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Pediatrics
Diagnosis
Gastrointestinal
Abnormalities in Immunocompromised Children
Chronic Granulomatous Disease in Childhood
Chronic Granulomatous Disease in Childhood
Alexander J. Towbin, MD
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KEY FACTS

  • Terminology

    • Imaging

      • Pathology

        • Clinical Issues

          TERMINOLOGY

          • Abbreviations

            • Chronic granulomatous disease (CGD)

          • Definitions

            • Primary immunodeficiency characterized by recurrent infections at epithelial surfaces & organs with large numbers of reticuloendothelial cells

          IMAGING

          • General Features

            • Radiographic Findings

              • Fluoroscopic Findings

                • CT Findings

                  • MR Findings

                    • Ultrasonographic Findings

                      • Imaging Recommendations

                        DIFFERENTIAL DIAGNOSIS

                          PATHOLOGY

                          • General Features

                            CLINICAL ISSUES

                            • Presentation

                              • Demographics

                                • Natural History & Prognosis

                                  • Treatment

                                    DIAGNOSTIC CHECKLIST

                                    • Consider

                                      Selected References

                                      1. Khangura SK et al: Gastrointestinal features of chronic granulomatous disease found during endoscopy. Clin Gastroenterol Hepatol. 14(3):395-402.e5, 2016
                                      2. Bortoletto P et al: Chronic granulomatous disease: a large, single-center US experience. Pediatr Infect Dis J. 34(10):1110-4, 2015
                                      3. Chiriaco M et al: Chronic granulomatous disease: clinical, molecular and therapeutic aspects. Pediatr Allergy Immunol. ePub, 2015
                                      4. Marciano BE et al: Common severe infections in chronic granulomatous disease. Clin Infect Dis. 60(8):1176-83, 2015
                                      5. Towbin AJ et al: Chronic granulomatous disease. Pediatr Radiol. 40(5):657-68; quiz 792-3, 2010
                                      6. Errante PR et al: The use of interferon-gamma therapy in chronic granulomatous disease. Recent Pat Antiinfect Drug Discov. 3(3):225-30, 2008
                                      7. Khanna G et al: Imaging of chronic granulomatous disease in children. Radiographics. 25(5):1183-95, 2005
                                      Related Anatomy
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                                      Related Differential Diagnoses
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                                      References
                                      Tables

                                      Tables

                                      KEY FACTS

                                      • Terminology

                                        • Imaging

                                          • Pathology

                                            • Clinical Issues

                                              TERMINOLOGY

                                              • Abbreviations

                                                • Chronic granulomatous disease (CGD)

                                              • Definitions

                                                • Primary immunodeficiency characterized by recurrent infections at epithelial surfaces & organs with large numbers of reticuloendothelial cells

                                              IMAGING

                                              • General Features

                                                • Radiographic Findings

                                                  • Fluoroscopic Findings

                                                    • CT Findings

                                                      • MR Findings

                                                        • Ultrasonographic Findings

                                                          • Imaging Recommendations

                                                            DIFFERENTIAL DIAGNOSIS

                                                              PATHOLOGY

                                                              • General Features

                                                                CLINICAL ISSUES

                                                                • Presentation

                                                                  • Demographics

                                                                    • Natural History & Prognosis

                                                                      • Treatment

                                                                        DIAGNOSTIC CHECKLIST

                                                                        • Consider

                                                                          Selected References

                                                                          1. Khangura SK et al: Gastrointestinal features of chronic granulomatous disease found during endoscopy. Clin Gastroenterol Hepatol. 14(3):395-402.e5, 2016
                                                                          2. Bortoletto P et al: Chronic granulomatous disease: a large, single-center US experience. Pediatr Infect Dis J. 34(10):1110-4, 2015
                                                                          3. Chiriaco M et al: Chronic granulomatous disease: clinical, molecular and therapeutic aspects. Pediatr Allergy Immunol. ePub, 2015
                                                                          4. Marciano BE et al: Common severe infections in chronic granulomatous disease. Clin Infect Dis. 60(8):1176-83, 2015
                                                                          5. Towbin AJ et al: Chronic granulomatous disease. Pediatr Radiol. 40(5):657-68; quiz 792-3, 2010
                                                                          6. Errante PR et al: The use of interferon-gamma therapy in chronic granulomatous disease. Recent Pat Antiinfect Drug Discov. 3(3):225-30, 2008
                                                                          7. Khanna G et al: Imaging of chronic granulomatous disease in children. Radiographics. 25(5):1183-95, 2005