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KEY FACTS
Terminology
Imaging
Top Differential Diagnoses
Pathology
Clinical Issues
Diagnostic Checklist
TERMINOLOGY
Abbreviations
- Chronic traumatic encephalopathy (CTE)
Synonyms
- "Punch-drunk" syndrome/dementia pugilistica
- Old terms originally applied to boxer's dementia
- Leg weakness, vertigo, gait difficulties, episodes of confusion, later parkinsonism & dementia
- "Punch-drunk" syndrome/dementia pugilistica
Definitions
- Neurodegenerative disease induced by repetitive concussive/subconcussive traumatic brain injuries (TBI)
- CTE classically defined secondary to repetitive TBI
- Postmortem studies also suggest single TBI as cause
- Currently diagnosis by postmortem neuropathological examination based on specific pattern of tau deposition
- Neurodegenerative disease induced by repetitive concussive/subconcussive traumatic brain injuries (TBI)
IMAGING
General Features
CT Findings
MR Findings
Nuclear Medicine Findings
Imaging Recommendations
DIFFERENTIAL DIAGNOSIS
PATHOLOGY
General Features
Staging, Grading, & Classification
Gross Pathologic & Surgical Features
Microscopic Features
CLINICAL ISSUES
Presentation
Treatment
DIAGNOSTIC CHECKLIST
Reporting Tips
Selected References
- Falcon B et al: Novel tau filament fold in chronic traumatic encephalopathy encloses hydrophobic molecules. Nature. 568(7752):420-3, 2019
- Ruprecht R et al: Systematic review on the characterization of chronic traumatic encephalopathy by MRI and MRS. J Magn Reson Imaging. 49(1):212-28, 2019
- Stern RA et al: Tau positron-emission tomography in former National Football League players. N Engl J Med. 380(18):1716-25, 2019
- Sparks P et al: Neuroimaging in the diagnosis of chronic traumatic encephalopathy: a systematic review. Clin J Sport Med. ePub, 2017
- Shetty T et al: Imaging in chronic traumatic encephalopathy and traumatic brain injury. Sports Health. 8(1):26-36, 2016
- Bramlett H et al: Long-term consequences of traumatic brain injury: current status of potential mechanisms of injury and neurologic outcomes. J Neurotrauma. 32(23):1834-48, 2015
- Esopenko C et al: Aging, neurodegenerative disease and traumatic brain injury: the role of neuroimaging. J Neurotrauma. 32(4):209-20, 2015
- Stein TD et al: Beta-amyloid deposition in chronic traumatic encephalopathy. Acta Neuropathol. 130(1):21-34, 2015
- Aungst SL et al: Repeated mild traumatic brain injury causes chronic neuroinflammation, changes in hippocampal synaptic plasticity, and associated cognitive deficits. J Cereb Blood Flow Metab. 34(7):1223-32, 2014
- Gandy S et al: Chronic traumatic encephalopathy: clinical-biomarker correlations and current concepts in pathogenesis. Mol Neurodegener. 9:37, 2014
- Saigal R et al: The long-term effects of repetitive mild head injuries in sports. Neurosurgery. 75 Suppl 4:S149-55, 2014
- Sundman MH et al: Examining the relationship between head trauma and neurodegenerative disease: a review of epidemiology, pathology and neuroimaging techniques. J Alzheimers Dis Parkinsonism. 4, 2014
- Johnson VE et al: Widespread τ and amyloid-β pathology many years after a single traumatic brain injury in humans. Brain Pathol. 22(2):142-9, 2012
Related Anatomy
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Related Differential Diagnoses
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References
Tables
Tables
KEY FACTS
Terminology
Imaging
Top Differential Diagnoses
Pathology
Clinical Issues
Diagnostic Checklist
TERMINOLOGY
Abbreviations
- Chronic traumatic encephalopathy (CTE)
Synonyms
- "Punch-drunk" syndrome/dementia pugilistica
- Old terms originally applied to boxer's dementia
- Leg weakness, vertigo, gait difficulties, episodes of confusion, later parkinsonism & dementia
- "Punch-drunk" syndrome/dementia pugilistica
Definitions
- Neurodegenerative disease induced by repetitive concussive/subconcussive traumatic brain injuries (TBI)
- CTE classically defined secondary to repetitive TBI
- Postmortem studies also suggest single TBI as cause
- Currently diagnosis by postmortem neuropathological examination based on specific pattern of tau deposition
- Neurodegenerative disease induced by repetitive concussive/subconcussive traumatic brain injuries (TBI)
IMAGING
General Features
CT Findings
MR Findings
Nuclear Medicine Findings
Imaging Recommendations
DIFFERENTIAL DIAGNOSIS
PATHOLOGY
General Features
Staging, Grading, & Classification
Gross Pathologic & Surgical Features
Microscopic Features
CLINICAL ISSUES
Presentation
Treatment
DIAGNOSTIC CHECKLIST
Reporting Tips
Selected References
- Falcon B et al: Novel tau filament fold in chronic traumatic encephalopathy encloses hydrophobic molecules. Nature. 568(7752):420-3, 2019
- Ruprecht R et al: Systematic review on the characterization of chronic traumatic encephalopathy by MRI and MRS. J Magn Reson Imaging. 49(1):212-28, 2019
- Stern RA et al: Tau positron-emission tomography in former National Football League players. N Engl J Med. 380(18):1716-25, 2019
- Sparks P et al: Neuroimaging in the diagnosis of chronic traumatic encephalopathy: a systematic review. Clin J Sport Med. ePub, 2017
- Shetty T et al: Imaging in chronic traumatic encephalopathy and traumatic brain injury. Sports Health. 8(1):26-36, 2016
- Bramlett H et al: Long-term consequences of traumatic brain injury: current status of potential mechanisms of injury and neurologic outcomes. J Neurotrauma. 32(23):1834-48, 2015
- Esopenko C et al: Aging, neurodegenerative disease and traumatic brain injury: the role of neuroimaging. J Neurotrauma. 32(4):209-20, 2015
- Stein TD et al: Beta-amyloid deposition in chronic traumatic encephalopathy. Acta Neuropathol. 130(1):21-34, 2015
- Aungst SL et al: Repeated mild traumatic brain injury causes chronic neuroinflammation, changes in hippocampal synaptic plasticity, and associated cognitive deficits. J Cereb Blood Flow Metab. 34(7):1223-32, 2014
- Gandy S et al: Chronic traumatic encephalopathy: clinical-biomarker correlations and current concepts in pathogenesis. Mol Neurodegener. 9:37, 2014
- Saigal R et al: The long-term effects of repetitive mild head injuries in sports. Neurosurgery. 75 Suppl 4:S149-55, 2014
- Sundman MH et al: Examining the relationship between head trauma and neurodegenerative disease: a review of epidemiology, pathology and neuroimaging techniques. J Alzheimers Dis Parkinsonism. 4, 2014
- Johnson VE et al: Widespread τ and amyloid-β pathology many years after a single traumatic brain injury in humans. Brain Pathol. 22(2):142-9, 2012
