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Choroid Plexus Tumors
Luke L. Linscott, MD
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KEY FACTS

  • Terminology

    • Imaging

      • Top Differential Diagnoses

        • Pathology

          • Clinical Issues

            • Diagnostic Checklist

              TERMINOLOGY

              • Abbreviations

                • Choroid plexus tumor (CPT)
                  • Choroid plexus papilloma (CPP): WHO grade 1
                  • Atypical choroid plexus papilloma (aCPP): WHO grade 2
                  • Choroid plexus carcinoma (CPCa): WHO grade 3
              • Definitions

                • Intraventricular, papillary neoplasm of CP epithelium

              IMAGING

              • General Features

                • CT Findings

                  • MR Findings

                    • Ultrasonographic Findings

                      • Angiographic Findings

                        • Nuclear Medicine Findings

                          • Imaging Recommendations

                            DIFFERENTIAL DIAGNOSIS

                              PATHOLOGY

                              • General Features

                                • Staging, Grading, & Classification

                                  • Gross Pathologic & Surgical Features

                                    • Microscopic Features

                                      CLINICAL ISSUES

                                      • Presentation

                                        • Demographics

                                          • Natural History & Prognosis

                                            • Treatment

                                              DIAGNOSTIC CHECKLIST

                                              • Consider

                                                Selected References

                                                1. Trybula SJ et al: Infratentorial choroid plexus tumors in children. Childs Nerv Syst. 36(8):1761-6, 2020
                                                2. Crawford JR et al: Perinatal (fetal and neonatal) choroid plexus tumors: a review. Childs Nerv Syst. 35(6):937-44, 2019
                                                3. Dash C et al: Management of choroid plexus tumors in infants and young children up to 4 years of age: an institutional experience. World Neurosurg. 121:e237-45, 2019
                                                4. Sasaki T et al: Roles of the apparent diffusion coefficient and tumor volume in predicting tumor grade in patients with choroid plexus tumors. Neuroradiology. 60(5):479-86, 2018
                                                5. Zhou WJ et al: Clinical features and prognostic risk factors of choroid plexus tumors in children. Chin Med J (Engl). 131(24):2938-46, 2018
                                                6. Siegfried A et al: A French retrospective study on clinical outcome in 102 choroid plexus tumors in children. J Neurooncol. 135(1):151-60, 2017
                                                7. Thomas C et al: Methylation profiling of choroid plexus tumors reveals 3 clinically distinct subgroups. Neuro Oncol. 18(6):790-6, 2016
                                                8. Dangouloff-Ros V et al: Choroid plexus neoplasms: toward a distinction between carcinoma and papilloma using arterial spin-labeling. AJNR Am J Neuroradiol. 36(9):1786-90, 2015
                                                9. Dudley RW et al: Pediatric choroid plexus tumors: epidemiology, treatments, and outcome analysis on 202 children from the SEER database. J Neurooncol. 121(1):201-7, 2015
                                                10. Merino DM et al: Molecular characterization of choroid plexus tumors reveals novel clinically relevant subgroups. Clin Cancer Res. 21(1):184-92, 2015
                                                11. Jaiswal S et al: Choroid plexus tumors: a clinico-pathological and neuro-radiological study of 23 cases. Asian J Neurosurg. 8(1):29-35, 2013
                                                12. Lam S et al: Choroid plexus tumors in children: a population-based study. Pediatr Neurosurg. 49(6):331-8, 2013
                                                13. Yan C et al: Choroid plexus tumours: classification, MR imaging findings and pathological correlation. J Med Imaging Radiat Oncol. 57(2):176-83, 2013
                                                14. Lafay-Cousin L et al: Choroid plexus tumors in children less than 36 months: the Canadian Pediatric Brain Tumor Consortium (CPBTC) experience. Childs Nerv Syst. 27(2):259-64, 2011
                                                15. Krieger MD et al: Differentiation of choroid plexus tumors by advanced magnetic resonance spectroscopy. Neurosurg Focus. 18(6A):E4, 2005
                                                16. Fujimura M et al: Hydrocephalus due to cerebrospinal fluid overproduction by bilateral choroid plexus papillomas. Childs Nerv Syst. 20(7):485-8, 2004
                                                17. Meyers SP et al: Choroid plexus carcinomas in children: MRI features and patient outcomes. Neuroradiology. 46(9):770-80, 2004
                                                18. Koeller KK et al: From the archives of the AFIP. Cerebral intraventricular neoplasms: radiologic-pathologic correlation. Radiographics. 22(6):1473-505, 2002
                                                19. Sunada I et al: 18F-FDG and 11C-methionine PET in choroid plexus papilloma--report of three cases. Radiat Med. 20(2):97-100, 2002
                                                20. Levy ML et al: Choroid plexus tumors in children: significance of stromal invasion. Neurosurgery. 48(2):303-9, 2001
                                                Related Anatomy
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                                                Related Differential Diagnoses
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                                                References
                                                Tables

                                                Tables

                                                KEY FACTS

                                                • Terminology

                                                  • Imaging

                                                    • Top Differential Diagnoses

                                                      • Pathology

                                                        • Clinical Issues

                                                          • Diagnostic Checklist

                                                            TERMINOLOGY

                                                            • Abbreviations

                                                              • Choroid plexus tumor (CPT)
                                                                • Choroid plexus papilloma (CPP): WHO grade 1
                                                                • Atypical choroid plexus papilloma (aCPP): WHO grade 2
                                                                • Choroid plexus carcinoma (CPCa): WHO grade 3
                                                            • Definitions

                                                              • Intraventricular, papillary neoplasm of CP epithelium

                                                            IMAGING

                                                            • General Features

                                                              • CT Findings

                                                                • MR Findings

                                                                  • Ultrasonographic Findings

                                                                    • Angiographic Findings

                                                                      • Nuclear Medicine Findings

                                                                        • Imaging Recommendations

                                                                          DIFFERENTIAL DIAGNOSIS

                                                                            PATHOLOGY

                                                                            • General Features

                                                                              • Staging, Grading, & Classification

                                                                                • Gross Pathologic & Surgical Features

                                                                                  • Microscopic Features

                                                                                    CLINICAL ISSUES

                                                                                    • Presentation

                                                                                      • Demographics

                                                                                        • Natural History & Prognosis

                                                                                          • Treatment

                                                                                            DIAGNOSTIC CHECKLIST

                                                                                            • Consider

                                                                                              Selected References

                                                                                              1. Trybula SJ et al: Infratentorial choroid plexus tumors in children. Childs Nerv Syst. 36(8):1761-6, 2020
                                                                                              2. Crawford JR et al: Perinatal (fetal and neonatal) choroid plexus tumors: a review. Childs Nerv Syst. 35(6):937-44, 2019
                                                                                              3. Dash C et al: Management of choroid plexus tumors in infants and young children up to 4 years of age: an institutional experience. World Neurosurg. 121:e237-45, 2019
                                                                                              4. Sasaki T et al: Roles of the apparent diffusion coefficient and tumor volume in predicting tumor grade in patients with choroid plexus tumors. Neuroradiology. 60(5):479-86, 2018
                                                                                              5. Zhou WJ et al: Clinical features and prognostic risk factors of choroid plexus tumors in children. Chin Med J (Engl). 131(24):2938-46, 2018
                                                                                              6. Siegfried A et al: A French retrospective study on clinical outcome in 102 choroid plexus tumors in children. J Neurooncol. 135(1):151-60, 2017
                                                                                              7. Thomas C et al: Methylation profiling of choroid plexus tumors reveals 3 clinically distinct subgroups. Neuro Oncol. 18(6):790-6, 2016
                                                                                              8. Dangouloff-Ros V et al: Choroid plexus neoplasms: toward a distinction between carcinoma and papilloma using arterial spin-labeling. AJNR Am J Neuroradiol. 36(9):1786-90, 2015
                                                                                              9. Dudley RW et al: Pediatric choroid plexus tumors: epidemiology, treatments, and outcome analysis on 202 children from the SEER database. J Neurooncol. 121(1):201-7, 2015
                                                                                              10. Merino DM et al: Molecular characterization of choroid plexus tumors reveals novel clinically relevant subgroups. Clin Cancer Res. 21(1):184-92, 2015
                                                                                              11. Jaiswal S et al: Choroid plexus tumors: a clinico-pathological and neuro-radiological study of 23 cases. Asian J Neurosurg. 8(1):29-35, 2013
                                                                                              12. Lam S et al: Choroid plexus tumors in children: a population-based study. Pediatr Neurosurg. 49(6):331-8, 2013
                                                                                              13. Yan C et al: Choroid plexus tumours: classification, MR imaging findings and pathological correlation. J Med Imaging Radiat Oncol. 57(2):176-83, 2013
                                                                                              14. Lafay-Cousin L et al: Choroid plexus tumors in children less than 36 months: the Canadian Pediatric Brain Tumor Consortium (CPBTC) experience. Childs Nerv Syst. 27(2):259-64, 2011
                                                                                              15. Krieger MD et al: Differentiation of choroid plexus tumors by advanced magnetic resonance spectroscopy. Neurosurg Focus. 18(6A):E4, 2005
                                                                                              16. Fujimura M et al: Hydrocephalus due to cerebrospinal fluid overproduction by bilateral choroid plexus papillomas. Childs Nerv Syst. 20(7):485-8, 2004
                                                                                              17. Meyers SP et al: Choroid plexus carcinomas in children: MRI features and patient outcomes. Neuroradiology. 46(9):770-80, 2004
                                                                                              18. Koeller KK et al: From the archives of the AFIP. Cerebral intraventricular neoplasms: radiologic-pathologic correlation. Radiographics. 22(6):1473-505, 2002
                                                                                              19. Sunada I et al: 18F-FDG and 11C-methionine PET in choroid plexus papilloma--report of three cases. Radiat Med. 20(2):97-100, 2002
                                                                                              20. Levy ML et al: Choroid plexus tumors in children: significance of stromal invasion. Neurosurgery. 48(2):303-9, 2001