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Chronic Lymphocytic Leukemia
Terrance Healey, MD
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KEY FACTS

  • Terminology

    • Imaging

      • Top Differential Diagnoses

        • Pathology

          • Clinical Issues

            • Diagnostic Checklist

              TERMINOLOGY

              • Abbreviations

                • Chronic lymphocytic leukemia (CLL)
              • Definitions

                • Lymphadenopathy, organomegaly, and infiltrating monoclonal B cells
                • Small lymphocytic lymphoma (SLL): Same as CLL with identical immunophenotype and histopathology but lacks peripheral lymphocytosis

              IMAGING

              • General Features

                • Radiographic Findings

                  • CT Findings

                    • MR Findings

                      • Imaging Recommendations

                        • Nuclear Medicine Findings

                          DIFFERENTIAL DIAGNOSIS

                            PATHOLOGY

                            • General Features

                              • Staging, Grading, & Classification

                                • Microscopic Features

                                  CLINICAL ISSUES

                                  • Presentation

                                    • Demographics

                                      • Natural History & Prognosis

                                        • Treatment

                                          DIAGNOSTIC CHECKLIST

                                          • Consider

                                            Selected References

                                            1. Mauro FR et al: Diagnostic and prognostic role of PET/CT in patients with chronic lymphocytic leukemia and progressive disease. Leukemia. ePub, 2015
                                            2. Fiz F et al: Adult advanced chronic lymphocytic leukemia: computational analysis of whole-body CT documents a bone structure alteration. Radiology. 271(3):805-13, 2014
                                            3. Gentile M et al: Total body computed tomography scan in the initial work-up of Binet stage A chronic lymphocytic leukemia patients: Results of the prospective, multicenter O-CLL1-GISL study. Am J Hematol. 88(7):539-44, 2013
                                            4. Landau DA et al: Chronic lymphocytic leukemia: molecular heterogeneity revealed by high-throughput genomics. Genome Med. 5(5):47, 2013
                                            5. Hill BT et al: Pulmonary involvement by chronic lymphocytic leukemia/small lymphocytic lymphoma is a specific pathologic finding independent of inflammatory infiltration. Leuk Lymphoma. 53(4):589-95, 2012
                                            6. Santos FP et al: Small lymphocytic lymphoma and chronic lymphocytic leukemia: are they the same disease? Cancer J. 18(5):396-403, 2012
                                            7. Moreno C et al: Autoimmune cytopenia in chronic lymphocytic leukemia: prevalence, clinical associations, and prognostic significance. Blood. 116(23):4771-6, 2010
                                            8. Tsimberidou AM et al: Assessment of chronic lymphocytic leukemia and small lymphocytic lymphoma by absolute lymphocyte counts in 2,126 patients: 20 years of experience at the University of Texas M.D. Anderson Cancer Center. J Clin Oncol. 25(29):4648-56, 2007
                                            Related Anatomy
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                                            Related Differential Diagnoses
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                                            References
                                            Tables

                                            Tables

                                            KEY FACTS

                                            • Terminology

                                              • Imaging

                                                • Top Differential Diagnoses

                                                  • Pathology

                                                    • Clinical Issues

                                                      • Diagnostic Checklist

                                                        TERMINOLOGY

                                                        • Abbreviations

                                                          • Chronic lymphocytic leukemia (CLL)
                                                        • Definitions

                                                          • Lymphadenopathy, organomegaly, and infiltrating monoclonal B cells
                                                          • Small lymphocytic lymphoma (SLL): Same as CLL with identical immunophenotype and histopathology but lacks peripheral lymphocytosis

                                                        IMAGING

                                                        • General Features

                                                          • Radiographic Findings

                                                            • CT Findings

                                                              • MR Findings

                                                                • Imaging Recommendations

                                                                  • Nuclear Medicine Findings

                                                                    DIFFERENTIAL DIAGNOSIS

                                                                      PATHOLOGY

                                                                      • General Features

                                                                        • Staging, Grading, & Classification

                                                                          • Microscopic Features

                                                                            CLINICAL ISSUES

                                                                            • Presentation

                                                                              • Demographics

                                                                                • Natural History & Prognosis

                                                                                  • Treatment

                                                                                    DIAGNOSTIC CHECKLIST

                                                                                    • Consider

                                                                                      Selected References

                                                                                      1. Mauro FR et al: Diagnostic and prognostic role of PET/CT in patients with chronic lymphocytic leukemia and progressive disease. Leukemia. ePub, 2015
                                                                                      2. Fiz F et al: Adult advanced chronic lymphocytic leukemia: computational analysis of whole-body CT documents a bone structure alteration. Radiology. 271(3):805-13, 2014
                                                                                      3. Gentile M et al: Total body computed tomography scan in the initial work-up of Binet stage A chronic lymphocytic leukemia patients: Results of the prospective, multicenter O-CLL1-GISL study. Am J Hematol. 88(7):539-44, 2013
                                                                                      4. Landau DA et al: Chronic lymphocytic leukemia: molecular heterogeneity revealed by high-throughput genomics. Genome Med. 5(5):47, 2013
                                                                                      5. Hill BT et al: Pulmonary involvement by chronic lymphocytic leukemia/small lymphocytic lymphoma is a specific pathologic finding independent of inflammatory infiltration. Leuk Lymphoma. 53(4):589-95, 2012
                                                                                      6. Santos FP et al: Small lymphocytic lymphoma and chronic lymphocytic leukemia: are they the same disease? Cancer J. 18(5):396-403, 2012
                                                                                      7. Moreno C et al: Autoimmune cytopenia in chronic lymphocytic leukemia: prevalence, clinical associations, and prognostic significance. Blood. 116(23):4771-6, 2010
                                                                                      8. Tsimberidou AM et al: Assessment of chronic lymphocytic leukemia and small lymphocytic lymphoma by absolute lymphocyte counts in 2,126 patients: 20 years of experience at the University of Texas M.D. Anderson Cancer Center. J Clin Oncol. 25(29):4648-56, 2007