Autosomal recessive syndromic form of disease is Majeed syndrome (OMIM# 609628)
Definitions
Autoinflammatory disorder of bone with fever, multifocal painful nonpyogenic bone lesions, relapsing and remitting course in children and adolescents
Adult disease is SAPHO syndrome (synovitis, acne, pustulosis, hyperostosis, osteitis)
Sterile inflammation of bone is hallmark feature
IMAGING
General Features
Radiographic Findings
MR Findings
DIFFERENTIAL DIAGNOSIS
PATHOLOGY
General Features
Staging, Grading, & Classification
CLINICAL ISSUES
Presentation
Demographics
Natural History & Prognosis
Treatment
DIAGNOSTIC CHECKLIST
Consider
Selected References
Oligbu G et al: The dilemma of chronic recurrent multifocal osteomyelitis. Reumatol Clin. ePub, 2019
Jurik AG et al: SAPHO and CRMO: the value of imaging. Semin Musculoskelet Radiol. 22(2):207-24, 2018
Hofmann SR et al: Chronic recurrent multifocal osteomyelitis (CRMO): presentation, pathogenesis, and treatment. Curr Osteoporos Rep. 15(6):542-54, 2017
Roderick MR et al: Chronic recurrent multifocal osteomyelitis (CRMO) - advancing the diagnosis. Pediatr Rheumatol Online J. 14(1):47, 2016
Hedrich CM et al: Autoinflammatory bone disorders with special focus on chronic recurrent multifocal osteomyelitis (CRMO). Pediatr Rheumatol Online J. 11(1):47, 2013
Fritz J et al: Chronic recurrent multifocal osteomyelitis: comparison of whole-body MR imaging with radiography and correlation with clinical and laboratory data. Radiology. 252(3):842-51, 2009
Khanna G et al: Imaging of chronic recurrent multifocal osteomyelitis. Radiographics. 29(4):1159-77, 2009
Catalano-Pons C et al: Clinical outcome in children with chronic recurrent multifocal osteomyelitis. Rheumatology (Oxford). 47(9):1397-9, 2008
Gleeson H et al: Childhood chronic recurrent multifocal osteomyelitis: pamidronate therapy decreases pain and improves vertebral shape. J Rheumatol. 35(4):707-12, 2008
Hobolth L et al: Chronic recurrent multifocal osteomyelitis demonstrated by Tc-99m methylene diphosphonate bone scan. Clin Nucl Med. 33(1):61-3, 2008
Moll C et al: Ilium osteitis as the main manifestation of the SAPHO syndrome: response to infliximab therapy and review of the literature. Semin Arthritis Rheum. 37(5):299-306, 2008
Buck FM et al: Chronic recurrent multifocal osteomyelitis (CRMO) with symmetric involvement of both femora: X-ray, bone scintigram, and MR imaging findings in one case. J Magn Reson Imaging. 26(2):422-6, 2007
El-Shanti HI et al: Chronic recurrent multifocal osteomyelitis: a concise review and genetic update. Clin Orthop Relat Res. 462:11-9, 2007
Ferguson PJ et al: Autoinflammatory bone disorders. Curr Opin Rheumatol. 19(5):492-8, 2007
Autosomal recessive syndromic form of disease is Majeed syndrome (OMIM# 609628)
Definitions
Autoinflammatory disorder of bone with fever, multifocal painful nonpyogenic bone lesions, relapsing and remitting course in children and adolescents
Adult disease is SAPHO syndrome (synovitis, acne, pustulosis, hyperostosis, osteitis)
Sterile inflammation of bone is hallmark feature
IMAGING
General Features
Radiographic Findings
MR Findings
DIFFERENTIAL DIAGNOSIS
PATHOLOGY
General Features
Staging, Grading, & Classification
CLINICAL ISSUES
Presentation
Demographics
Natural History & Prognosis
Treatment
DIAGNOSTIC CHECKLIST
Consider
Selected References
Oligbu G et al: The dilemma of chronic recurrent multifocal osteomyelitis. Reumatol Clin. ePub, 2019
Jurik AG et al: SAPHO and CRMO: the value of imaging. Semin Musculoskelet Radiol. 22(2):207-24, 2018
Hofmann SR et al: Chronic recurrent multifocal osteomyelitis (CRMO): presentation, pathogenesis, and treatment. Curr Osteoporos Rep. 15(6):542-54, 2017
Roderick MR et al: Chronic recurrent multifocal osteomyelitis (CRMO) - advancing the diagnosis. Pediatr Rheumatol Online J. 14(1):47, 2016
Hedrich CM et al: Autoinflammatory bone disorders with special focus on chronic recurrent multifocal osteomyelitis (CRMO). Pediatr Rheumatol Online J. 11(1):47, 2013
Fritz J et al: Chronic recurrent multifocal osteomyelitis: comparison of whole-body MR imaging with radiography and correlation with clinical and laboratory data. Radiology. 252(3):842-51, 2009
Khanna G et al: Imaging of chronic recurrent multifocal osteomyelitis. Radiographics. 29(4):1159-77, 2009
Catalano-Pons C et al: Clinical outcome in children with chronic recurrent multifocal osteomyelitis. Rheumatology (Oxford). 47(9):1397-9, 2008
Gleeson H et al: Childhood chronic recurrent multifocal osteomyelitis: pamidronate therapy decreases pain and improves vertebral shape. J Rheumatol. 35(4):707-12, 2008
Hobolth L et al: Chronic recurrent multifocal osteomyelitis demonstrated by Tc-99m methylene diphosphonate bone scan. Clin Nucl Med. 33(1):61-3, 2008
Moll C et al: Ilium osteitis as the main manifestation of the SAPHO syndrome: response to infliximab therapy and review of the literature. Semin Arthritis Rheum. 37(5):299-306, 2008
Buck FM et al: Chronic recurrent multifocal osteomyelitis (CRMO) with symmetric involvement of both femora: X-ray, bone scintigram, and MR imaging findings in one case. J Magn Reson Imaging. 26(2):422-6, 2007
El-Shanti HI et al: Chronic recurrent multifocal osteomyelitis: a concise review and genetic update. Clin Orthop Relat Res. 462:11-9, 2007
Ferguson PJ et al: Autoinflammatory bone disorders. Curr Opin Rheumatol. 19(5):492-8, 2007
STATdx includes over 200,000 searchable images, including x-ray, CT, MR, and ultrasound images. To access all images, please log in or subscribe.