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CLIPPERS
Anne G. Osborn, MD, FACR
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KEY FACTS

  • Terminology

    • Imaging

      • Top Differential Diagnoses

        • Clinical Issues

          TERMINOLOGY

          • Abbreviations

            • Chronic lymphocytic inflammation with pontine perivascular enhancement responsive to steroids (CLIPPERS)
          • Definitions

            • Recently described inflammatory CNS disorder
            • Predominantly involving brainstem, adjacent rhombencephalic structures
            • Clinical, imaging response to glucocorticosteroids

          IMAGING

          • General Features

            • CT Findings

              • MR Findings

                • Angiographic Findings

                  • Imaging Recommendations

                    DIFFERENTIAL DIAGNOSIS

                      PATHOLOGY

                      • General Features

                        • Microscopic Features

                          CLINICAL ISSUES

                          • Presentation

                            • Demographics

                              • Natural History & Prognosis

                                • Treatment

                                  Selected References

                                  1. Gul M et al: Atypical Presentation of CLIPPERS Syndrome: A New Entity in the Differential Diagnosis of Central Nervous System Rheumatologic Diseases. J Clin Rheumatol. 21(3):144-8, 2015
                                  2. Dudesek A et al: CLIPPERS: chronic lymphocytic inflammation with pontine perivascular enhancement responsive to steroids. Review of an increasingly recognized entity within the spectrum of inflammatory central nervous system disorders. Clin Exp Immunol. 175(3):385-96, 2014
                                  3. Pittock SJ et al: Chronic lymphocytic inflammation with pontine perivascular enhancement responsive to steroids (CLIPPERS). Brain. 133(9):2626-34, 2010
                                  Related Anatomy
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                                  Related Differential Diagnoses
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                                  References
                                  Tables

                                  Tables

                                  KEY FACTS

                                  • Terminology

                                    • Imaging

                                      • Top Differential Diagnoses

                                        • Clinical Issues

                                          TERMINOLOGY

                                          • Abbreviations

                                            • Chronic lymphocytic inflammation with pontine perivascular enhancement responsive to steroids (CLIPPERS)
                                          • Definitions

                                            • Recently described inflammatory CNS disorder
                                            • Predominantly involving brainstem, adjacent rhombencephalic structures
                                            • Clinical, imaging response to glucocorticosteroids

                                          IMAGING

                                          • General Features

                                            • CT Findings

                                              • MR Findings

                                                • Angiographic Findings

                                                  • Imaging Recommendations

                                                    DIFFERENTIAL DIAGNOSIS

                                                      PATHOLOGY

                                                      • General Features

                                                        • Microscopic Features

                                                          CLINICAL ISSUES

                                                          • Presentation

                                                            • Demographics

                                                              • Natural History & Prognosis

                                                                • Treatment

                                                                  Selected References

                                                                  1. Gul M et al: Atypical Presentation of CLIPPERS Syndrome: A New Entity in the Differential Diagnosis of Central Nervous System Rheumatologic Diseases. J Clin Rheumatol. 21(3):144-8, 2015
                                                                  2. Dudesek A et al: CLIPPERS: chronic lymphocytic inflammation with pontine perivascular enhancement responsive to steroids. Review of an increasingly recognized entity within the spectrum of inflammatory central nervous system disorders. Clin Exp Immunol. 175(3):385-96, 2014
                                                                  3. Pittock SJ et al: Chronic lymphocytic inflammation with pontine perivascular enhancement responsive to steroids (CLIPPERS). Brain. 133(9):2626-34, 2010