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Chronic Granulomatous Disease
Carlos S. Restrepo, MD
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KEY FACTS

  • Terminology

    • Imaging

      • Top Differential Diagnoses

        • Pathology

          • Clinical Issues

            TERMINOLOGY

            • Abbreviations

              • Chronic granulomatous disease (CGD)
            • Definitions

              • Heterogeneous group of rare genetic disorders that result in recurrent, life-threatening bacterial and fungal infections and granuloma formation
              • Defective phagocytic function
                • Secondary to abnormal nicotinamide adenine dinucleotide phosphatase (NADPH) oxidase
                • Inability to generate free radical superoxide
                  • Normal phagocytes contain and destroy certain bacterial and fungal microorganisms

            IMAGING

            • Radiographic Findings

              • CT Findings

                DIFFERENTIAL DIAGNOSIS

                  PATHOLOGY

                  • General Features

                    CLINICAL ISSUES

                    • Presentation

                      • Demographics

                        • Natural History & Prognosis

                          • Treatment

                            Selected References

                            1. Salvator H et al: Pulmonary manifestations in adult patients with chronic granulomatous disease. Eur Respir J. 45(6):1613-23, 2015
                            2. Mahdaviani SA et al: Pulmonary manifestations of chronic granulomatous disease. Expert Rev Clin Immunol. 9(2):153-60, 2013
                            3. Åhlin A et al: Chronic granulomatous disease-haematopoietic stem cell transplantation versus conventional treatment. Acta Paediatr. 102(11):1087-94, 2013
                            4. Song E et al: Chronic granulomatous disease: a review of the infectious and inflammatory complications. Clin Mol Allergy. 9(1):10, 2011
                            5. Holland SM: Chronic granulomatous disease. Clin Rev Allergy Immunol. 38(1):3-10, 2010
                            6. Godoy MC et al: Chest radiographic and CT manifestations of chronic granulomatous disease in adults. AJR Am J Roentgenol. 191(5):1570-5, 2008
                            7. Khanna G et al: Imaging of chronic granulomatous disease in children. Radiographics. 25(5):1183-95, 2005
                            Related Anatomy
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                            Related Differential Diagnoses
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                            References
                            Tables

                            Tables

                            KEY FACTS

                            • Terminology

                              • Imaging

                                • Top Differential Diagnoses

                                  • Pathology

                                    • Clinical Issues

                                      TERMINOLOGY

                                      • Abbreviations

                                        • Chronic granulomatous disease (CGD)
                                      • Definitions

                                        • Heterogeneous group of rare genetic disorders that result in recurrent, life-threatening bacterial and fungal infections and granuloma formation
                                        • Defective phagocytic function
                                          • Secondary to abnormal nicotinamide adenine dinucleotide phosphatase (NADPH) oxidase
                                          • Inability to generate free radical superoxide
                                            • Normal phagocytes contain and destroy certain bacterial and fungal microorganisms

                                      IMAGING

                                      • Radiographic Findings

                                        • CT Findings

                                          DIFFERENTIAL DIAGNOSIS

                                            PATHOLOGY

                                            • General Features

                                              CLINICAL ISSUES

                                              • Presentation

                                                • Demographics

                                                  • Natural History & Prognosis

                                                    • Treatment

                                                      Selected References

                                                      1. Salvator H et al: Pulmonary manifestations in adult patients with chronic granulomatous disease. Eur Respir J. 45(6):1613-23, 2015
                                                      2. Mahdaviani SA et al: Pulmonary manifestations of chronic granulomatous disease. Expert Rev Clin Immunol. 9(2):153-60, 2013
                                                      3. Åhlin A et al: Chronic granulomatous disease-haematopoietic stem cell transplantation versus conventional treatment. Acta Paediatr. 102(11):1087-94, 2013
                                                      4. Song E et al: Chronic granulomatous disease: a review of the infectious and inflammatory complications. Clin Mol Allergy. 9(1):10, 2011
                                                      5. Holland SM: Chronic granulomatous disease. Clin Rev Allergy Immunol. 38(1):3-10, 2010
                                                      6. Godoy MC et al: Chest radiographic and CT manifestations of chronic granulomatous disease in adults. AJR Am J Roentgenol. 191(5):1570-5, 2008
                                                      7. Khanna G et al: Imaging of chronic granulomatous disease in children. Radiographics. 25(5):1183-95, 2005