link
Bookmarks
Cirrhosis
Atif Zaheer, MD
To access 4,300 diagnoses written by the world's leading experts in radiology, please log in or subscribe.Subscribe
0
73
2
16

KEY FACTS

  • Terminology

    • Imaging

      • Top Differential Diagnoses

        • Diagnostic Checklist

          TERMINOLOGY

          • Definitions

            • Chronic liver disease characterized by diffuse parenchymal injury, extensive fibrosis, & conversion of liver architecture into structurally abnormal nodules

          IMAGING

          • General Features

            • CT Findings

              • MR Findings

                • Ultrasonographic Findings

                  • Imaging Recommendations

                    DIFFERENTIAL DIAGNOSIS

                      PATHOLOGY

                      • General Features

                        • Staging, Grading, & Classification

                          • Gross Pathologic & Surgical Features

                            • Microscopic Features

                              CLINICAL ISSUES

                              • Presentation

                                • Demographics

                                  • Natural History & Prognosis

                                    • Treatment

                                      DIAGNOSTIC CHECKLIST

                                      • Consider

                                        • Image Interpretation Pearls

                                          • Reporting Tips

                                            Selected References

                                            1. Ajmera VH et al: Clinical utility of an increase in magnetic resonance elastography in predicting fibrosis progression in nonalcoholic fatty liver disease. Hepatology. 71(3):849-60, 2020
                                            2. Cannella R et al: Liver Imaging Reporting and Data System (LI-RADS) v2018: diagnostic value of ancillary features favoring malignancy in hypervascular observations ≥10 mm at intermediate (LR-3) and high probability (LR-4) for hepatocellular carcinoma. Eur Radiol. 30(7):3770-81, 2020
                                            3. Khalifa A et al: Lower gastrointestinal bleeding in patients with cirrhosis-etiology and outcomes. Am J Med Sci. 359(4):206-11, 2020
                                            4. Kim SS et al: Value of gadoxetic acid-enhanced MRI and diffusion-weighted imaging in the differentiation of hypervascular hyperplastic nodule from small (<3 cm) hypervascular hepatocellular carcinoma in patients with alcoholic liver cirrhosis: A retrospective case-control study. J Magn Reson Imaging. 51(1):70-80, 2020
                                            5. Lashen SA et al: Liver stiffness as a predictor of hepatocellular carcinoma behavior in patients with hepatitis C related liver cirrhosis. Hepatobiliary Pancreat Dis Int. 19(1):22-8, 2020
                                            6. Møller S et al: Pathophysiological-based treatments of complications of cirrhosis. Scand J Gastroenterol. 1-12, 2020
                                            7. Semaan S et al: Hepatocellular carcinoma detection in liver cirrhosis: diagnostic performance of contrast-enhanced CT vs. MRI with extracellular contrast vs. gadoxetic acid. Eur Radiol. 30(2):1020-30, 2020
                                            8. Singh R et al: Accuracy of liver and spleen stiffness on magnetic resonance elastography for detecting portal hypertension: a systematic review and meta-analysis. Eur J Gastroenterol Hepatol. ePub, 2020
                                            9. Zhang YN et al: Liver fibrosis imaging: a clinical review of ultrasound and magnetic resonance elastography. J Magn Reson Imaging. 51(1):25-42, 2020
                                            10. Guglielmo FF et al: Liver MR elastography technique and image interpretation: pearls and pitfalls. Radiographics. 39(7):1983-2002, 2019
                                            11. Kozaka K et al: Doughnut-like hyperintense nodules on hepatobiliary phase without arterial-phase hyperenhancement in cirrhotic liver: imaging and clinicopathological features. Eur Radiol. 29(12):6489-98, 2019
                                            12. Rodgers SK et al: Role of US LI-RADS in the LI-RADS algorithm. Radiographics. 39(3):690-708, 2019
                                            13. Schwope RB et al: The many faces of cirrhosis. Abdom Radiol (NY). 45(10): 3065-80, 2019
                                            14. Barnett R: Liver cirrhosis. Lancet. 392(10144):275, 2018
                                            15. Elsayes KM et al: Spectrum of pitfalls, pseudolesions, and potential misdiagnoses in cirrhosis. AJR Am J Roentgenol. 211(1):87-96, 2018
                                            16. Inchingolo R et al: MR with Gd-EOB-DTPA in assessment of liver nodules in cirrhotic patients. World J Hepatol. 10(7):462-73, 2018
                                            17. Poullos PD et al: Structured reporting of multiphasic CT for hepatocellular carcinoma: effect on staging and suitability for transplant. AJR Am J Roentgenol. 210(4):766-74, 2018
                                            18. Cho HJ et al: Development of risk prediction model for hepatocellular carcinoma progression of indeterminate nodules in hepatitis B virus-related cirrhotic liver. Am J Gastroenterol. 112(3):460-70, 2017
                                            19. Petitclerc L et al: Liver fibrosis: review of current imaging and MRI quantification techniques. J Magn Reson Imaging. 45(5):1276-95, 2017
                                            20. Li RK et al: Detection of endogenous iron reduction during hepatocarcinogenesis at susceptibility-weighted MR imaging: value for characterization of hepatocellular carcinoma and dysplastic nodule in cirrhotic liver. PLoS One. 10(11):e0142882, 2015
                                            21. Beland MD et al: A pilot study estimating liver fibrosis with ultrasound shear-wave elastography: does the cause of liver disease or location of measurement affect performance? AJR Am J Roentgenol. 203(3):W267-73, 2014
                                            22. Jha RC et al: LI-RADS categorization of benign and likely benign findings in patients at risk of hepatocellular carcinoma: a pictorial atlas. AJR Am J Roentgenol. 203(1):W48-69, 2014
                                            23. Khalili K et al: Indeterminate 1-2-cm nodules found on hepatocellular carcinoma surveillance: biopsy for all, some, or none? Hepatology. 54(6):2048-54, 2011
                                            24. Vivarelli M et al: Liver transplantation for hepatocellular carcinoma on cirrhosis: strategies to avoid tumor recurrence. World J Gastroenterol. 17(43):4741-6, 2011
                                            25. European Association for the Study of the Liver: EASL clinical practice guidelines on the management of ascites, spontaneous bacterial peritonitis, and hepatorenal syndrome in cirrhosis. J Hepatol. 53(3):397-417, 2010
                                            26. Boll DT et al: Diffuse liver disease: strategies for hepatic CT and MR imaging. Radiographics. 29(6):1591-614, 2009
                                            Related Anatomy
                                            Loading...
                                            Related Differential Diagnoses
                                            Loading...
                                            References
                                            Tables

                                            Tables

                                            KEY FACTS

                                            • Terminology

                                              • Imaging

                                                • Top Differential Diagnoses

                                                  • Diagnostic Checklist

                                                    TERMINOLOGY

                                                    • Definitions

                                                      • Chronic liver disease characterized by diffuse parenchymal injury, extensive fibrosis, & conversion of liver architecture into structurally abnormal nodules

                                                    IMAGING

                                                    • General Features

                                                      • CT Findings

                                                        • MR Findings

                                                          • Ultrasonographic Findings

                                                            • Imaging Recommendations

                                                              DIFFERENTIAL DIAGNOSIS

                                                                PATHOLOGY

                                                                • General Features

                                                                  • Staging, Grading, & Classification

                                                                    • Gross Pathologic & Surgical Features

                                                                      • Microscopic Features

                                                                        CLINICAL ISSUES

                                                                        • Presentation

                                                                          • Demographics

                                                                            • Natural History & Prognosis

                                                                              • Treatment

                                                                                DIAGNOSTIC CHECKLIST

                                                                                • Consider

                                                                                  • Image Interpretation Pearls

                                                                                    • Reporting Tips

                                                                                      Selected References

                                                                                      1. Ajmera VH et al: Clinical utility of an increase in magnetic resonance elastography in predicting fibrosis progression in nonalcoholic fatty liver disease. Hepatology. 71(3):849-60, 2020
                                                                                      2. Cannella R et al: Liver Imaging Reporting and Data System (LI-RADS) v2018: diagnostic value of ancillary features favoring malignancy in hypervascular observations ≥10 mm at intermediate (LR-3) and high probability (LR-4) for hepatocellular carcinoma. Eur Radiol. 30(7):3770-81, 2020
                                                                                      3. Khalifa A et al: Lower gastrointestinal bleeding in patients with cirrhosis-etiology and outcomes. Am J Med Sci. 359(4):206-11, 2020
                                                                                      4. Kim SS et al: Value of gadoxetic acid-enhanced MRI and diffusion-weighted imaging in the differentiation of hypervascular hyperplastic nodule from small (<3 cm) hypervascular hepatocellular carcinoma in patients with alcoholic liver cirrhosis: A retrospective case-control study. J Magn Reson Imaging. 51(1):70-80, 2020
                                                                                      5. Lashen SA et al: Liver stiffness as a predictor of hepatocellular carcinoma behavior in patients with hepatitis C related liver cirrhosis. Hepatobiliary Pancreat Dis Int. 19(1):22-8, 2020
                                                                                      6. Møller S et al: Pathophysiological-based treatments of complications of cirrhosis. Scand J Gastroenterol. 1-12, 2020
                                                                                      7. Semaan S et al: Hepatocellular carcinoma detection in liver cirrhosis: diagnostic performance of contrast-enhanced CT vs. MRI with extracellular contrast vs. gadoxetic acid. Eur Radiol. 30(2):1020-30, 2020
                                                                                      8. Singh R et al: Accuracy of liver and spleen stiffness on magnetic resonance elastography for detecting portal hypertension: a systematic review and meta-analysis. Eur J Gastroenterol Hepatol. ePub, 2020
                                                                                      9. Zhang YN et al: Liver fibrosis imaging: a clinical review of ultrasound and magnetic resonance elastography. J Magn Reson Imaging. 51(1):25-42, 2020
                                                                                      10. Guglielmo FF et al: Liver MR elastography technique and image interpretation: pearls and pitfalls. Radiographics. 39(7):1983-2002, 2019
                                                                                      11. Kozaka K et al: Doughnut-like hyperintense nodules on hepatobiliary phase without arterial-phase hyperenhancement in cirrhotic liver: imaging and clinicopathological features. Eur Radiol. 29(12):6489-98, 2019
                                                                                      12. Rodgers SK et al: Role of US LI-RADS in the LI-RADS algorithm. Radiographics. 39(3):690-708, 2019
                                                                                      13. Schwope RB et al: The many faces of cirrhosis. Abdom Radiol (NY). 45(10): 3065-80, 2019
                                                                                      14. Barnett R: Liver cirrhosis. Lancet. 392(10144):275, 2018
                                                                                      15. Elsayes KM et al: Spectrum of pitfalls, pseudolesions, and potential misdiagnoses in cirrhosis. AJR Am J Roentgenol. 211(1):87-96, 2018
                                                                                      16. Inchingolo R et al: MR with Gd-EOB-DTPA in assessment of liver nodules in cirrhotic patients. World J Hepatol. 10(7):462-73, 2018
                                                                                      17. Poullos PD et al: Structured reporting of multiphasic CT for hepatocellular carcinoma: effect on staging and suitability for transplant. AJR Am J Roentgenol. 210(4):766-74, 2018
                                                                                      18. Cho HJ et al: Development of risk prediction model for hepatocellular carcinoma progression of indeterminate nodules in hepatitis B virus-related cirrhotic liver. Am J Gastroenterol. 112(3):460-70, 2017
                                                                                      19. Petitclerc L et al: Liver fibrosis: review of current imaging and MRI quantification techniques. J Magn Reson Imaging. 45(5):1276-95, 2017
                                                                                      20. Li RK et al: Detection of endogenous iron reduction during hepatocarcinogenesis at susceptibility-weighted MR imaging: value for characterization of hepatocellular carcinoma and dysplastic nodule in cirrhotic liver. PLoS One. 10(11):e0142882, 2015
                                                                                      21. Beland MD et al: A pilot study estimating liver fibrosis with ultrasound shear-wave elastography: does the cause of liver disease or location of measurement affect performance? AJR Am J Roentgenol. 203(3):W267-73, 2014
                                                                                      22. Jha RC et al: LI-RADS categorization of benign and likely benign findings in patients at risk of hepatocellular carcinoma: a pictorial atlas. AJR Am J Roentgenol. 203(1):W48-69, 2014
                                                                                      23. Khalili K et al: Indeterminate 1-2-cm nodules found on hepatocellular carcinoma surveillance: biopsy for all, some, or none? Hepatology. 54(6):2048-54, 2011
                                                                                      24. Vivarelli M et al: Liver transplantation for hepatocellular carcinoma on cirrhosis: strategies to avoid tumor recurrence. World J Gastroenterol. 17(43):4741-6, 2011
                                                                                      25. European Association for the Study of the Liver: EASL clinical practice guidelines on the management of ascites, spontaneous bacterial peritonitis, and hepatorenal syndrome in cirrhosis. J Hepatol. 53(3):397-417, 2010
                                                                                      26. Boll DT et al: Diffuse liver disease: strategies for hepatic CT and MR imaging. Radiographics. 29(6):1591-614, 2009