann A et al: Malignant progression in choroid plexus papillomas. J Neurosurg. 107(3 Suppl):199-202, 2007
                                                  16. Jinhu Y et al: Metastasis of a histologically benign choroid plexus papilloma: case report and review of the literature. J Neurooncol. 83(1):47-52, 2007
                                                  17. Kaptanoglu E et al: Spinal drop metastasis of choroid plexus papilloma. J Clin Neurosci. 14(4):381-3, 2007
                                                  18. Ortega-Martínez M et al: Diffuse leptomeningeal seeding from benign choroid plexus papilloma. Acta Neurochir (Wien). 149(12):1229-36; discussion 1236-7, 2007
                                                  19. Krieger MD et al: Differentiation of choroid plexus tumors by advanced magnetic resonance spectroscopy. Neurosurg Focus. 18(6A):E4, 2005
                                                  20. Rickert CH et al: Tumors of the choroid plexus. Microsc Res Tech. 52(1):104-11, 2001
                                                  Related Anatomy
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                                                  Related Differential Diagnoses
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                                                  References
                                                  Tables

                                                  Tables

                                                  KEY FACTS

                                                  • Terminology

                                                    • Imaging

                                                      • Top Differential Diagnoses

                                                        • Clinical Issues

                                                          • Diagnostic Checklist

                                                            TERMINOLOGY

                                                            • Abbreviations

                                                              • Choroid plexus papilloma (CPP)
                                                                • Atypical choroid plexus papilloma (aCPP)
                                                              • Choroid plexus tumor (CPT)
                                                              • Choroid plexus carcinoma (CPC)
                                                            • Definitions

                                                              • Intraventricular, papillary neoplasm derived from choroid plexus epithelium (WHO grade I or II)

                                                            IMAGING

                                                            • General Features

                                                              • Radiographic Findings

                                                                • CT Findings

                                                                  • MR Findings

                                                                    • Ultrasonographic Findings

                                                                      • Angiographic Findings

                                                                        • Nuclear Medicine Findings

                                                                          • Imaging Recommendations

                                                                            DIFFERENTIAL DIAGNOSIS

                                                                              PATHOLOGY

                                                                              • General Features

                                                                                • Staging, Grading, & Classification

                                                                                  • Gross Pathologic & Surgical Features

                                                                                    • Microscopic Features

                                                                                      CLINICAL ISSUES

                                                                                      • Presentation

                                                                                        • Demographics

                                                                                          • Natural History & Prognosis

                                                                                            • Treatment

                                                                                              DIAGNOSTIC CHECKLIST

                                                                                              • Consider

                                                                                                • Image Interpretation Pearls

                                                                                                  Selected References

                                                                                                  1. Crawford JR et al: Perinatal (fetal and neonatal) choroid plexus tumors: a review. Childs Nerv Syst. ePub, 2019
                                                                                                  2. Sasaki T et al: Roles of the apparent diffusion coefficient and tumor volume in predicting tumor grade in patients with choroid plexus tumors. Neuroradiology. 60(5):479-86, 2018
                                                                                                  3. Siegfried A et al: A French retrospective study on clinical outcome in 102 choroid plexus tumors in children. J Neurooncol. 135(1):151-160, 2017
                                                                                                  4. Thomas C et al: Methylation profiling of choroid plexus tumors reveals 3 clinically distinct subgroups. Neuro Oncol. ePub, 2016
                                                                                                  5. Dangouloff-Ros V et al: Choroid plexus neoplasms: toward a distinction between carcinoma and papilloma using arterial spin-labeling. AJNR Am J Neuroradiol. 36(9):1786-90, 2015
                                                                                                  6. Dudley RW et al: Pediatric choroid plexus tumors: epidemiology, treatments, and outcome analysis on 202 children from the SEER database. J Neurooncol. 121(1):201-7, 2015
                                                                                                  7. Merino DM et al: Molecular characterization of choroid plexus tumors reveals novel clinically relevant subgroups. Clin Cancer Res. 21(1):184-92, 2015
                                                                                                  8. Gupta P et al: Choroid plexus papilloma of the third ventricle: A rare infantile brain tumor. J Pediatr Neurosci. 8(3):247-9, 2013
                                                                                                  9. Safaee M et al: Surgical outcomes in choroid plexus papillomas: an institutional experience. J Neurooncol. 113(1):117-25, 2013
                                                                                                  10. Lysyy O et al: Choroid plexus papilloma in an infant: ultrasound diagnosis. Eur J Pediatr. 171(11):1717-8, 2012
                                                                                                  11. Ogiwara H et al: Choroid plexus tumors in pediatric patients. Br J Neurosurg. 26(1):32-7, 2012
                                                                                                  12. Hasselblatt M et al: TWIST-1 is overexpressed in neoplastic choroid plexus epithelial cells and promotes proliferation and invasion. Cancer Res. 69(6):2219-23, 2009
                                                                                                  13. Naeini RM et al: Spectrum of choroid plexus lesions in children. AJR Am J Roentgenol. 192(1):32-40, 2009
                                                                                                  14. Ma YH et al: Primary choroid plexus papilloma of the sellar region. J Neurooncol. 88(1):51-5, 2008
                                                                                                  15. Jeibmann A et al: Malignant progression in choroid plexus papillomas. J Neurosurg. 107(3 Suppl):199-202, 2007
                                                                                                  16. Jinhu Y et al: Metastasis of a histologically benign choroid plexus papilloma: case report and review of the literature. J Neurooncol. 83(1):47-52, 2007
                                                                                                  17. Kaptanoglu E et al: Spinal drop metastasis of choroid plexus papilloma. J Clin Neurosci. 14(4):381-3, 2007
                                                                                                  18. Ortega-Martínez M et al: Diffuse leptomeningeal seeding from benign choroid plexus papilloma. Acta Neurochir (Wien). 149(12):1229-36; discussion 1236-7, 2007
                                                                                                  19. Krieger MD et al: Differentiation of choroid plexus tumors by advanced magnetic resonance spectroscopy. Neurosurg Focus. 18(6A):E4, 2005
                                                                                                  20. Rickert CH et al: Tumors of the choroid plexus. Microsc Res Tech. 52(1):104-11, 2001