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Clear Cell Sarcoma
Stephanie A. Bernard, MD
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KEY FACTS

  • Terminology

    • Imaging

      • Top Differential Diagnoses

        • Pathology

          • Clinical Issues

            TERMINOLOGY

            • Abbreviations

              • Clear cell sarcoma (CCS)
            • Synonyms

              • Formerly: malignant melanoma of soft parts
            • Definitions

              • WHO categorizes as malignant tumor of uncertain differentiation; harbors melanocytic differentiation

            IMAGING

            • General Features

              • Radiographic Findings

                • CT Findings

                  • MR Findings

                    • Ultrasonographic Findings

                      • Imaging Recommendations

                        DIFFERENTIAL DIAGNOSIS

                          PATHOLOGY

                          • General Features

                            • Gross Pathologic & Surgical Features

                              • Microscopic Features

                                • Stains/Immunohistochemistry

                                  CLINICAL ISSUES

                                  • Presentation

                                    • Demographics

                                      • Natural History & Prognosis

                                        • Treatment

                                          Selected References

                                          1. Fletcher CDM et al: World Health Organization Classification of Tumours: Soft Tissue and Bone Tumours. 5th ed. IARC Press, 2020
                                          2. Obiorah IE et al: Clear cell sarcoma in unusual sites mimicking metastatic melanoma. World J Clin Oncol. 10(5):213-21, 2019
                                          3. Gonzaga MI et al: The epidemiology and survivorship of clear cell sarcoma: a National Cancer Database (NCDB) review. J Cancer Res Clin Oncol. 144(9):1711-6, 2018
                                          4. Ibrahim RM et al: Clear cell sarcoma-a review. J Orthop. 15(4):963-6, 2018
                                          5. Sharma K et al: Significance of MRI in the diagnosis and differentiation of clear cell sarcoma of tendon and aponeurosis (CCSTA): a case report. Medicine (Baltimore). 97(31):e11012, 2018
                                          6. Bianchi G et al: Clear cell sarcoma of soft tissue: a retrospective review and analysis of 31 cases treated at Istituto Ortopedico Rizzoli. Eur J Surg Oncol. 40(5):505-10, 2014
                                          7. Clark MA et al: Clear cell sarcoma (melanoma of soft parts): the Royal Marsden Hospital experience. Eur J Surg Oncol. 34(7):800-4, 2008
                                          8. Kransdorf MJ et al: Imaging of Soft Tissue Tumors. 2nd ed. Lippincott Williams & Wilkins, 2006
                                          9. De Beuckeleer LH et al: MR imaging of clear cell sarcoma (malignant melanoma of the soft parts): a multicenter correlative MRI-pathology study of 21 cases and literature review. Skeletal Radiol. 29(4):187-95, 2000
                                          Related Anatomy
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                                          Related Differential Diagnoses
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                                          References
                                          Tables

                                          Tables

                                          KEY FACTS

                                          • Terminology

                                            • Imaging

                                              • Top Differential Diagnoses

                                                • Pathology

                                                  • Clinical Issues

                                                    TERMINOLOGY

                                                    • Abbreviations

                                                      • Clear cell sarcoma (CCS)
                                                    • Synonyms

                                                      • Formerly: malignant melanoma of soft parts
                                                    • Definitions

                                                      • WHO categorizes as malignant tumor of uncertain differentiation; harbors melanocytic differentiation

                                                    IMAGING

                                                    • General Features

                                                      • Radiographic Findings

                                                        • CT Findings

                                                          • MR Findings

                                                            • Ultrasonographic Findings

                                                              • Imaging Recommendations

                                                                DIFFERENTIAL DIAGNOSIS

                                                                  PATHOLOGY

                                                                  • General Features

                                                                    • Gross Pathologic & Surgical Features

                                                                      • Microscopic Features

                                                                        • Stains/Immunohistochemistry

                                                                          CLINICAL ISSUES

                                                                          • Presentation

                                                                            • Demographics

                                                                              • Natural History & Prognosis

                                                                                • Treatment

                                                                                  Selected References

                                                                                  1. Fletcher CDM et al: World Health Organization Classification of Tumours: Soft Tissue and Bone Tumours. 5th ed. IARC Press, 2020
                                                                                  2. Obiorah IE et al: Clear cell sarcoma in unusual sites mimicking metastatic melanoma. World J Clin Oncol. 10(5):213-21, 2019
                                                                                  3. Gonzaga MI et al: The epidemiology and survivorship of clear cell sarcoma: a National Cancer Database (NCDB) review. J Cancer Res Clin Oncol. 144(9):1711-6, 2018
                                                                                  4. Ibrahim RM et al: Clear cell sarcoma-a review. J Orthop. 15(4):963-6, 2018
                                                                                  5. Sharma K et al: Significance of MRI in the diagnosis and differentiation of clear cell sarcoma of tendon and aponeurosis (CCSTA): a case report. Medicine (Baltimore). 97(31):e11012, 2018
                                                                                  6. Bianchi G et al: Clear cell sarcoma of soft tissue: a retrospective review and analysis of 31 cases treated at Istituto Ortopedico Rizzoli. Eur J Surg Oncol. 40(5):505-10, 2014
                                                                                  7. Clark MA et al: Clear cell sarcoma (melanoma of soft parts): the Royal Marsden Hospital experience. Eur J Surg Oncol. 34(7):800-4, 2008
                                                                                  8. Kransdorf MJ et al: Imaging of Soft Tissue Tumors. 2nd ed. Lippincott Williams & Wilkins, 2006
                                                                                  9. De Beuckeleer LH et al: MR imaging of clear cell sarcoma (malignant melanoma of the soft parts): a multicenter correlative MRI-pathology study of 21 cases and literature review. Skeletal Radiol. 29(4):187-95, 2000