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Breast
Lesion Imaging Characteristics
Ultrasound Lesion Characteristics
Clustered Microcysts (US)
Clustered Microcysts (US)
Wendie A. Berg, MD, PhD, FACR, FSBI
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KEY FACTS

  • Imaging

    • Top Differential Diagnoses

      • Clinical Issues

        TERMINOLOGY

        • Definitions

          • Mass consisting of group of 1- to 7-mm cysts with thin (< 0.5 mm), intervening septa
          • No solid component

        IMAGING

        • General Features

          • Mammographic Findings

            • Ultrasonographic Findings

              • MR Findings

                • Imaging Recommendations

                  • Image-Guided Biopsy

                    DIFFERENTIAL DIAGNOSIS

                      PATHOLOGY

                      • General Features

                        • Microscopic Features

                          CLINICAL ISSUES

                          • Presentation

                            • Demographics

                              • Natural History & Prognosis

                                • Treatment

                                  DIAGNOSTIC CHECKLIST

                                  • Consider

                                    • Image Interpretation Pearls

                                      Selected References

                                      1. Greenwood HI et al: Clustered microcysts on breast ultrasound: What is the appropriate management? AJR Am J Roentgenol 209:W1-W5, 2017
                                      2. Mendelson EB et al. ACR BI-RADS Ultrasound. ACR BI-RADS Atlas, Breast Imaging Reporting and Data System. Reston, VA: American College of Radiology, 2013
                                      3. Berg WA et al: Cystic breast masses and the ACRIN 6666 experience. Radiol Clin North Am. 48(5):931-87, 2010
                                      4. Daly CP et al: Complicated breast cysts on sonography: is aspiration necessary to exclude malignancy? Acad Radiol. 15(5):610-7, 2008
                                      5. Chang YW et al: Sonographic differentiation of benign and malignant cystic lesions of the breast. J Ultrasound Med. 26(1):47-53, 2007
                                      6. Berg WA: Sonographically depicted breast clustered microcysts: is follow-up appropriate? AJR Am J Roentgenol. 185(4):952-9, 2005
                                      7. Berg WA: Breast ultrasonography: cystic lesions and probably benign findings. In Berg WA et al: Women's Imaging: Strategies for Clinical Practice--Categorical Course Syllabus. Leesburg: American Roentgen Ray Society. 95-102, 2004
                                      8. Berg WA et al: Cystic lesions of the breast: sonographic-pathologic correlation. Radiology. 227(1):183-91, 2003
                                      9. Kushwaha AC et al: Mammographic-pathologic correlation of apocrine metaplasia diagnosed using vacuum-assisted stereotactic core-needle biopsy: our 4-year experience. AJR Am J Roentgenol. 180(3):795-8, 2003
                                      10. Szopinski KT et al: Tissue harmonic imaging: utility in breast sonography. J Ultrasound Med. 22(5):479-87; quiz 488- 9, 2003
                                      11. Seo BK et al: Sonographic evaluation of breast nodules: comparison of conventional, real-time compound, and pulse-inversion harmonic images. Korean J Radiol. 3(1):38-44, 2002
                                      12. Mendelson EB et al: Toward a standardized breast ultrasound lexicon, BI-RADS: ultrasound. Semin Roentgenol. 36(3):217-25, 2001
                                      13. Moy L et al: The pendent view: An additional projection to confirm the diagnosis of milk-of-calcium. AJR. 177:173-5, 2001
                                      14. Margolin FR et al: Microcystic calcifications at stereotactic breast biopsy. Breast J. 5(3):182-185, 1999
                                      15. Venta LA et al: Management of complex breast cysts. AJR Am J Roentgenol. 173(5):1331-6, 1999
                                      16. Warner JK et al: Apocrine metaplasia: mammographic and sonographic appearances. AJR Am J Roentgenol. 170(5):1375-9, 1998
                                      17. Linden SS et al: Sedimented calcium in benign breast cysts: the full spectrum of mammographic presentations. AJR Am J Roentgenol. 152(5):967-71, 1989
                                      18. Wellings SR et al: An atlas of subgross pathology of the human breast with special reference to possible precancerous lesions. J Natl Cancer Inst. 55(2):231-73, 1975
                                      Related Anatomy
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                                      Related Differential Diagnoses
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                                      References
                                      Tables

                                      Tables

                                      KEY FACTS

                                      • Imaging

                                        • Top Differential Diagnoses

                                          • Clinical Issues

                                            TERMINOLOGY

                                            • Definitions

                                              • Mass consisting of group of 1- to 7-mm cysts with thin (< 0.5 mm), intervening septa
                                              • No solid component

                                            IMAGING

                                            • General Features

                                              • Mammographic Findings

                                                • Ultrasonographic Findings

                                                  • MR Findings

                                                    • Imaging Recommendations

                                                      • Image-Guided Biopsy

                                                        DIFFERENTIAL DIAGNOSIS

                                                          PATHOLOGY

                                                          • General Features

                                                            • Microscopic Features

                                                              CLINICAL ISSUES

                                                              • Presentation

                                                                • Demographics

                                                                  • Natural History & Prognosis

                                                                    • Treatment

                                                                      DIAGNOSTIC CHECKLIST

                                                                      • Consider

                                                                        • Image Interpretation Pearls

                                                                          Selected References

                                                                          1. Greenwood HI et al: Clustered microcysts on breast ultrasound: What is the appropriate management? AJR Am J Roentgenol 209:W1-W5, 2017
                                                                          2. Mendelson EB et al. ACR BI-RADS Ultrasound. ACR BI-RADS Atlas, Breast Imaging Reporting and Data System. Reston, VA: American College of Radiology, 2013
                                                                          3. Berg WA et al: Cystic breast masses and the ACRIN 6666 experience. Radiol Clin North Am. 48(5):931-87, 2010
                                                                          4. Daly CP et al: Complicated breast cysts on sonography: is aspiration necessary to exclude malignancy? Acad Radiol. 15(5):610-7, 2008
                                                                          5. Chang YW et al: Sonographic differentiation of benign and malignant cystic lesions of the breast. J Ultrasound Med. 26(1):47-53, 2007
                                                                          6. Berg WA: Sonographically depicted breast clustered microcysts: is follow-up appropriate? AJR Am J Roentgenol. 185(4):952-9, 2005
                                                                          7. Berg WA: Breast ultrasonography: cystic lesions and probably benign findings. In Berg WA et al: Women's Imaging: Strategies for Clinical Practice--Categorical Course Syllabus. Leesburg: American Roentgen Ray Society. 95-102, 2004
                                                                          8. Berg WA et al: Cystic lesions of the breast: sonographic-pathologic correlation. Radiology. 227(1):183-91, 2003
                                                                          9. Kushwaha AC et al: Mammographic-pathologic correlation of apocrine metaplasia diagnosed using vacuum-assisted stereotactic core-needle biopsy: our 4-year experience. AJR Am J Roentgenol. 180(3):795-8, 2003
                                                                          10. Szopinski KT et al: Tissue harmonic imaging: utility in breast sonography. J Ultrasound Med. 22(5):479-87; quiz 488- 9, 2003
                                                                          11. Seo BK et al: Sonographic evaluation of breast nodules: comparison of conventional, real-time compound, and pulse-inversion harmonic images. Korean J Radiol. 3(1):38-44, 2002
                                                                          12. Mendelson EB et al: Toward a standardized breast ultrasound lexicon, BI-RADS: ultrasound. Semin Roentgenol. 36(3):217-25, 2001
                                                                          13. Moy L et al: The pendent view: An additional projection to confirm the diagnosis of milk-of-calcium. AJR. 177:173-5, 2001
                                                                          14. Margolin FR et al: Microcystic calcifications at stereotactic breast biopsy. Breast J. 5(3):182-185, 1999
                                                                          15. Venta LA et al: Management of complex breast cysts. AJR Am J Roentgenol. 173(5):1331-6, 1999
                                                                          16. Warner JK et al: Apocrine metaplasia: mammographic and sonographic appearances. AJR Am J Roentgenol. 170(5):1375-9, 1998
                                                                          17. Linden SS et al: Sedimented calcium in benign breast cysts: the full spectrum of mammographic presentations. AJR Am J Roentgenol. 152(5):967-71, 1989
                                                                          18. Wellings SR et al: An atlas of subgross pathology of the human breast with special reference to possible precancerous lesions. J Natl Cancer Inst. 55(2):231-73, 1975
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