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KEY FACTS
Terminology
Imaging
Top Differential Diagnoses
Pathology
Clinical Issues
Diagnostic Checklist
TERMINOLOGY
Abbreviations
- Combined pulmonary fibrosis and emphysema (CPFE)
Definitions
- Idiopathic pulmonary fibrosis (IPF)/usual interstitial pneumonia (UIP) pattern on background of emphysema
- Other chronic fibrosing interstitial lung disease (ILD) on background of emphysema
- Distinct but heterogeneous clinical entity, most often affects current or former heavy smokers
IMAGING
General Features
Radiographic Findings
CT Findings
Imaging Recommendations
DIFFERENTIAL DIAGNOSIS
PATHOLOGY
General Features
Microscopic Features
CLINICAL ISSUES
Presentation
Demographics
Natural History & Prognosis
Treatment
Diagnosis
DIAGNOSTIC CHECKLIST
Image Interpretation Pearls
Reporting Tips
Selected References
- Hage R et al: Combined pulmonary fibrosis and emphysema (CPFE) clinical features and management. Int J Chron Obstruct Pulmon Dis. 16:167-77, 2021
- Bolaki M et al: Combined pulmonary fibrosis and emphysema. Semin Respir Crit Care Med. 41(2):177-83, 2020
- Amariei DE et al: Combined pulmonary fibrosis and emphysema: pulmonary function testing and a pathophysiology perspective. Medicina (Kaunas). 55(9), 2019
- Sousa C et al: Diffuse smoking-related lung diseases: insights from a radiologic-pathologic correlation. Insights Imaging. 10(1):73, 2019
- Hashimoto N et al: Impact of thin-section computed tomography-determined combined pulmonary fibrosis and emphysema on outcomes among patients with resected lung cancer. Ann Thorac Surg. 102(2):440-7, 2016
- Lin H et al: Combined pulmonary fibrosis and emphysema (CPFE): an entity different from emphysema or pulmonary fibrosis alone. J Thorac Dis. 7(4):767-79, 2015
- Choi SH et al: The value of CT for disease detection and prognosis determination in combined pulmonary fibrosis and emphysema (CPFE). PLoS One. 9(9):e107476, 2014
- Jankowich MD et al: Combined pulmonary fibrosis and emphysema syndrome: a review. Chest. 141(1):222-31, 2012
- Sakai F et al: Imaging diagnosis of interstitial pneumonia with emphysema (combined pulmonary fibrosis and emphysema). Pulm Med. 2012:816541, 2012
- Wright JL et al: Fibrosis with emphysema. Histopathology. 58(4):517-24, 2011
- Chung JH et al: Smoking-related interstitial lung diseases. Semin Roentgenol. 45(1):29-35, 2010
- Attili AK et al: Smoking-related interstitial lung disease: radiologic-clinical-pathologic correlation. Radiographics. 28(5):1383-96; discussion 1396-8, 2008
- Rao RN et al: Smoking-related interstitial lung disease. Ann Diagn Pathol. 12(6):445-57, 2008
- Wells AU et al: Challenges in pulmonary fibrosis. 4: smoking-induced diffuse interstitial lung diseases. Thorax. 62(10):904-10, 2007
- Hidalgo A et al: Smoking-related interstitial lung diseases: radiologic-pathologic correlation. Eur Radiol. 16(11):2463-70, 2006
- Remy-Jardin M et al: Lung parenchymal changes secondary to cigarette smoking: pathologic-CT correlations. Radiology. 186(3):643-51, 1993
Related Anatomy
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Related Differential Diagnoses
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References
Tables
Tables
KEY FACTS
Terminology
Imaging
Top Differential Diagnoses
Pathology
Clinical Issues
Diagnostic Checklist
TERMINOLOGY
Abbreviations
- Combined pulmonary fibrosis and emphysema (CPFE)
Definitions
- Idiopathic pulmonary fibrosis (IPF)/usual interstitial pneumonia (UIP) pattern on background of emphysema
- Other chronic fibrosing interstitial lung disease (ILD) on background of emphysema
- Distinct but heterogeneous clinical entity, most often affects current or former heavy smokers
IMAGING
General Features
Radiographic Findings
CT Findings
Imaging Recommendations
DIFFERENTIAL DIAGNOSIS
PATHOLOGY
General Features
Microscopic Features
CLINICAL ISSUES
Presentation
Demographics
Natural History & Prognosis
Treatment
Diagnosis
DIAGNOSTIC CHECKLIST
Image Interpretation Pearls
Reporting Tips
Selected References
- Hage R et al: Combined pulmonary fibrosis and emphysema (CPFE) clinical features and management. Int J Chron Obstruct Pulmon Dis. 16:167-77, 2021
- Bolaki M et al: Combined pulmonary fibrosis and emphysema. Semin Respir Crit Care Med. 41(2):177-83, 2020
- Amariei DE et al: Combined pulmonary fibrosis and emphysema: pulmonary function testing and a pathophysiology perspective. Medicina (Kaunas). 55(9), 2019
- Sousa C et al: Diffuse smoking-related lung diseases: insights from a radiologic-pathologic correlation. Insights Imaging. 10(1):73, 2019
- Hashimoto N et al: Impact of thin-section computed tomography-determined combined pulmonary fibrosis and emphysema on outcomes among patients with resected lung cancer. Ann Thorac Surg. 102(2):440-7, 2016
- Lin H et al: Combined pulmonary fibrosis and emphysema (CPFE): an entity different from emphysema or pulmonary fibrosis alone. J Thorac Dis. 7(4):767-79, 2015
- Choi SH et al: The value of CT for disease detection and prognosis determination in combined pulmonary fibrosis and emphysema (CPFE). PLoS One. 9(9):e107476, 2014
- Jankowich MD et al: Combined pulmonary fibrosis and emphysema syndrome: a review. Chest. 141(1):222-31, 2012
- Sakai F et al: Imaging diagnosis of interstitial pneumonia with emphysema (combined pulmonary fibrosis and emphysema). Pulm Med. 2012:816541, 2012
- Wright JL et al: Fibrosis with emphysema. Histopathology. 58(4):517-24, 2011
- Chung JH et al: Smoking-related interstitial lung diseases. Semin Roentgenol. 45(1):29-35, 2010
- Attili AK et al: Smoking-related interstitial lung disease: radiologic-clinical-pathologic correlation. Radiographics. 28(5):1383-96; discussion 1396-8, 2008
- Rao RN et al: Smoking-related interstitial lung disease. Ann Diagn Pathol. 12(6):445-57, 2008
- Wells AU et al: Challenges in pulmonary fibrosis. 4: smoking-induced diffuse interstitial lung diseases. Thorax. 62(10):904-10, 2007
- Hidalgo A et al: Smoking-related interstitial lung diseases: radiologic-pathologic correlation. Eur Radiol. 16(11):2463-70, 2006
- Remy-Jardin M et al: Lung parenchymal changes secondary to cigarette smoking: pathologic-CT correlations. Radiology. 186(3):643-51, 1993
