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Clear Cell Carcinoma
Akram M. Shaaban, MBBCh; Oguz Akin, MD
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KEY FACTS

  • Terminology

    • Imaging

      • Top Differential Diagnoses

        • Pathology

          • Clinical Issues

            TERMINOLOGY

            • Abbreviations

              • Clear cell carcinoma (CCC)
            • Definitions

              • Classified as malignant epithelial tumor
              • 1st termed mesonephroma to describe ovarian neoplasm composed of clear and hobnail cells with pattern resembling immature glomeruli

            IMAGING

            • General Features

              • CT Findings

                • MR Findings

                  • Ultrasonographic Findings

                    • Imaging Recommendations

                      DIFFERENTIAL DIAGNOSIS

                        PATHOLOGY

                        • General Features

                          • Staging, Grading, & Classification

                            • Gross Pathologic & Surgical Features

                              • Microscopic Features

                                CLINICAL ISSUES

                                • Presentation

                                  • Demographics

                                    • Natural History & Prognosis

                                      • Treatment

                                        DIAGNOSTIC CHECKLIST

                                        • Consider

                                          • Image Interpretation Pearls

                                            Selected References

                                            1. Pozzati F et al: Imaging in gynecological disease (14): clinical and ultrasound characteristics of ovarian clear cell carcinoma. Ultrasound Obstet Gynecol. 52(6):792-800, 2018
                                            2. Ma FH et al: Magnetic resonance imaging for distinguishing ovarian clear cell carcinoma from high-grade serous carcinoma. J Ovarian Res. 9(1):40, 2016
                                            3. Li X et al: Clear cell carcinoma of the ovary: multi-slice computed tomography findings. World J Surg Oncol. 13:133, 2015
                                            4. del Carmen MG et al: Clear cell carcinoma of the ovary: a review of the literature. Gynecol Oncol. 126(3):481-90, 2012
                                            5. McDermott S et al: MR imaging of malignancies arising in endometriomas and extraovarian endometriosis. Radiographics. 32(3):845-63, 2012
                                            6. Siegelman ES et al: MR imaging of endometriosis: ten imaging pearls. Radiographics. 32(6):1675-91, 2012
                                            7. Lalwani N et al: Histologic, molecular, and cytogenetic features of ovarian cancers: implications for diagnosis and treatment. Radiographics. 31(3):625-46, 2011
                                            8. Manabe T et al: Magnetic resonance imaging of endometrial cancer and clear cell cancer. J Comput Assist Tomogr. 31(2):229-35, 2007
                                            9. Sugiyama K et al: Magnetic resonance findings of clear-cell adenocarcinofibroma of the ovary. Acta Radiol. 48(6):704-6, 2007
                                            10. Imaoka I et al: Developing an MR imaging strategy for diagnosis of ovarian masses. Radiographics. 26(5):1431-48, 2006
                                            11. Takano M et al: Clear cell carcinoma of the ovary: a retrospective multicentre experience of 254 patients with complete surgical staging. Br J Cancer. 2006
                                            12. Togashi K. Related Articles et al: Ovarian cancer: the clinical role of US, CT, and MRI. Eur Radiol. 13 Suppl 4:L87-104, 2003
                                            13. Matsuoka Y et al: MR imaging of clear cell carcinoma of the ovary. Eur Radiol. 11(6):946-51, 2001
                                            Related Anatomy
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                                            Related Differential Diagnoses
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                                            References
                                            Tables

                                            Tables

                                            KEY FACTS

                                            • Terminology

                                              • Imaging

                                                • Top Differential Diagnoses

                                                  • Pathology

                                                    • Clinical Issues

                                                      TERMINOLOGY

                                                      • Abbreviations

                                                        • Clear cell carcinoma (CCC)
                                                      • Definitions

                                                        • Classified as malignant epithelial tumor
                                                        • 1st termed mesonephroma to describe ovarian neoplasm composed of clear and hobnail cells with pattern resembling immature glomeruli

                                                      IMAGING

                                                      • General Features

                                                        • CT Findings

                                                          • MR Findings

                                                            • Ultrasonographic Findings

                                                              • Imaging Recommendations

                                                                DIFFERENTIAL DIAGNOSIS

                                                                  PATHOLOGY

                                                                  • General Features

                                                                    • Staging, Grading, & Classification

                                                                      • Gross Pathologic & Surgical Features

                                                                        • Microscopic Features

                                                                          CLINICAL ISSUES

                                                                          • Presentation

                                                                            • Demographics

                                                                              • Natural History & Prognosis

                                                                                • Treatment

                                                                                  DIAGNOSTIC CHECKLIST

                                                                                  • Consider

                                                                                    • Image Interpretation Pearls

                                                                                      Selected References

                                                                                      1. Pozzati F et al: Imaging in gynecological disease (14): clinical and ultrasound characteristics of ovarian clear cell carcinoma. Ultrasound Obstet Gynecol. 52(6):792-800, 2018
                                                                                      2. Ma FH et al: Magnetic resonance imaging for distinguishing ovarian clear cell carcinoma from high-grade serous carcinoma. J Ovarian Res. 9(1):40, 2016
                                                                                      3. Li X et al: Clear cell carcinoma of the ovary: multi-slice computed tomography findings. World J Surg Oncol. 13:133, 2015
                                                                                      4. del Carmen MG et al: Clear cell carcinoma of the ovary: a review of the literature. Gynecol Oncol. 126(3):481-90, 2012
                                                                                      5. McDermott S et al: MR imaging of malignancies arising in endometriomas and extraovarian endometriosis. Radiographics. 32(3):845-63, 2012
                                                                                      6. Siegelman ES et al: MR imaging of endometriosis: ten imaging pearls. Radiographics. 32(6):1675-91, 2012
                                                                                      7. Lalwani N et al: Histologic, molecular, and cytogenetic features of ovarian cancers: implications for diagnosis and treatment. Radiographics. 31(3):625-46, 2011
                                                                                      8. Manabe T et al: Magnetic resonance imaging of endometrial cancer and clear cell cancer. J Comput Assist Tomogr. 31(2):229-35, 2007
                                                                                      9. Sugiyama K et al: Magnetic resonance findings of clear-cell adenocarcinofibroma of the ovary. Acta Radiol. 48(6):704-6, 2007
                                                                                      10. Imaoka I et al: Developing an MR imaging strategy for diagnosis of ovarian masses. Radiographics. 26(5):1431-48, 2006
                                                                                      11. Takano M et al: Clear cell carcinoma of the ovary: a retrospective multicentre experience of 254 patients with complete surgical staging. Br J Cancer. 2006
                                                                                      12. Togashi K. Related Articles et al: Ovarian cancer: the clinical role of US, CT, and MRI. Eur Radiol. 13 Suppl 4:L87-104, 2003
                                                                                      13. Matsuoka Y et al: MR imaging of clear cell carcinoma of the ovary. Eur Radiol. 11(6):946-51, 2001