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Clear Cell Chondrosarcoma
Behrang Amini, MD, PhD; B. J. Manaster, MD, PhD, FACR
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KEY FACTS

  • Terminology

    • Imaging

      • Top Differential Diagnoses

        • Clinical Issues

          • Diagnostic Checklist

            TERMINOLOGY

            • Definitions

              • Rare, low-grade variant of chondrosarcoma, usually originating in epiphysis

            IMAGING

            • General Features

              • Radiographic Findings

                • MR Findings

                  DIFFERENTIAL DIAGNOSIS

                    PATHOLOGY

                    • Microscopic Features

                      CLINICAL ISSUES

                      • Presentation

                        • Demographics

                          • Natural History & Prognosis

                            DIAGNOSTIC CHECKLIST

                            • Consider

                              • Image Interpretation Pearls

                                Selected References

                                1. Baumhoer D et al: Clear cell chondrosarcoma. In Fletcher CDM et al: WHO Classification of Tumours: Tumours of Soft Tissue and Bone. IARC Press. 383-4, 2020
                                2. Klein A et al: Clear cell chondrosarcoma is an underestimated tumor: report of 7 cases and meta-analysis of the literature. J Bone Oncol. 19:100267, 2019
                                3. Chow LT et al: Epiphyseal osteosarcoma revisited: four illustrative cases with unusual histopathology and literature review. APMIS. 123(1):9-17, 2015
                                4. Liska F et al: Delayed diagnosis of clear cell chondrosarcoma after total hip replacement. A case report of a rare entity encountered in common surgery. Hip Int. 25(1):98-100, 2015
                                5. Jiang XS et al: Clear cell chondrosarcoma: cytologic findings in six cases. Diagn Cytopathol. 42(9):784-91, 2014
                                6. Manfrini M et al: Multiple or metastatic clear cell chondrosarcoma: a case report. Clin Sarcoma Res. 4:12, 2014
                                7. Tay T et al: Clear cell chondrosarcoma with secondary aneurysmal bone cyst changes. Singapore Med J. 55(3):e49-51, 2014
                                8. Douis H et al: The imaging of cartilaginous bone tumours. II. Chondrosarcoma. Skeletal Radiol. 42(5):611-26, 2013
                                9. Donati D et al: Clear cell chondrosarcoma of bone: long time follow-up of 18 cases. Arch Orthop Trauma Surg. 128(2):137-42, 2008
                                10. Corradi D et al: Aggressive clear cell chondrosarcomas: do distinctive characteristics exist?: a report of 4 cases. Arch Pathol Lab Med. 130(11):1673-9, 2006
                                11. Tessitore E et al: Primary clear-cell chondrosarcoma of the cervical spine. Case illustration. J Neurosurg Spine. 4(5):424, 2006
                                12. Ayoub KS et al: Clear cell chondrosarcoma of bone. Sarcoma. 3(2):115-9, 1999
                                Related Anatomy
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                                Related Differential Diagnoses
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                                References
                                Tables

                                Tables

                                KEY FACTS

                                • Terminology

                                  • Imaging

                                    • Top Differential Diagnoses

                                      • Clinical Issues

                                        • Diagnostic Checklist

                                          TERMINOLOGY

                                          • Definitions

                                            • Rare, low-grade variant of chondrosarcoma, usually originating in epiphysis

                                          IMAGING

                                          • General Features

                                            • Radiographic Findings

                                              • MR Findings

                                                DIFFERENTIAL DIAGNOSIS

                                                  PATHOLOGY

                                                  • Microscopic Features

                                                    CLINICAL ISSUES

                                                    • Presentation

                                                      • Demographics

                                                        • Natural History & Prognosis

                                                          DIAGNOSTIC CHECKLIST

                                                          • Consider

                                                            • Image Interpretation Pearls

                                                              Selected References

                                                              1. Baumhoer D et al: Clear cell chondrosarcoma. In Fletcher CDM et al: WHO Classification of Tumours: Tumours of Soft Tissue and Bone. IARC Press. 383-4, 2020
                                                              2. Klein A et al: Clear cell chondrosarcoma is an underestimated tumor: report of 7 cases and meta-analysis of the literature. J Bone Oncol. 19:100267, 2019
                                                              3. Chow LT et al: Epiphyseal osteosarcoma revisited: four illustrative cases with unusual histopathology and literature review. APMIS. 123(1):9-17, 2015
                                                              4. Liska F et al: Delayed diagnosis of clear cell chondrosarcoma after total hip replacement. A case report of a rare entity encountered in common surgery. Hip Int. 25(1):98-100, 2015
                                                              5. Jiang XS et al: Clear cell chondrosarcoma: cytologic findings in six cases. Diagn Cytopathol. 42(9):784-91, 2014
                                                              6. Manfrini M et al: Multiple or metastatic clear cell chondrosarcoma: a case report. Clin Sarcoma Res. 4:12, 2014
                                                              7. Tay T et al: Clear cell chondrosarcoma with secondary aneurysmal bone cyst changes. Singapore Med J. 55(3):e49-51, 2014
                                                              8. Douis H et al: The imaging of cartilaginous bone tumours. II. Chondrosarcoma. Skeletal Radiol. 42(5):611-26, 2013
                                                              9. Donati D et al: Clear cell chondrosarcoma of bone: long time follow-up of 18 cases. Arch Orthop Trauma Surg. 128(2):137-42, 2008
                                                              10. Corradi D et al: Aggressive clear cell chondrosarcomas: do distinctive characteristics exist?: a report of 4 cases. Arch Pathol Lab Med. 130(11):1673-9, 2006
                                                              11. Tessitore E et al: Primary clear-cell chondrosarcoma of the cervical spine. Case illustration. J Neurosurg Spine. 4(5):424, 2006
                                                              12. Ayoub KS et al: Clear cell chondrosarcoma of bone. Sarcoma. 3(2):115-9, 1999